Patents by Inventor Daniel Little

Daniel Little has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the synthesis of soritin compounds
    Patent number: 7074938
    Abstract: Disclosed herein are methods for synthesizing biologically active bis-heterocyclic compounds, e.g. bis-indoles. In particular, methods for making Soritin compounds such as Soritin B, bis-(1H-indol-3-yl)-acetic acid methyl ester, Soritin C, bis-2,2-(1-methyl-indol-3-yl) acetic acid methyl ester, Soritin D, bis-2,2-(1-methyl-indol-3-yl) acetic acid and Soritin compositions comprising the Soritin compounds are disclosed. Also disclosed are pharmaceutical formulations comprising the Soritin compounds and Soritin compositions.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: July 11, 2006
    Assignee: The Regents of the University of California
    Inventors: Robert S. Jacobs, R. Daniel Little
  • Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
    Publication number: 20060051879
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
    Type: Application
    Filed: January 16, 2004
    Publication date: March 9, 2006
    Inventors: Hubert Koster, Daniel Little, Suhaib Siddiqi, Matthew Grealish, Subramanian Marappan, Chester Hassman, Ping Yip
  • Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
    Publication number: 20050042771
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
    Type: Application
    Filed: January 16, 2004
    Publication date: February 24, 2005
    Inventors: Hubert Koster, Daniel Little, Suhaib Siddiqi, Matthew Grealish, Subramanian Marappan, Chester Hassman, Ping Yip
  • Method for the synthesis of Soritin compounds
    Publication number: 20040147585
    Abstract: Disclosed herein are methods for synthesizing biologically active bis-heterocyclic compounds, e.g bis-indoles. In particular, methods for making Soritin compounds such as Soritin B, bis-(1H-indol-3-yl)-acetic acid methyl ester, Soritin C, bis-2,2-(1-methyl-indol-3-yl) acetic acid methyl ester, Soritin D, bis-2,2-(1-methyl-indol-3-yl) acetic acid and Soritin compositions comprising the Soritin compounds are disclosed. Also disclosed are pharmaceutical formulations comprising the Soritin compounds and Soritin compositions.
    Type: Application
    Filed: November 18, 2003
    Publication date: July 29, 2004
    Inventors: Robert S. Jacobs, R. Daniel Little
  • Mass spectrometric detection of polypeptides
    Publication number: 20030003465
    Abstract: A process for ascertain sequence information about a nucleic acid molecule by determining the identity of a polypeptide using mass spectroscopy is provided. Depending on the polypeptide to be identified, a process as disclosed is used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity. Kits for performing the disclosed processes also are provided.
    Type: Application
    Filed: November 6, 2001
    Publication date: January 2, 2003
    Inventors: Daniel Little, Hubert Koster, G. Scott Higgins, David Lough
  • Mass spectrometric detection of polypeptides
    Patent number: 6387628
    Abstract: A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity. Kits for performing the disclosed processes also are provided.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: May 14, 2002
    Assignee: Sequenom, Inc.
    Inventors: Daniel Little, Hubert Köster, G. Scott Higgins, David Lough
  • Mass spectrometric detection of polypeptides
    Patent number: 6322970
    Abstract: A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity. Kits for performing the disclosed processes also are provided.
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: November 27, 2001
    Assignee: Sequenom, Inc.
    Inventors: Daniel Little, Hubert Köster, G. Scott Higgins, David Lough