Abstract: The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Abstract: The invention relates to pharmaceutical aerosols comprising the active compound cyclo(-Thr-Trp-Ile-Dab-Orn-DDab-Dab-Trp-Dab-Dab-Ala-Ser-DPro-Pro), or any pharmaceutically acceptable salt thereof. It further relates to liquid compositions comprising the active compound cyclo(-Thr-Trp-Il-Dab-Orn-DDab-Dab-Trp-Dab-Dab-Ala-Ser-DPro-Pro), dilutions thereof, kits comprising the liquid compositions, pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of diseases or conditions of the lungs such as cystic fibrosis (CF), non-cystic fibrosis bronchiectasis (NCFB), asthma, chronic obstructive pulmonary disease (COPD), ventilator-associated pneumonia (VAP), ventilator-associated bacterial pneumonia (VABP), hospital-acquired pneumonia (HAP), hospital-acquired bacterial pneumonia (HABP), or healthcare-associated pneumonia (HCAP).

Abstract: Electrolyte formulations for energy storage devices are disclosed. The energy storage device comprises a first electrode and a second electrode, where one or both of the first electrode and the second electrode is a Si-based electrode, a separator between the first electrode and the second electrode, and an electrolyte composition. Electrolyte formulations as described herein are electrolyte compositions comprising two or more components such as solvents, co-solvents, salts and/or additives. In some embodiments, three or more, four or more, five or more, six or more, seven or more, or eight or more components are included in the electrolyte composition.

Abstract: Systems, methods, and computer-readable storage media for locking-in currency exchanges. One method includes providing, by a graphical user interface (GUI) of a wallet application, a customer request, wherein the customer request is a request for a currency transfer between a customer account of the customer to a recipient account of a recipient, wherein the customer account is associated with a first type of currency and the recipient account is associated with a second type of currency, presenting, by the GUI of the wallet application, a locked-in exchange rate for a time limit and data corresponding to the exchange rate and the time limit, exchanging, by the wallet application, an amount of the first type of currency for an amount of the second type of currency based on the exchange rate, and receiving, by the GUI of the wallet application, an indication of a transferred amount for a currency transfer.

Abstract: Described herein are compounds, such as compounds represented by Formula I-R: and pharmaceutically acceptable salts, enantiomers, stereoisomers, and tautomers thereof, that are inhibitors of GCN2 kinase or PERK kinase, and methods of treating diseases, including diseases associated with GCN2 kinase or PERK kinase, with said compounds.

Abstract: A battery module includes a first side rail, a second side rail, one or more battery cell banks, and one or more battery cell separators. The one or more battery cell banks are positioned between the first side rail and the second side rail. The one or more battery cell separators are positioned within the one or more battery cell banks and configured to separate one or more battery cells positioned adjacent one another. The one or more battery cell separators include one or more cell barriers and a support structure. The one or more cell barriers are positioned adjacent the one or more battery cell banks. The support structure is positioned between the one or more cell barriers. The one or more battery cell separators are configured to propagate thermal energy produced from the one or more battery cells.

Abstract: Systems and methods for monitoring posture of a user wearing an exosuit are discussed herein. Exosuits worn by users can monitor several movement factors that characterize the user's movements and posture. The user's posture is identified and analyzed, and feedback is provided to the user based on the analyzed posture.

Abstract: A field of vehicles propelled by reaction, and more specifically to a method of suppressing the pogo effect in such a vehicle. A feed system for feeding a reaction engine of the vehicle includes a hydraulic accumulator enabling a selection to be made from among a plurality of predetermined operating levels, each corresponding to a different volume of gas. In the method, if a first reference criterion is not satisfied by the current level, the hydraulic accumulator is ordered to make a transition, preferably to an alternative level selected from among alternative levels for which the first reference criterion is satisfied and for which no hydraulic resonant frequency crosses any current mechanical resonant frequency during the transition.

Abstract: A device accesses a reference graphical item sequence. The reference graphical item sequence is known only to the first user. The device requests a user to point consecutively to at least one area in which at least one graphical item is included. The device presents a sequence of at least one graphical item. The device captures a sequence of at least one area pointed to by the user by detecting at least one predetermined change relating to at least one physical user feature to validate at least one user pointed area. The device verifies whether the sequence of the at least one user pointed area includes the reference graphical item sequence. The device authenticates the user only if the sequence of the at least one user pointed area includes the reference graphical item sequence.

Abstract: Systems and methods for monitoring posture of a user wearing an exosuit are discussed herein. Exosuits worn by users can monitor several movement factors that characterize the user's movements and posture. The user's posture is identified and analyzed, and feedback is provided to the user based on the analyzed posture.

Abstract: Systems and methods for detecting and analyzing lifting and bending motions performed by a user wearing an exosuit are discussed herein. Exosuits worn by users can monitor several movement factors that characterize the user's bending and lifting movements. The bend or lift is identified and analyzed, and feedback is provided to the user based on the analysis of the bend or lift.

Abstract: Systems and methods and media for managing biomechanical achievements are provided. An exosuit or any other suitable sensor assembly worn by a user can be utilized by a system to monitor several movement factors that may characterize the user's movement and any changes in the user's movement with a high degree of specificity that may enable various system algorithms and/or models to predict or otherwise determine one or more biomechanical achievements of the user, such as recovery from a particular type of event (e.g., surgery or therapy procedure) and/or distance traveled (e.g., without using any global positioning system capabilities). In addition, an exosuit can provide useful feedback in response to such determinations.

Abstract: Systems and methods and media for managing biomechanical achievements are provided. An exosuit or any other suitable sensor assembly worn by a user can be utilized by a system to monitor several movement factors that may characterize the user's movement and any changes in the user's movement with a high degree of specificity that may enable various system algorithms and/or models to predict or otherwise determine one or more biomechanical achievements of the user, such as recovery from a particular type of event (e.g., surgery or therapy procedure) and/or distance traveled (e.g., without using any global positioning system capabilities). In addition, an exosuit can provide useful feedback in response to such determinations.

Abstract: Exosuit systems and methods according to various embodiments are described herein. The exosuit can be used to monitor users for injury, perform injury prevention, and monitor works for productivity.

Abstract: A method of designing a valve presenting an orifice of section that depends on the position of the valve member of the valve, which section can thus be controlled. The method includes determining a desired variation relationship for the flow section of the valve, which relationship defines a desired variation in the section as a function of time; setting a predetermined movement relationship for the valve member; and defining the shape of the fluid flow orifice in such a manner that, at each instant, if the valve member moves in compliance with the predetermined movement relationship, the flow section remains equal to the desired section. The method makes it possible to design a valve that is simple to control.

Abstract: Techniques for providing file system functionality over a PCIe interface are disclosed. In some embodiments, the techniques may be realized as a method for providing file system functionality over a PCIe interface including receiving from a host device a storage command, specially devised for such a standard protocol, at a PCIe-based device controller, parsing, using at least one computer processor of the PCIe-based device controller, the storage command, traversing, using PCIe-based device controller, one or more portions of file system metadata of an associated storage media device, wherein the PCIe-based device controller is configured to traverse the one or more portions of file system metadata based on the parsed storage command independent of any subsequent communication with the host device, and returning data to the host device.

Abstract: A pressure regulator system (100) for regulating a pressure in a fluid line (16A) in such a manner that the pressure complies with a predetermined regulation criterion. The system comprises a valve (20A) that is controllable in on/off mode arranged at a downstream end of the line (16A) and suitable for oscillating between an open position and a closed position; a pressure sensor (40A) connected to the line (16A) and serving to measure the pressure in the line upstream from the valve (20A); and a regulator unit (50) configured to transmit to the valve (20A) open/close commands that are determined as a function of the measured pressure. A constant frequency imposes open periods (Oi) on the valve. The durations of the open periods are modulated in such a manner that the pressure in the line complies with said predetermined criterion.

Abstract: Systems, methods, and firmware for power control of data storage devices are provided herein. In one example, a data storage device is presented. The data storage device includes a storage control system to identify a power threshold for the data storage device. The data storage device determines power consumption characteristics for the data storage device and enters into a power controlled mode for the data storage device that adjusts at least a storage transaction queue depth in the data storage device to establish the power consumption characteristics as below the power threshold for the data storage device.

Abstract: Described herein are systems, methods, and software to manage metadata in a data storage device. In one example, a data storage device includes a first storage zone, a shingled magnetic recording (SMR) zone, and a storage control system. The storage control system is configured to maintain metadata in a metadata location of the first storage zone for user data in the SMR zone. The storage control system is further configured to, responsive to a usage condition being satisfied for the metadata in the metadata location, identify metadata locations in the SMR zone to redirect and store the metadata. The storage control system is also configured to maintain an indirection data structure in the metadata location of the first zone that correlates the metadata locations in the SMR zone to the metadata.

Abstract: A system and method for automatic location detection for wearable sensors can include collecting kinematic data from at least one kinematic activity sensor coupled to a user; generating a set of base kinematic metrics; assessing a set of sensor state discriminators and identifying a kinematic monitoring mode; and activating the kinematic monitoring mode at a kinematic activity sensor.