Patents by Inventor Daniel L. Klayman

Daniel L. Klayman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkaloids of picralima nitida used for treatment of protozoal diseases
    Patent number: 5290553
    Abstract: A method of preparing substantially purified alkaloids from seeds, stems, uit-rind and bark of a plant selected from Picralima nitida, Gongronema latifolia, Dorstenia multiradiata, Cola attiensis, Rothmania withfieldii and Desmodium gangeticum, for use in the treatment of protozoal diseases, comprising:pulverizing said plant;a first solvent, drying the extracted material and re-extracting the dried material with a different solvent;extracting a fresh sample of said plant with boiling water;filtering and concentrating the boiling water solvent extracts under reduced pressure;concentrating the dried extract to a gum and re-extracting said gum with an aqueous acidic HCl solution;filtering the acidic extract and making it alkaline to a pH of about 9 with a concentration NaOH solution;extracting the alkaline solution with dichloromethane;concentrating organic layers of the extracted alkaline solution to dryness under reduced pressure to obtain an alkaloid fraction; andseparating the alkaloid fraction by liquid chr
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: March 1, 1994
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Maurice M. Iwu, Daniel L. Klayman, Joan E. Jackson, John D. Tally, Steven L. Andersen
  • Heterocyclic and aromatic thiosemicarbazones useful in the treatment of filariasis
    Patent number: 5281597
    Abstract: This invention is directed to heterocyclic and aromatic thiosemicarbazones seful in the treatment of filariasis and in an animal, including humans.
    Type: Grant
    Filed: November 8, 1991
    Date of Patent: January 25, 1994
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John W. McCall, Daniel L. Klayman, Ai Jeng Lin, Kenneth E. Kinnamon, Max Grogl
  • Novel antimalarial dihydroartemisinin derivatives
    Patent number: 4791135
    Abstract: This invention relates to novel dihydroartemisinin derivatives, including their pharmaceutically-acceptable salts, which are therapeutically-effective in the pre- and post-treatment of malarial infections.
    Type: Grant
    Filed: August 20, 1987
    Date of Patent: December 13, 1988
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Ai J. Lin, Daniel L. Klayman, Wilbur K. Milhous
  • 2-acetyl-and 2-propionylpyridine thiosemicarbazones
    Patent number: 4739069
    Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
    Type: Grant
    Filed: December 7, 1984
    Date of Patent: April 19, 1988
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Daniel L. Klayman, John P. Scovill, Joseph F. Bartosevich, Carl J. Mason, T. Scott Griffin
  • 2-acetyl- and 2-propionylpyridine selenosemicarbazones
    Patent number: 4665173
    Abstract: This invention relates to novel 2-acetyl- and 2-propionylpyridine selenosemicarbazones. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the selenosemicarbazones.
    Type: Grant
    Filed: March 31, 1982
    Date of Patent: May 12, 1987
    Inventors: Daniel L. Klayman, John P. Scovill
  • Transition metal complexes of the selenium analogs of 2-acetyl- and 2-propionylpyridine thiosemicarbazones useful for treating malarial infections and leukemia
    Patent number: 4657903
    Abstract: This invention relates to novel transition metal complexes of 2-acetyl- and -propionylpyridine thiosemicarbazones, their selenium analogs. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones and their selenium analogs.
    Type: Grant
    Filed: March 31, 1982
    Date of Patent: April 14, 1987
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John P. Scovill, Daniel L. Klayman, Charles F. Franchino
  • 2-acetylpyridine thiosemicarbazones as antiviral agents
    Patent number: 4596798
    Abstract: This invention relates to the use of various 2-acetylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom in the treatment of viral infections. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
    Type: Grant
    Filed: March 30, 1982
    Date of Patent: June 24, 1986
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Charles Shipman, Jr., Daniel L. Klayman, Sandra H. Smith, John C. Drach
  • Medicinal 2-acetyl- and 2-propionylpyridine thiosemicarbazones and preparation thereof
    Patent number: 4493930
    Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
    Type: Grant
    Filed: October 14, 1981
    Date of Patent: January 15, 1985
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Daniel L. Klayman, John P. Scovill, Joseph F. Bartosevich, Carl J. Mason, T. Scott Griffin
  • Method for treating bacterial infections with 2-acetyl- and 2-propionylpyridine thiosemicarbazones
    Patent number: 4447427
    Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
    Type: Grant
    Filed: October 14, 1981
    Date of Patent: May 8, 1984
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Daniel L. Klayman, John P. Scovill, Joseph F. Bartosevich, Carl J. Mason, T. Scott Griffin
  • 2-Acetyl quinoline thiosemicarbazones useful in treatment of gonorrhea, malaria or bacterial infections
    Patent number: 4440771
    Abstract: This invention relates to the preparation and use of various 2-acetyl quiine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infections, such as leprosy and meningitis.
    Type: Grant
    Filed: February 12, 1982
    Date of Patent: April 3, 1984
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John P. Scovill, Daniel L. Klayman, Samuel P. Massie, Steven D. Grant, Armando Gonzalez, Norman E. Morrison, Arthur S. Dobek
  • Method for treating gonorrhea infections with 2-acetyl- and 2-propionylpyridine thiosemicarbazones
    Patent number: 4401670
    Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
    Type: Grant
    Filed: October 14, 1981
    Date of Patent: August 30, 1983
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Daniel L. Klayman, John P. Scovill, Joseph F. Bartosevich, Carl J. Mason, T. Scott Griffin
  • 2-Acetyl-and 2-propionylpyridine thiosemicarbazones as antimalarials
    Patent number: 4385055
    Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
    Type: Grant
    Filed: October 14, 1981
    Date of Patent: May 24, 1983
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Daniel L. Klayman, John P. Scovill, Joseph F. Bartosevich, Carl J. Mason, T. Scott Griffin
  • 2-Acetyl-and 2-propionylpyridine thiosemicarbazones
    Patent number: 4317776
    Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
    Type: Grant
    Filed: January 4, 1979
    Date of Patent: March 2, 1982
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Daniel L. Klayman, John P. Scovill, Joseph F. Bartosevich, Carl J. Mason, T. Scott Griffin