Abstract: Disclosed is a cross flow heat transfer apparatus for combined arrangement with an electronic display and integrated circuit chamber. The cross flow heat transfer apparatus comprising external heatsink configured to be arranged between electronic display and integrated circuit chamber, wherein external heatsink, with plurality of vertically-oriented fins, is configured to mediate cross flow heat transfer mechanism between electronic display and integrated circuit chamber. The cross flow heat transfer mechanism has internal flow driven by set of internal fans associated with internal heatsink coupled with integrated circuit chamber, wherein internal flow is directed transversally towards electronic display from the integrated circuit chamber, and external flow driven by plurality of vertically-oriented fins of external heatsink based on temperature gradient.

Abstract: The present invention relates to a chimeric target molecule having an activity which can be regulated or modulated by a binding molecule. The invention also relates to methods of using the chimeric target molecule to detect the presence and/or amount of a desired analyte in a sample. The analyte is a binding molecule, or a competitor of a binding molecule, which binding molecule, upon binding to the target molecule, alters the activity of the target molecule in a detectable way. In one aspect of the invention, a binding molecule binds to the chimeric molecule, inactivating it. An analyte in a test sample competes and/or displaces the binding molecule from the chimera, reactivating it. The reappearance of activity in the presence of the analyte indicates its existence in the test sample existence and amount. Another aspect of the invention relates to a binding molecule which regulates a chimeric target molecule and methods of producing it.