Abstract: There is provided polymeric nanoparticles with non-tumour antigen payloads for use in tagging cells for destruction by a subject's immune system and the use thereof for the treatment of cancer. Suitably there is provided a method of treatment comprising administration of nanoparticle comprising a non-tumour protein payload to a subject with cancer, in particular to a cancer cell.

Abstract: This disclosure relates to an enhanced molecular-targeted approach that targets treatment-induced or native hypoxia present within cancers, specifically, but not limited to the treatment of metastatic prostate cancer with androgen deprivation therapy, such as anti-androgens. The disclosure describes the utility of combined inhibition of IL-8 and VEGF signalling to effect a combined therapeutic response of malignant disease, which is magnified under conditions of hypoxia. Thus, provided is a pharmaceutical combination for use in the treatment of cancer, the pharmaceutical combination comprising: a vascular endothelial growth factor (VEGF) signalling inhibitor; and an interleukin-8 (IL-8) signalling inhibitor; wherein said use comprises administration of the pharmaceutical combination to a patient receiving an anti-cancer therapy.

Abstract: Methods, systems, and computer-readable media for implementing interaction reconstruction in a service-oriented system are disclosed. Routes are stored for a first set of service interactions between individual services in a service-oriented system. The routes comprise data indicative of call paths for node identifiers in the first set of service interactions. A sparse trace is generated for a second set of service interactions between individual ones of the services. The sparse trace comprises a plurality of node identifiers in the second set of service interactions. Based on the node identifiers in the sparse trace and the node identifiers in the plurality of routes, the sparse trace is matched to one or more of the routes.

Abstract: The invention relates to methods and compositions for treatment of cancer. In one embodiment the method involves the use of a c-FLIP inhibitor as the sole active agent. In another embodiment the invention relates to the treatment of p53 mutant cancers using combinations of c-FLIP inhibitors and chemotherapeutic agents.

Abstract: The invention provides combination therapies and methods for the treatment of cancers associates with p53 mutations. The method comprises the separate, sequential or simultaneous administration of a therapeutically effective amount of a) a specific binding member, for example CH-11, which binds to a cell death receptor, for example Fas, or a nucleic acid encoding said binding member and b) a chemotherapeutic agent, wherein the chemotherapeutic agent is a topoisomerase inhibitor, for example CPT-1 or a thymidylate synthase inhibitor, for example TDX. Synergistic cytotoxic effects have been demonstrated using such combinations.

Abstract: Described is a method to predict response of tumour cells to in vivo treatment with a platinum-based chemotherapeutic agent, the method based on the determination of the expression of one or more of the genes encoding BCRP protein, wherein enhanced expression of said gene correlates with enhanced resistance to the chemotherapeutic agent. Also described are methods of sensitising cancer cells, particularly colorectal cancer cells to treatment.

Abstract: Techniques for eliminating duplicate/redundant scanning of email messages while the email message traverses the various servers within an email infrastructure are provided. Some techniques utilize a message hygiene stamp that is transported with the email message as the email message enters an enterprise and is routed within the enterprise until the email message reaches the end user inbox. The filters comprise logic that enables the filters to annotate the result of their filtering or other processing in corresponding message hygiene stamps. The message hygiene stamps allow the filters to determine whether the email message has already been processed by the filter within the email infrastructure.

Abstract: Within a mail transfer agent of a message transfer system, a message is received and if the recipient entity resolves to a number of recipients exceeding a specified quantity, the original message is not processed. Instead, at least two messages are created, with each of the created messages addressed to a subset of the original set of recipients. The created messages are returned to the calling module for processing.

Abstract: Within a mail transfer agent of a message transfer system, a message is received and if the recipient entity resolves to a number of recipients exceeding a specified quantity, the original message is not processed. Instead, at least two messages are created, with each of the created messages addressed to a subset of the original set of recipients. The created messages are returned to the calling module for processing.

Abstract: Within a mail transfer agent of a message transfer system, a message is received and if the recipient entity resolves to a number of recipients exceeding a specified quantity, the original message is not processed. Instead, at least two messages are created, with each of the created messages addressed to a subset of the original set of recipients. The created messages are returned to the calling module for processing.

Abstract: The present invention provides a method of killing cancer cells and method of treatment of cancer comprising administration of a therapeutically effective amount of a) a specific binding member which binds to a cell death receptor or a nucleic acid encoding said binding member and (b) a chemotherapeutic agent. The binding member pereferably binds to a Fas receptor. Also described are medicaments for use in treating cancer.

Abstract: The present invention extends to methods, systems, and computer program products for e-mail envelope journaling. A server determines that an entity's (e.g., a recipient revealed form an expanded distribution list) home mailbox store has envelope journaling enabled and specifies a journaling mailbox address. The server sets a journaling property in an e-mail message identifying that the e-mail message is to be journaled. The server adds the journaling mailbox address specified by the entity's home mailbox store to the journaling property. The server sends envelope journaling information through an envelope protocol extension to the journaling mailbox addresses specified in the journaling property. The server sends the e-mail message to one or more recipients specified in the e-mail message and journaling mailbox addresses specified in the journaling property.

Abstract: The present invention extends to methods, systems, and computer program products for e-mail envelope journaling. A server determines that an entity's (e.g., a recipient revealed form an expanded distribution list) home mailbox store has envelope journaling enabled and specifies a journaling mailbox address. The server sets a journaling property in an e-mail message identifying that the e-mail message is to be journaled. The server adds the journaling mailbox address specified by the entity's home mailbox store to the journaling property. The server sends envelope journaling information through an envelope protocol extension to the journaling mailbox addresses specified in the journaling property. The server sends the e-mail message to one or more recipients specified in the e-mail message and journaling mailbox addresses specified in the journaling property.