Abstract: The disclosure is directed to novel solid-state forms of Compound 9 and pharmaceutically acceptable salts of Compound 9, compositions comprising the same, and methods of using the same, including use in treating cancer, hypoxia related pathologies, disorders leading to ischemia, and non-cancerous angiogenic diseases.

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-? which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-? which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Abstract: A distributed control system and method for decentralized, collaborative platform navigation, routing, and/or control are disclosed employing a distributed, factorized positioning, navigation, and timing chain that can link platforms or nodes having local sensors together by their local inertial and ranging measurements. In the distributed, factorized PNT chain, each platform maintains and contributes local measurements as states to a set of dynamically assigned parent node for a platform cluster, each parent nodes and associated clusters links to at least one other parent node aggregates the states of the platforms in the cluster and passes/propagates states of a linked clustered.

Abstract: Systems and methods for automated cutting of lumber are disclosed. The system includes a loading module that receives lumber from a loading area and places the lumber on a cutting table. The system includes an actuating module that receives the lumber from the loading module, inspects the lumber, records lumber information based on the inspection, and positions the lumber on the cutting table in preparation for cutting. The system includes a sensor module that detects the position of the lumber on the cutting table, and records the position to the lumber information. The system includes a computing module that analyzes the lumber information received from the actuating module and sensor module. The system includes a cutting module that cuts the lumber based the lumber information, the cutting resulting in cut lumber. The system includes an unloading module that places the cut lumber on an unloading area.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: Systems and methods for a stud plate connector are disclosed. The system can include a base plate having a first cam slot and a second cam slot, where the second cam slot is approximately a mirror image of the first cam slot. The system can include a first upper cam-follower located within the first cam slot. The system can include a second upper cam-follower located within the second cam slot, where the first and second cam-followers hold opposite sides of a first lumber and move the first lumber to contact a second lumber. The system can include a first lower gripper and a second lower gripper for holding the second lumber in a perpendicular direction with respect to the first lumber. The system can include a bonding device located before to the first and second lumber, where the bonding device bonds the first and second lumber together.

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-? which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Abstract: The present invention relates to salts and crystalline forms of 2-(3-(8-Amino-6-(trifluoromethyl)imidazo[1,2-a]pyrazin-3-yl)-4-methylphenyl)-3,3,3-trifluoro-2-hydroxypropanamide, crystalline forms of 8-amino-N-(2-hydroxy-2-methylpropyl)-3-(2-methyl-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide, and crystalline forms of 8-amino-N-(2-hydroxy-2-methylpropyl)-3-(2-(methyl-d3)-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide, which are PI3K inhibitors useful in the treatment of cancer and other diseases.

Abstract: A portable sled for transporting cargo in outdoor environments comprises overlapping High-Density Polyethylene (HDPE) sheets arranged in a fish-scale configuration. The design features a structural aluminum body with eye bolts at the front and nylon straps for securing cargo. The sled's fish-scale assembly reduces drag, optimizes weight distribution, and minimizes snagging. Heat-treated HDPE sheets 101 maintain a curved shape when assembled but flatten for storage. The sled incorporates high-visibility colors for safety and is buoyant for water-based operations. Its modular design allows for easy assembly and disassembly in the field, making it highly portable and versatile for various outdoor scenarios.

Abstract: A correction optical element (COE) for a multi-channeled coherent beam combining (CBC) system that uses a fiber array comprising multiple optical fibers and a single collimation array comprising multiple collimating lenses, for coherent combining of a corresponding array of optical beams directed through the fiber array. The COE is configured for customized and segmented correction of collimation-based optical aberrations, caused at least due to misalignments between each corresponding optical fiber's Lij output end and a center of a corresponding collimating lens Lij.

Abstract: Systems, methods and subsystems for adjustment of optical path length (OPL) of optical beams of a multi-channel optical system, by using an OPL adjustment subsystem that includes an array of OPL adjustors, each configured and located to controllably adjust OPL of an optical beam of a corresponding optical channel. For each optical beam of each optical channel one or more updated properties associated with the optical beam is detected to determine, based on detected data analysis, required one or more updated adjustor-control properties, for achieving an associated desired OPL adjustment of the corresponding optical beam. Each OPL adjustor is controlled to adjust the OPL of its corresponding optical beam, according to the determined one or more updated adjustor-control properties. The detection, analysis and/or OPL adjustment may be performed in a parallel manner to all optical channels of the multi-channel optical system.

Abstract: A system and method for bi-directional design to code are disclosed. In one embodiment, the system includes a processor; a memory storing instructions that, when executed, cause the system to obtain, by a plugin, a web application design, the web application design generated using a first design tool; generate, by the plugin, an object model based on the web application design; access, by a configurator, the object model; and generate, by the configurator, for presentation to a developer, the web application design.

Abstract: A modification setup including an array of modification units, each positioned and configured to: cause light of an input optical beam to pass through a corresponding input surface of the respective modification unit, in a manner that reduces exceeding of its light, from a first effective aperture of the input surface; and modify beam profile of the input optical beam, to form an intermediate optical beam having a beam profile of illumination distribution factor that is higher than that of the input optical beam. An output surface of the modification unit, located at a distance D from the input surface is configured and positioned such that the intermediate optical beam passes through the output surface at increased illumination cover area and decreased exceeding from a second effective aperture of the output surface. Each input beam may be collimated before entering the input surface of a corresponding modification unit.

Abstract: The present invention relates to salts and crystalline forms of 2-(3-(8-Amino-6-(trifluoromethyl)imidazo[1,2-a]pyrazin-3-yl)-4-methylphenyl)-3,3,3-trifluoro-2-hydroxypropanamide, crystalline forms of 8-amino-N-(2-hydroxy-2-methylpropyl)-3-(2-methyl-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide, and crystalline forms of 8-amino-N-(2-hydroxy-2-methylpropyl)-3-(2-(methyl-d3)-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide, which are PI3K inhibitors useful in the treatment of cancer and other diseases.

Abstract: Aspects of embodiments pertain to systems and methods for beam combining, using at least a first set of coherent beam combining (CBC) devices, each being configured to combine coherent optical beams directed thereto and to output a coherent combined output optical beam and at least one additional combining device, configured to combine multiple optical beams. Combined output optical beams, outputted by each CBC device of the first set of CBC devices, are directed towards an input surface of the at least one additional combining device, which combines the directed combined output optical beams, outputted by the first set of CBC devices, by the at least one additional combining device, outputting a single combined final output optical beam and directing thereof externally from the at least one additional combining device.

Abstract: Systems and methods for automated cutting of lumber are disclosed. The system includes a loading module that receives lumber from a loading area and places the lumber on a cutting table. The system includes an actuating module that receives the lumber from the loading module, inspects the lumber, records lumber information based on the inspection, and positions the lumber on the cutting table in preparation for cutting. The system includes a sensor module that detects the position of the lumber on the cutting table, and records the position to the lumber information. The system includes a computing module that analyzes the lumber information received from the actuating module and sensor module. The system includes a cutting module that cuts the lumber based the lumber information, the cutting resulting in cut lumber. The system includes an unloading module that places the cut lumber on an unloading area.

Abstract: Systems and methods for automated cutting of lumber are disclosed. The system includes a loading module that receives lumber from a loading area and places the lumber on a cutting table. The system includes an actuating module that receives the lumber from the loading module, inspects the lumber, records lumber information based on the inspection, and positions the lumber on the cutting table in preparation for cutting. The system includes a sensor module that detects the position of the lumber on the cutting table, and records the position to the lumber information. The system includes a computing module that analyzes the lumber information received from the actuating module and sensor module. The system includes a cutting module that cuts the lumber based the lumber information, the cutting resulting in cut lumber. The system includes an unloading module that places the cut lumber on an unloading area.

Abstract: Systems and methods for a stud plate connector are disclosed. The system can include a base plate having a first cam slot and a second cam slot, where the second cam slot is approximately a mirror image of the first cam slot. The system can include a first upper cam-follower located within the first cam slot. The system can include a second upper cam-follower located within the second cam slot, where the first and second cam-followers hold opposite sides of a first lumber and move the first lumber to contact a second lumber. The system can include a first lower gripper and a second lower gripper for holding the second lumber in a perpendicular direction with respect to the first lumber.

Abstract: A distributed control system and method for decentralized, collaborative platform navigation, routing, and/or control are disclosed employing a distributed, factorized positioning, navigation, and timing chain that can link platforms or nodes having local sensors together by their local inertial and ranging measurements. In the distributed, factorized PNT chain, each platform maintains and contributes local measurements as states to a set of dynamically assigned parent node for a platform cluster, each parent nodes and associated clusters links to at least one other parent node aggregates the states of the platforms in the cluster and passes/propagates states of a linked clustered.