Patents by Inventor Daniel Levin

Daniel Levin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200205875
    Abstract: An ablation system includes multiple electrodes configured to contact body tissue of a patient, including two or more ablation electrodes for contacting respective locations in a target organ and a return electrode. A signal-generating unit includes multiple signal generators, which are configured to apply respective composite signals to respective ones of the ablation electrodes. The composite signals include multiple, respective signal components, including respective ablation signals, having different, respective ablation-signal amplitudes and phases at a common ablation-signal frequency, and respective probe signals having respective probe-signal amplitudes and different respective probe-signal frequencies. A processor is coupled to measure the probe signals received by each of the multiple electrodes, and responsively to the measured probe signals, to control the ablation-signal amplitudes and phases.
    Type: Application
    Filed: November 4, 2019
    Publication date: July 2, 2020
    Inventors: Michael Levin, Daniel Osadchy, Eyal Rotman, Yavgeny Bonyak, Boris Ashkinezer, Alek Vilensky
  • Patent number: 10696680
    Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: June 30, 2020
    Assignee: NeOnc Technologies, Inc.
    Inventors: Thomas Chen, Daniel Levin, Satish Puppali
  • Publication number: 20200172557
    Abstract: Au(III) complexes for [18F] trifluoromethylation and methods for producing the same are disclosed. A gold complex comprises Au(CF3)2LR, wherein L comprises a solubility supporting ligand and R comprises an organic substituent. The Au(III) complex can be used to prepare a positron emitting isotope that can be used as tracers for positron emitting tomography (PET) scans.
    Type: Application
    Filed: May 21, 2018
    Publication date: June 4, 2020
    Inventors: F. Dean Toste, Mark Daniel Levin, James Patrick O'Neil
  • Publication number: 20200170961
    Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
    Type: Application
    Filed: November 6, 2019
    Publication date: June 4, 2020
    Inventors: Thomas Chen, Daniel Levin, Satish Pupalli, Daniel Anthony Dickman
  • Publication number: 20200165603
    Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
    Type: Application
    Filed: May 22, 2019
    Publication date: May 28, 2020
    Inventors: Kamila Belhocine, Rajiv Bharadwaj, Christopher Hindson, Michael Schnall-Levin, Bill Kengli Lin, Anthony Makarewicz, Pranav Patel, Katherine Pfeiffer, Andrew D. Price, Mohammad Rahimi Lenji, Tobias Daniel Wheeler, Yifeng Yin
  • Patent number: 10662209
    Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: May 26, 2020
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
  • Publication number: 20200131106
    Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.
    Type: Application
    Filed: September 19, 2019
    Publication date: April 30, 2020
    Inventors: Thomas CHEN, Daniel LEVIN, Satish PUPALLI
  • Publication number: 20200078355
    Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
    Type: Application
    Filed: April 15, 2019
    Publication date: March 12, 2020
    Inventors: Thomas CHEN, Daniel LEVIN, Satish PUPALLI
  • Publication number: 20200078462
    Abstract: The present invention provides for a perillyl alcohol (POH) carbamate, such as POH-Rolipram. The present invention also provides for a method of treating a disease such as cancer, by delivering to a patient a therapeutically effective amount of POH-Rolipram.
    Type: Application
    Filed: April 18, 2019
    Publication date: March 12, 2020
    Inventors: Thomas CHEN, Daniel Levin, Satish Pupalli
  • Patent number: 10570105
    Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (XI): wherein Y is C1-C12 alkylene or C1-C12 alkenylene; and R8 and R12 are independently C1-C12 alkyl.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: February 25, 2020
    Assignee: Firmenich Incorporated
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin
  • Publication number: 20200039150
    Abstract: A method of printing a three-dimensional (3D) object and a support construction for the 3D object includes depositing a model material, layer-by-layer, on a fabrication platform, to print a first portion of the 3D object, and depositing a support material, layer-by-layer on the fabrication platform, to print the support construction, wherein, in a predetermined number of the deposited layers, the model material and the support material are deposited such that a gap is formed between a surface of the first portion of the 3D object and a surface of the support construction.
    Type: Application
    Filed: August 20, 2019
    Publication date: February 6, 2020
    Applicant: STRATASYS LTD.
    Inventors: Daniel DIKOVSKY, Eduardo NAPADENSKY, Shai HIRSCH, Evgeni LEVIN, Yoav BRESSLER
  • Publication number: 20200024596
    Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
    Type: Application
    Filed: May 22, 2019
    Publication date: January 23, 2020
    Inventors: Kamila Belhocine, Rajiv Bharadwaj, Christopher Hindson, Michael Schnall-Levin, Bill Kengli Lin, Anthony Makarewicz, Pranav Patel, Katherine Pfeiffer, Andrew D. Price, Mohammad Rahimi Lenji, Tobias Daniel Wheeler, Yifeng Yin
  • Publication number: 20190383798
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and antigen screening. Polynucleotide processing may be useful for a variety of applications. Antigen screening may comprise the use of one or more engineered cells. Engineered cells may be useful for characterizing one or more analytes including, for example, a polypeptide antigen.
    Type: Application
    Filed: April 4, 2019
    Publication date: December 19, 2019
    Inventors: Kamila Belhocine, Jason Bell, Zachary Bent, Rajiv Bharadwaj, Christopher Hindson, Mohammad Rahimi Lenji, Bill Kengli Lin, Anthony Makarewicz, Geoffrey McDermott, Elliott Meer, Francesca Meschi, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Michael Schnall-Levin, Sarah Taylor, Jessica Michele Terry, Tobias Daniel Wheeler, Yifeng Yin, Xinying Zheng, Solongo Batjargal Ziraldo, Eswar Prasad Ramachandran Iyer, Luigi Jhon Alvarado Martinez
  • Publication number: 20190383804
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, epigenetic information (e.g., accessible chromatin, DNA methylation), and RNA molecules (e.g., mRNA or CRISPR guide RNAs). In some cases, the disclosed methods comprise analysis of analytes from a cell using a cell bead.
    Type: Application
    Filed: April 4, 2019
    Publication date: December 19, 2019
    Inventors: Kamila Belhocine, Jason Bell, Zachary Bent, Rajiv Bharadwaj, Christopher Hindson, Mohammad Rahimi Lenji, Bill Kengli Lin, Anthony Makarewicz, Geoffrey McDermott, Elliott Meer, Francesca Meschi, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Michael Schnall-Levin, Sarah Taylor, Jessica Michele Terry, Tobias Daniel Wheeler, Yifeng Yin, Xinying Zheng, Solongo Batjargal Ziraldo, Eswar Prasad Ramachandran Iyer, Luigi Jhon Alvarado Martinez
  • Publication number: 20190367969
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins) and chromatin (e.g., accessible chromatin).
    Type: Application
    Filed: April 4, 2019
    Publication date: December 5, 2019
    Inventors: Kamila Belhocine, Jason Bell, Zachary Bent, Rajiv Bharadwaj, Christopher Hindson, Mohammad Rahimi Lenji, Bill Kengli Lin, Anthony Makarewicz, Geoffrey McDermott, Elliott Meer, Francesca Meschi, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Michael Schnall-Levin, Sarah Taylor, Jessica Michele Terry, Tobias Daniel Wheeler, Yifeng Yin, Xinying Zheng, Solongo Batjargal Ziraldo, Eswar Prasad Ramachandran Iyer, Luigi Jhon Alvarado Martinez
  • Publication number: 20190367982
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications, including cell lineage analysis. Cell lineage analysis may comprise the use of one or more lineage tracing nucleic acid molecules. The disclosed methods may comprise using a lineage tracing nucleic acid molecule to identify a biological particle with one or more progenitor cells.
    Type: Application
    Filed: April 4, 2019
    Publication date: December 5, 2019
    Inventors: Kamila Belhocine, Jason Bell, Zachary Bent, Rajiv Bharadwaj, Christopher Hindson, Mohammad Rahimi Lenji, Bill Kengli Lin, Anthony Makarewicz, Geoffrey McDermott, Elliot Meer, Francesca Meschi, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Michael Schnall-Levin, Sarah Taylor, Jessica Michele Tery, Tobias Daniel Wheeler, Yifeng Yin, Xinying Zheng, Solongo Batjargal Ziraldo, Eswar Prasad Ramachandran Iyer, Luigi Jhon Alvarado Martinez
  • Publication number: 20190367966
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from one or more cells. Such polynucleotide processing may be useful for a variety of applications, including characterization of major histocompatibility complex (MHC) molecules. The compositions, methods, systems, and devices disclosed herein generally describe peptides and barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing MHC molecules from one or more cells.
    Type: Application
    Filed: April 4, 2019
    Publication date: December 5, 2019
    Inventors: Kamila Belhocine, Jason Bell, Zachary Bent, Rajiv Bharadwaj, Christopher Hindson, Mohammad Rahimi Lenji, Bill Kengli Lin, Anthony Makarewicz, Geoffrey McDermott, Elliott Meer, Francesca Meschi, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Michael Schnall-Levin, Sarah Taylor, Jessica Michele Terry, Tobias Daniel Wheeler, Yifeng Yin, Xinying Zheng, Solongo Batjargal Ziraldo, Eswar Prasad Ramachandran Iyer, Luigi Jhon Alvarado Martinez
  • Publication number: 20190361010
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from one or more cells. Such polynucleotide processing may be useful for a variety of applications, including generation of labeled macromolecules, including major mistocompatability complex (MHC) molecules, dextramers, etc. Labeled macromolecules may be generated using an in vitro transcription reaction. Labeled macromolecules may be generated in one or more partitions.
    Type: Application
    Filed: April 4, 2019
    Publication date: November 28, 2019
    Inventors: Kamila Belhocine, Jason Bell, Zachary Bent, Rajiv Bharadwaj, Christopher Hindson, Mohammad Rahimi Lenji, Bill Kengli Lin, Anthony Makarewicz, Geoffrey McDermott, Elliott Meer, Francesca Meschi, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Michael Schnall-Levin, Sarah Taylor, Jessica Michele Terry, Tobias Daniel Wheeler, Yifeng Yin, Xinying Zheng, Solongo Batjargal Ziraldo, Eswar Prasad Ramachandran Iyer, Luigi Jhon Alvarado Martinez
  • Patent number: 10457618
    Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: October 29, 2019
    Assignee: NeOnc Technologies, Inc.
    Inventors: Thomas Chen, Daniel Levin, Satish Puppali
  • Patent number: 10428326
    Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: October 1, 2019
    Assignee: 10X GENOMICS, INC.
    Inventors: Kamila Belhocine, Rajiv Bharadwaj, Christopher Hindson, Michael Schnall-Levin, Bill Lin, Anthony Makarewicz, Pranav Patel, Katherine Pfeiffer, Andrew D. Price, Mohammad Rahimi Lenji, Tobias Daniel Wheeler, Yifeng Yin