Patents by Inventor Daniel LEY

Daniel LEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for reducing ammonium and lactate production in CHO cells
    Patent number: 10961556
    Abstract: The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: March 30, 2021
    Assignee: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Daniel Ley, Mikael Rørdam Andersen, Helene Faustrup Kildegaard
  • METHOD FOR REDUCING AMMONIUM AND LACTATE PRODUCTION IN CHO CELLS
    Publication number: 20190203249
    Abstract: The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.
    Type: Application
    Filed: August 15, 2017
    Publication date: July 4, 2019
    Inventors: Daniel LEY, Mikael Rørdam ANDERSEN, Helene Faustrup KILDEGAARD