Patents by Inventor Daniel Lesieur

Daniel Lesieur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5147883
    Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 represents a hydrogen atom or a lower alkyl group,A represents a hydrogen atom, and in this case B represents a group CO-G, G being:either a heteroaryl group selected from furan, indole, pyrrole, pyridine, quinoline, isoquinoline and benzofuran, optionally substituted with one or more lower alkyl or lower alkoxy groups or a halogen atoms,or a linear or branched lower alkyl group substituted with a carboxyl group,or a linear or branched lower alkenyl group substituted with a carboxyl group,or a phenyl or naphthyl group substituted with a carboxyl group,or alternatively A forms with B a group CO(CH.sub.2).sub.n CH(CH.sub.
    Type: Grant
    Filed: May 31, 1991
    Date of Patent: September 15, 1992
    Assignee: Adir et Compagnie
    Inventors: Hocine Aichaioui, Daniel Lesieur, Charles Lespagnol, Michelle Devissaguet, Beatrice Guardiola
  • Patent number: 5132305
    Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 denotes a hydrogen atom or a lower alkyl optionally substituted with a hydroxyl group,R.sub.2 and R.sub.3 :a--identical or different, denote a hydrogen atom, a lower alkyl, a lower alkenyl, a substituted or unsubstituted aryl, a substituted or unsubstituted (lower alkyl)aryl,b--are such that they form, with the nitrogen which carries them, a saturated or unsaturated, mono- or bicyclic heterocyclic system containing at most 3 hetero atoms per ring, substituted or unsubstituted, with the exception of 1-arylpiperazine systems,X denotes a hydrogen atom,Y denotes a hydrogen atom or a hydroxyl,or alternatively X and Y denote an oxygen atom, provided that R.sub.1 is then other than a methyl group,Z denotes a hydrogen atom or forms a .pi. bond with Y, andT denotes a hydrogen atom or a lower alkyl, their stereoisomers and their quaternary ammonium salts, as well as their addition salts with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: July 21, 1992
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Charles Lespagnol, Jacqueline Bonnet
  • Patent number: 4960778
    Abstract: Compounds of the general formula (I): ##STR1## in which: X denotes a hydrogen atom,Y denotes a hydrogen atom or a hydroxyl group or alternatively X and Y together denote an oxygen atom,T denotes a hydrogen atom or a lower alkyl group,Z denotes a hydrogen atom or alternatively Z forms a .pi. bond with Y, in which case X denotes a hydrogen atom,R denotes a hydrogen atom or a lower alkyl group,Ar denotes an aryl or heteroaryl or (lower alkyl)aryl group, such as pyrimidinyl, optionally substituted with a halogen atom, or a lower alkyloxy or alkyl group, themselves optionally substituted with one or more halogen atoms,their enantiomers, epimers and diastereoisomers, as well as their addition salts with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: October 3, 1989
    Date of Patent: October 2, 1990
    Assignee: ADIR Et Cie
    Inventors: Daniel Lesieur, Nourddine Abdellatifi, Hocine Aichaoui, Jacqueline Bonnet
  • Patent number: 4558060
    Abstract: The invention relates to compounds of the formula: ##STR1## in which R represents hydrogen or a lower alkyl radical and R.sub.1 and R.sub.2 separately represent hydrogen, a lower alkyl, cycloalkyl or benzyl radical, or represent, together with the nitrogen atom to which they are bonded, a heterocyclic radical such as a morpholino, 4-(pyrimidin-2-yl)-piperazinyl or 4-phenylpiperazinyl the phenyl radical of which being optionally substituted by halogen, lower alkoxy or trifluoromethyl, having CNS activity and particularly hypnotic properties.Moreover the compounds in which R.sub.1 and R.sub.2 are hydrogen can be used in the treatment of heart failure.
    Type: Grant
    Filed: November 22, 1983
    Date of Patent: December 10, 1985
    Assignee: Riom Laboratories - Cerm S.A.
    Inventors: Daniel H. Caignard, Charles Lespagnol, Daniel Lesieur, Norbert Busch