Patents by Inventor Daniel Lednicer
Daniel Lednicer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6498150Abstract: The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.Type: GrantFiled: October 7, 1999Date of Patent: December 24, 2002Assignee: Dovetail Technologies, Inc.Inventors: Floyd Taub, Thomas J. Perun, Christopher K. Murray, Randall J. Daughenbaugh, Daniel Lednicer
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Patent number: 6414114Abstract: The present invention is directed to novel disulfides and thiols that are of up to about eighteen amino acids. One example, is a compound of the formula (1): A—B—C—S—S—D—E—F, wherein: A and F are selected from the group consisting of hydrogen, an amino acid, a dipeptide, a tripeptide, a modified polypeptide up to three amino acids long, and a carbobenzoxy groups, B and E are selected from the group consisting of an amino acid, a dipeptide, a tripeptide, and a modified polypeptide comprising up to and including three amino acids, C and D are selected from the group consisting of a modified polypeptide and a polypeptide comprising up to and including three amino acids, and S is the sulfur atom in the modified polypeptide and the polypeptide in C and D.Type: GrantFiled: February 24, 1999Date of Patent: July 2, 2002Assignee: Dovetail Technologies, Inc.Inventors: Floyd E. Taub, Christopher K. Murray, Randall J. Daughenbaugh, Daniel Lednicer
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Publication number: 20020035118Abstract: The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.Type: ApplicationFiled: October 7, 1999Publication date: March 21, 2002Inventors: FLOYD TAUB, THOMAS J. PERUN, CHRISTOPHER K. MURRAY, RANDALL J. DAUGHENBAUGH, DANIEL LEDNICER
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Patent number: 6007819Abstract: The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.Type: GrantFiled: October 17, 1996Date of Patent: December 28, 1999Assignee: Dovetail Technologies, Inc.Inventors: Floyd Taub, Thomas J. Perun, Christopher K. Murray, Randall J. Daughenbaugh, Daniel Lednicer
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Patent number: 5126364Abstract: The compound (R) (-)-4-amino-5-chloro-N-(2-pyrrolidinylmethyl)-2,3-dihydrobenzo[b]furan-7-c arboxamide; the S isomer thereof, and pharmaceutical compositions containing the same.Type: GrantFiled: September 14, 1990Date of Patent: June 30, 1992Assignee: Erbamont, Inc.Inventors: Daniel Lednicer, Jung-Hui Sun
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Patent number: 4888353Abstract: Carboxamides represented by the formula (I): ##STR1## wherein Z represents the carbon atoms necessary to complete a 5- to 7-membered ring,R.sup.1, R.sup.2, and R.sup.3 may be the same or different and are selected from the group consisting of a hydrogen atom, a lower alkyl group, a cycloalkyl group, a halogen atom, an amino group, a lower alkylamino group, an alkoxy group, an acylamido group, a sulfonamido group, and a nitro group; andA represents an aminoalkyl moiety and acid addition salts thereof.Type: GrantFiled: May 23, 1986Date of Patent: December 19, 1989Assignee: Erbamont, Inc.Inventors: Daniel Lednicer, Jung-Hui Sun
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Patent number: 4471052Abstract: Chemically simplified versions of intermediates on the identified biosynthetic pathway to daunomycin are bioconverted to active analogues of naturally occurring antibiotics.Type: GrantFiled: January 18, 1982Date of Patent: September 11, 1984Assignee: Adria Laboratories, Inc.Inventors: Lester A. Mitscher, Daniel Lednicer
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Patent number: 4460604Abstract: A class of 4-amine-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts.Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.Type: GrantFiled: October 22, 1980Date of Patent: July 17, 1984Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4447454Abstract: Novel compounds of the formula: ##STR1## wherein R.sub.1 is a variable consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, CH.sub.2 -alkenyl wherein alkenyl is from 2 to 4 carbon atoms, inclusive, cycloalkyl of from 3 to 6 carbon atoms, inclusive, cycloalkylmethyl of from 3 to 6 carbon atoms, inclusive; R.sub.2 is a variable consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, inclusive, with the proviso that R.sub.1 and R.sub.2 cannot both be hydrogen at the same time; Y is a variable consisting of alkyl of from 1 to 4 carbon atoms, inclusive, halogen, trifluoromethyl, hydroxy, alkanoyloxy from 2 to 5 carbon atoms, inclusive, alkoxy of from 1 to 4 carbon atoms, inclusive, cycloalkyloxy of from 3 to 6 carbon atoms, inclusive, benzyloxy; m is an integer 0, 1, 2; R.sub.5 is a variable consisting of hydrogen and alkyl of from 1 to 4 carbon atoms, inclusive; R.sub.3 is a variable consisting of alkyl of from 1 to 4 carbon atoms, inclusive; R.sub.Type: GrantFiled: May 15, 1981Date of Patent: May 8, 1984Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4366172Abstract: Novel 4-aminocyclohexanols are formulated into pharmaceutical compositions for analgetic purposes in mammals in need of said treatment.Type: GrantFiled: September 29, 1977Date of Patent: December 28, 1982Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4346101Abstract: Benzamide derivative analgesic compounds of the formula ##STR1## wherein P, Q, R.sub.1, R.sub.2, X and Y are as defined in the specification, e.g., 3,4-Dichloro-N-[[8-(dimethylamino)-1,4-dioxaspiro[4.5]dec-8-yl]methyl]benz amide, and their pharmacologically acceptable salts, have analgesic drug properties with a low ratio of analgesic to sedative activity for use as analgesic drugs in mammalian animals, including humans.Type: GrantFiled: December 8, 1980Date of Patent: August 24, 1982Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4212878Abstract: N-[(1-Amino-4-(mono or di-oxygen-group-substituted)cyclohex-1-yl)methyl]phenylacetamide derivatives of the formula 1 ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, P, Q, X and Y are defined in the specification, e.g., 2-(3,4-dichlorophenyl)-N-[[8-(1-pyrrolidinyl)-1,4-dioxaspiro[4.5]dec.-8-yl ]methyl]acetamide, and their pharmacologically acceptable salts, have analgesic drug properties with lower physical dependence liability characteristics than morphine or methadone, for use as analgesic drugs in mammalian animals including humans.Type: GrantFiled: January 26, 1978Date of Patent: July 15, 1980Assignee: The Upjohn CompanyInventors: Daniel Lednicer, Jacob Szmuszkovicz
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Patent number: 4200588Abstract: Compounds of the formula ##STR1## where R.sub.4 X is a polycyclocoupled group and R.sub.1 and R.sub.2 are H or simple hydrocarbon and R.sub.3 has the same value and additionally simple acyl, can be made by a variety of syntheses. They have hypolipedemic and antiatherosclerotic properties, and are useful in that field.Type: GrantFiled: May 26, 1977Date of Patent: April 29, 1980Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4180584Abstract: A class of new 4-amino-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts.Processes for snythesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.Type: GrantFiled: October 11, 1977Date of Patent: December 25, 1979Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4143156Abstract: Novel 4-amino-cyclohexan-1-ols are formulated into pharmaceutical compositions for the relief of pain in mammals in need of said treatment.Type: GrantFiled: April 27, 1978Date of Patent: March 6, 1979Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4130561Abstract: Compounds of the formula ##STR1## where R.sub.4 X is a polycyclocoupled group and R.sub.1 and R.sub.2 are H or simple hydrocarbon and R.sub.3 has the same value and additionally simple acyl, can be made by a variety of syntheses. They have hypolipedemic and antiatherosclerotic properties, and are useful in that field.Type: GrantFiled: May 26, 1977Date of Patent: December 19, 1978Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4120899Abstract: Compounds of the formula ##STR1## where R.sub.4 X is a polycyclocoupled group and R.sub.1 and R.sub.2 are H or simple hydrocarbon and R.sub.3 has the same value and additionally simple acyl, can be made by a variety of syntheses. They have hypolipedemic and antiatherosclerotic properties, and are useful in that field.Type: GrantFiled: May 26, 1977Date of Patent: October 17, 1978Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4115589Abstract: 4-Amino-4-cyclohexan-1-ols are formulated into pharmaceutical compositions for the relief of pain in mammals in need of said treatment.Type: GrantFiled: May 17, 1977Date of Patent: September 19, 1978Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4113866Abstract: Novel compounds of the formula: ##STR1## wherein R.sub.1 is a variable consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, CH.sub.2 -alkenyl wherein alkenyl is from 2 to 4 carbon atoms, inclusive, cycloalkyl of from 3 to 6 carbon atoms, inclusive, cycloalkylmethyl of from 3 to 6 carbon atoms, inclusive; R.sub.2 is a variable consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, inclusive, with the proviso that R.sub.1 and R.sub.2 cannot both be hydrogen at the same time; Y is a variable consisting of alkyl of from 1 to 4 carbon atoms, inclusive, halogen, trifluoromethyl, hydroxy, alkanoyloxy from 2 to 5 carbon atoms, inclusive, alkoxy of from 1 to 4 carbon atoms, inclusive, cycloalkyloxy of from 3 to 6 carbon atoms, inclusive, benzyloxy; m is an integer 0, 1, 2; R.sub.5 is a variable consisting of hydrogen and alkyl of from 1 to 4 carbon atoms, inclusive; R.sub.3 is a variable consisting of alkyl of from 1 to 4 carbon atoms, inclusive; R.sub.Type: GrantFiled: April 1, 1977Date of Patent: September 12, 1978Assignee: The Upjohn CompanyInventor: Daniel Lednicer
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Patent number: 4065573Abstract: A class of new 4-amino-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts.Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.Type: GrantFiled: June 3, 1976Date of Patent: December 27, 1977Assignee: The Upjohn CompanyInventor: Daniel Lednicer