Abstract: The present disclosure provides methods of treating cancer in a subject including administering a therapeutic composition comprising an ATR inhibitor and a hypomethylating agent. Methods of inducing DNA replication stress or cell death in a cancer cell are also provided. The combination of an ATR inhibitor and hypomethylating agent is particularly useful for treating TP53-mutated cancers, such as acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

Abstract: The invention relates to a window comprising a window frame and a casement which can be displaced in relation to the window frame, mountings which are arranged between the casement and the window frame and which are used to displace the casement in relation to the window frame, and a handle which is disposed on the casement. The handle comprises control elements and/or sensors and a handle part which can be displaced, particularly rotated, on the casement in various positions of the handle which correspond to different operational positions of the casement. The handle is connected in a wireless manner or via electric lines to electromagnetic or electromechanical locking elements between the casement and the window frame, and/or to electromagnetic or electromechanical functions, in particular coupling elements for at least one or several mountings and/or to an electromechanical drive device which is used to open or close the casement.

Abstract: An apparatus for mounting a flipchip onto a work piece comprises a pick-up station for presentation of the flipchip, a transport mechanism, at least one pick-up tool arranged on the transport mechanism for pick-up and transport of the flipchip from the pick-up station to the work piece and a position acquisitioning device arranged on the transport mechanism for determining the position of the picked up flipchip. The position acquisitioning device comprises a slide and a single line camera secured to the slide, a guide element for guiding the slide, a drive mechanism for driving the slide and a measuring device for determining the position of the slide.

Abstract: An apparatus for mounting a flipchip onto a work piece comprises a pick-up station for presentation of the flipchip, a transport mechanism, at least one pick-up tool arranged on the transport mechanism for pick-up and transport of the flipchip from the pick-up station to the work piece and a position acquisitioning device arranged on the transport mechanism for determining the position of the picked up flipchip. The position acquisitioning device comprises a slide and a single line camera secured to the slide, a guide element for guiding the slide, a drive mechanism for driving the slide and a measuring device for determining the position of the slide.