Patents by Inventor Daniel L. Lohse

Daniel L. Lohse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bi-aryl meta-pyrimidine inhibitors of kinases
    Patent number: 8604042
    Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: December 10, 2013
    Assignee: TargeGen, Inc.
    Inventors: Glenn Noronha, Chi Ching Mak, Jianguo Cao, Joel Renick, Andrew McPherson, Binqi Zeng, Ved P. Pathak, Daniel L. Lohse, John D. Hood, Richard M. Soll
  • BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES
    Publication number: 20110212077
    Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
    Type: Application
    Filed: August 24, 2010
    Publication date: September 1, 2011
    Applicant: TargeGen, Inc.
    Inventors: Glenn Noronha, Chi Ching Mak, Jianguo Cao, Joel Renick, Andrew McPherson, Binqi Zeng, Ved P. Pathak, Daniel L. Lohse, John D. Hood, Richard M. Soll
  • Bi-aryl meta-pyrimidine inhibitors of kinases
    Patent number: 7825246
    Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: November 2, 2010
    Assignee: TargeGen, Inc.
    Inventors: Glenn Noronha, Chi Ching Mak, Jianguo Cao, Joel Renick, Andrew McPherson, Binqi Zeng, Ved P. Pathak, Daniel L. Lohse, John D. Hood, Richard M. Soll
  • Bi-aryl meta-pyrimidine inhibitors of kinases
    Patent number: 7528143
    Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: May 5, 2009
    Assignee: TargeGen, Inc.
    Inventors: Glenn Noronha, Chi Ching Mak, Jianguo Cao, Joel Renick, Andrew McPherson, Binqi Zeng, Ved P. Pathak, Daniel L. Lohse, John D. Hood, Richard M. Soll
  • Purification, composition and specificity of heparinase I, II, and III from flavobacterium heparinum
    Patent number: 5569600
    Abstract: A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Monoclonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: October 29, 1996
    Assignees: Massachusetts Institute of Technology, University of Iowa Research Foundation
    Inventors: Ramnath Sasisekharan, Daniel L. Lohse, Charles L. Cooney, Robert J. Linhardt, Robert S. Langer
  • Purification of heparinase I, II, and III from Flavobacterium heparinum
    Patent number: 5389539
    Abstract: A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.
    Type: Grant
    Filed: November 30, 1992
    Date of Patent: February 14, 1995
    Assignees: Massachusetts Institute of Technology, University of Iowa Research Foundation
    Inventors: Ramnath Sasisekharan, Daniel L. Lohse, Charles L. Cooney, Robert J. Linhardt, Robert S. Langer
  • Purification of Heparinase I, II and III from Flavobacterium heparinum
    Patent number: RE41328
    Abstract: A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: May 11, 2010
    Assignees: Massachusetts Institute of Technology, University of Iowa Research Foundation
    Inventors: Ramnath Sasisekharan, Charles L. Cooney, Robert S. Langer, Daniel L. Lohse, Robert J. Linhardt
  • Purification, composition and specificity of Heparinase I, II, and III from Flavobacterium heparinum
    Patent number: RE41461
    Abstract: A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Mono-clonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: July 27, 2010
    Assignees: Massachusetts Institute of Technology, University of Iowa Research Foundation
    Inventors: Daniel L. Lohse, Robert J. Linhardt, Ramnath Sasisekharan, Charles L. Cooney, Robert S. Langer