Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5 and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5 and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

Abstract: The present embodiments provide compounds and methods for targeting cells expressing GLP-1 receptor.

Abstract: The present embodiments provide compounds and methods for targeting cells expressing GLP-1 receptor.

Abstract: The present embodiments provide compounds and methods for targeting cells expressing GLP-1 receptor.

Abstract: A fully electrically controlled electric braking system is provided for a road vehicle fitted with wheels (1). Each of the wheels is connected for rotation to at least one rotary electric machine (2) specific thereto, with at least one electronic wheel control module (23) controlling the electric machine(s) (2) of that wheel. Each electronic wheel control module (23) makes it possible to impart selectively to a corresponding wheel a control torque of determined amplitude and sign, in such a way that the corresponding wheel imparts to the vehicle a drive force or a braking force in accordance with the control torque. The system includes a central unit (3) for managing vehicle displacement, the central unit (3) controlling all the electronic wheel control modules (23). The central unit (3) has a vehicle braking mode activated by a vehicle braking control signal having a given amplitude representing a total desired braking force for the fully electrically controlled wheels.

Abstract: A fuel cell (FC) comprising a stack (A) of bipolar plates and ion exchange membranes arranged alternately, the stack (A) being clamped between two endplates (B and C), the stack (A) comprising feed and return ducts for the fluids required for the operation of the cell, said fluids comprising at least one fuel gas, the ducts communicating with a fluid management system comprising elements for controlling certain operating parameters, elements for recycling gases not consumed by the cell and elements for eliminating the water produced by the cell, said installation comprising connections for feeding gases to the cell, in which the fluid management system is at least partly integrated inside one of the endplates.

Abstract: A ground connection for a vehicle comprising a wheel (1), a sliding suspension for a wheel carrier relative to a support (10) connected to the vehicle, the suspension comprising a substantially vertical pillar (8) fixed to the wheel carrier, the degree of freedom of suspension of the wheel carrier relative to the support (10) being permitted by the movement of the pillar in the guide means (11) connected to the support, means for driving the wheel by a first rotary electric machine (15) mounted in the wheel, the first electric machine driving the wheel by means of reversible reduction means, the reduction means comprising a ring gear (16) fixed to the wheel and a drive pinion (17) connected to the first machine and defining a reduction ratio between the speed of rotation of the first machine and the speed of rotation of the wheel, the reduction ratio being greater than 10, said ground connection having no mechanical service brake.

Abstract: A ground contact system for a vehicle. The ground contact system comprises a wheel, a hub carrier, means for driving the wheel using at least one rotary motor secured to the hub carrier, reduction means comprising at least one gearwheel connected to the wheel and at least one pinion connected to the rotary motor, a sliding-bar suspension suspending the wheel from a support connected to the vehicle, and braking means. The braking means comprises a brake disc connected by its periphery to the wheel, and a brake calliper positioned inside the brake disc.

Abstract: A vehicle (1) equipped with a tank (2) for storage of a fluid under pressure on the vehicle, the tank being connected to at least one vent channel (3 and 33), the vent channel leading to a discharge orifice (34), the vent channel being connected to the tank by means of at least one safety valve, wherein in that the safety valve is a thermal release valve (5), normally closed and capable of opening spontaneously under the effect of a rise in temperature, the safety valve being installed in a predefined zone of the vehicle and the discharge orifice being remote from the predefined zone.

Abstract: A fuel cell (FC) comprising a stack (A) of bipolar plates and ion exchange membranes arranged alternately, the stack (A) being clamped between two endplates (B and C), the stack (A) comprising feed and return ducts for the fluids required for the operation of the cell, said fluids comprising at least one fuel gas, the ducts communicating with a fluid management system comprising elements for controlling certain operating parameters, elements for recycling gases not consumed by the cell and elements for eliminating the water produced by the cell, said installation comprising connections for feeding gases to the cell, in which the fluid management system is at least partly integrated inside one of the endplates.

Abstract: A vehicle (1) equipped with a tank (2) for storage of a fluid under pressure on the vehicle, the tank being connected to at least one vent channel (3 and 33), the vent channel leading to a discharge orifice (34), the vent channel being connected to the tank by means of at least one safety valve, wherein in that the safety valve is a thermal release valve (5), normally closed and capable of opening spontaneously under the effect of a rise in temperature, the safety valve being installed in a predefined zone of the vehicle and the discharge orifice being remote from the predefined zone.

Abstract: A method for treating the skin involves a first stage of softening the skin by projecting steam including treatment material on to it, causing the pores to open and the material to penetrate the outer skin surface. Thereafter the pores are caused to close e.g. by projecting an astringent composition on to the skin. Apparatus to effect this is described. One form includes a sealable chamber into which a quantity of liquid treatment preparation may be placed and heated to vaporise it and project the vapour via a nozzle (10) on to the skin surface, at a distance suitable for the treatment and established by a spacer (17) projecting from the side of a housing (1) containing the chamber and nozzle (10), and means (11) to trigger dispensing of the vapour when actuated.

Abstract: A ground connection for a vehicle comprising a wheel (1), a sliding suspension for a wheel carrier relative to a support (10) connected to the vehicle, the suspension comprising a substantially vertical pillar (8) fixed to the wheel carrier, the degree of freedom of suspension of the wheel carrier relative to the support (10) being permitted by the movement of the pillar in the guide means (11) connected to the support, means for driving the wheel by a first rotary electric machine (15) mounted in the wheel, the first electric machine driving the wheel by means of reversible reduction means, the reduction means comprising a ring gear (16) fixed to the wheel and a drive pinion (17) connected to the first machine and defining a reduction ratio between the speed of rotation of the first machine and the speed of rotation of the wheel, the reduction ratio being greater than 10, said ground connection having no mechanical service brake.

Abstract: A vehicle (1) equipped with a tank (2) for storage of a fluid under pressure on the vehicle, the tank being connected to at least one vent channel (3 and 33), the vent channel leading to a discharge orifice (34), the vent channel being connected to the tank by means of at least one safety valve, wherein in that the safety valve is a thermal release valve (5), normally closed and capable of opening spontaneously under the effect of a rise in temperature, the safety valve being installed in a predefined zone of the vehicle and the discharge orifice being remote from the predefined zone.

Abstract: A vehicle having a suspended body (1), at least two wheels (2) each mounted on a wheel support. Each wheel support is mounted on a suspension device (5) comprising a suspension support (4) and means for guiding the wheel support relative to the suspension support. The suspension device allows a vertical displacement of the wheel support relative to the suspension support, the size of the displacement being sufficient to produce the vertical suspension movement required. At least one wheel is arranged transversely on one side of the body and at least one other wheel is arranged on the other side of the body. Each suspension support is connected to the body by a height variation mechanism (3, 7, 11, 12) which allows the relative height of the suspension support relative to the body (1) to be varied. Each height variation mechanism is actuated by height control means (15, 16, 17, 18).

Abstract: A ground contact system for a vehicle. The ground contact system comprises a wheel, a hub carrier, means for driving the wheel using at least one rotary motor secured to the hub carrier, reduction means comprising at least one gearwheel connected to the wheel and at least one pinion connected to the rotary motor, a sliding-bar suspension suspending the wheel from a support connected to the vehicle, and braking means. The braking means comprises a brake disc connected by its periphery to the wheel, and a brake calliper positioned inside the brake disc.

Abstract: A vehicle (1) equipped with a tank (2) for storage of a fluid under pressure on the vehicle, the tank being connected to at least one vent channel (3 and 33), the vent channel leading to a discharge orifice (34), the vent channel being connected to the tank by means of at least one safety valve, wherein in that the safety valve is a thermal release valve (5), normally closed and capable of opening spontaneously under the effect of a rise in temperature, the safety valve being installed in a predefined zone of the vehicle and the discharge orifice being remote from the predefined zone.

Abstract: A vehicle (1) equipped with a tank (2) for storage of a fluid under pressure on the vehicle, the tank being connected to at least one vent channel (3 and 33), the vent channel leading to a discharge orifice (34), the vent channel being connected to the tank by means of at least one safety valve, wherein in that the safety valve is a thermal release valve (5), normally closed and capable of opening spontaneously under the effect of a rise in temperature, the safety valve being installed in a predefined zone of the vehicle and the discharge orifice being remote from the predefined zone.

Abstract: A vehicle has at least two driving wheels, each driven by an electric motor M via a gear change mechanism having at least two reduction gears. A sensor senses the rotation speed of the driving wheels. The gear change on the two driving wheels is carried out in an initial phase by: (a) releasing the current gear on a driving wheel referred to as the “operated” wheel, and stopping it in the neutral position, (b) changing the revolution speed of the motor so as to synchronize it as a function of the reduction of the gear to be engaged on the operated wheel, using as an estimate of the speed to-be-reached a speed information item obtained from another driving wheel, referred to as the “sensor” wheel, and (c) engaging the intended gear on the “operated” wheel. Then, in a successive phase, the gear on the other driving wheel is changed in the same manner by reversing the roles of the sensor wheel and the operated wheel.