Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

Abstract: A viscosity measurement system and method of fabrication thereof, the system comprising a measuring element and a housing, the measuring element comprising a base and a counterweight, forced oscillation generating means, a tube, and a rod; the base, the counterweight and the forced oscillation means being sealed in the housing; the tube extending out of the housing through an opening in a bottom wall of the housing; the forced oscillation generating means being connected to an electric board secured to a top wall of the housing opposite the bottom wall for excitation of the rod; and the rod extending within the tube and immerging of the housing for immersion, at least in part, in a fluid to be measured, wherein the counterweight is distant from the top wall and from lateral walls of the housing, and the base is supported by the bottom wall of the housing in such a way to simultaneously provide a rigid attachment on an outer circumference of the bottom wall and on a circumference of the opening in the bottom w

Abstract: A device is suitable for revealing spatial variations in polarization of an electromagnetic radiation, in a form of localized temperature variations. The device includes a surface of a carrier which is electrically and thermally insulating, and includes an array of patterns which each consist of at least one rectilinear segment of a sensitive material, of which the orientation is variable within each pattern or between neighboring patterns. Such device may be used with a thermal camera to reveal, in infrared images, temperature variations which are localized at segments not perpendicular to a local direction of linear polarization of the radiation.

Abstract: Methods for treating symptomatic obstructive hypertrophic cardiomyopathy (oHCM) are described herein. The treatment methods include the administration of a cardiac myosin inhibitor (CK-3773274, also referred to as CK-274 or aficamten) and may include titrating an administrated daily dose based on one or more components of an echocardiogram. The daily dose may be increased, maintained, decreased, or terminated, based on the echocardiogram. The methods may be useful for treating patients who have been recently diagnosed with oHCM, patients who are treatment naïve for oHCM, or patients who have previously received SOC medical therapy for oHCM and have discontinued said therapy prior to administration of aficamten, such as patients with chronic oHCM.

Abstract: A method for providing energy from waste heat from an electrolysis process to one or more commercial or industrial operations is provided. The method includes the steps of converting water to oxygen and a hydrogen product through an electrolysis process, wherein the hydrogen product has a carbon intensity less than about 0.45 kg CO2e/kg H2, and wherein at least some of the required energy for the electrolysis process is provided from a biomass power plant. The method further includes recovering waste heat from the electrolysis process, and then converting at least some of the waste heat to thermal energy for use in the one or more commercial or industrial operations. Examples of commercial and industrial operations includes, without limitation, greenhouses, algae farms, district cooling, and district heating.

Abstract: Pulse-generator-based reciprocal quantum logic (RQL) bias-level sensors are fabricated on an RQL integrated circuit (IC) to sample AC or DC bias values provided to operational RQL circuitry on the RQL IC. The bias-level sensors include pulse generators having strengthened or weakened bias taps (transformer couplings to RQL AC clock resonators or DC bias lines) as compared to bias taps of Josephson transmission lines in the operational RQL circuitry, or Josephson junctions (JJs) with larger or smaller critical currents as compared to JJs in the operational RQL circuitry. Pulse generators with weakened bias taps or larger JJs can have lower limits of their operational ranges placed near an optimal bias point at the centroid of the operating region of the operational RQL circuitry. The bias-level sensors can be staged by relative strength to indicate whether a provided bias value is an improvement when varied over a range.

Abstract: Methods for treating non-obstructive hypertrophic cardiomyopathy or hypertrophic cardiomyopathy with mid-ventricular obstruction (MVO) are described herein. The treatment methods include the administration of a cardiac myosin inhibitor (CK-3773274, also referred to as CK-274 or aficamten) and may include titrating an administrated daily dose based on a component of an echocardiogram. The daily dose may be increased, maintained, or decreased, or terminated, based on the echocardiogram.

Abstract: Some headphone systems include two ear cups, a headband assembly, an interface system and a control system. Each ear cup may include an ear cup enclosure, an ear pad assembly, a speaker system and a hinge assembly. The hinge assembly may be disposed within the ear cup enclosure such that it is not visible from outside the ear cup. The headband assembly may connect with each of the ear cups via the hinge assembly. The interface system may include at least one interface and a plurality of input source buttons disposed on at least one of the ear cups. Each of the input source buttons may be configured for selecting a source of audio data received via the at least one interface. The control system may be configured for controlling the speaker system to reproduce audio data received via the interface and selected by one of the input source buttons.

Abstract: The disclosed technology relates to a lubricating composition comprising an oil of lubricating viscosity and an ashless basic amine additive selected from a secondary amine containing ?-carbon aromatic substitution. The basic secondary amine additives used in the lubricating oils of the disclosed technology impart basicity measured as total base number (TBN) without adding sulfated ash. Lubricating oils containing the basic secondary amine additives of the disclosed technology simultaneously achieve seals compatibility, deposit, and corrosion control.

Abstract: A drill bit has a plurality of cutters secured to the bit body, including a gauge cutter defining a gauge diameter of the drill bit. A reciprocating gauge assembly on the bit comprises a cavity defined in the bit body, a piston reciprocably disposed in the cavity, a wear element on an outwardly facing end of the piston, a piston retainer for moveably retaining the piston in the cavity, and a spring biasing the piston outwardly to a neutral position of the wear element with respect to the gauge diameter. The wear element and piston may be urged inwardly in response to an applied load at the drill bit gauge pad, increasing the lateral depth of cut and thereby controlling the aggressiveness of the bit in response to the load.

Abstract: Configurable filters for asymmetrical radio frequency communication are disclosed. In one aspect, a radio frequency module includes a first filter configured to band-pass frequencies for a first transmit sub-band of a first communication band, a second filter configured to band-pass frequencies for a second transmit sub-band of the first communication band, and a third filter configured to band-pass frequencies for a receive band of the first communication band. The radio frequency module further includes an antenna terminal and at least one antenna switch module configured to connect the third filter and one of the first and second filters to the antenna terminal.

Abstract: A computer-implemented technique is described herein for assisting a user in advancing a task objective. The technique uses a suggestion-generating system (SGS) to provide one or more suggestions to a user in response to at least a last-submitted query provided by the user. The SGS may correspond to a classification-type or generative-type neural network. The SGS uses a machine-trained model that is trained using a multi-task training framework based on plural groups of training examples, which, in turn, are produced using different respective example-generating methods. One such example-generating method constructs a training example from queries in a search session. It operates by identifying the task-related intent the queries, and then identifying at least one sequence of queries in the search session that exhibits a coherent task-related intent. A training example is constructed based on queries in such a sequence.

Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

Abstract: Configurable filter bands for radio frequency communication are disclosed. In one aspect, a radio frequency module includes a plurality of n-plexers, each of the n-plexers including n filters, each of the filters configured to pass at least one radio frequency band, and at least two of the radio frequency bands having overlapping frequencies, an antenna terminal, and an antenna switch module configured to connect two or more of the n-plexers to the antenna terminal.

Abstract: A system for forensic file services is configured to receive data indicative of operations executed on a filesystem element stored on a computing resource associated with a first tenant, to and adjust the data according to an indicated database schema. The system is also configured to store the adjusted data in a record of a partition of a database, where the partition configured to store a history of operations executed on filesystem elements of computing resources associated with the first tenant. The system is further configured to receive a search request to search the database and to execute the search request on a second partition of the database to identify one or more matching records. The system is additionally configured to provide the identified records in response to the search request.

Abstract: Many conventional advertisements designed for display as part of a web page executed by a web browser are not suitable for display in an online video player that, though included in a web page, is executed by a multimedia platform. Such conventional advertisements are referred to herein as web page advertisements. A system display a web page advertisement in the frame of such an online video player by determining characteristics of the video player in the context of the multimedia platform and converting those characteristics into a context compatible with the web browser. The system can also include a virtual web browser that executes either on the multimedia platform on a server device that is communicatively coupled to the multimedia platform. The system can also include an ad tag translator that executes either on the multimedia platform on a server device that is communicatively coupled to the multimedia platform.

Abstract: A filter unit includes a body portion that receives a water filter. An engaging portion is coupled to the body portion. A bypass actuator rotates relative to the engaging portion to rotationally and axially operate a bypass valve of a fluid manifold. The bypass actuator drives axial engagement of the engaging portion with a valve assembly of the fluid manifold. The bypass actuator extends through the body portion and the engaging portion.

Abstract: This application is directed to a surveillance camera system including a magnet mount for physically receiving a camera module. The camera module includes a housing having an exterior surface of a first shape. A surface of the magnet mount has a second shape that is substantially concave and complementary to the first shape, and is configured to engage the exterior surface of the housing of the camera module. A magnetic material is disposed inside the magnet mount and configured to magnetically couple to a magnetic material of the camera module. A friction pad is embedded on the surface of the magnet mount, has a substantially concave shape and protrudes beyond the second surface. The friction pad is configured to come into contact with the exterior surface of the housing of the camera module at least via a peripheral edge of the substantially concave friction pad.

Abstract: A system for forensic file services is configured to receive data indicative of operations executed on a filesystem element stored on a computing resource associated with a first tenant, to and adjust the data according to an indicated database schema. The system is also configured to store the adjusted data in a record of a partition of a database, where the partition configured to store a history of operations executed on filesystem elements of computing resources associated with the first tenant. The system is further configured to receive a search request to search the database and to execute the search request on a second partition of the database to identify one or more matching records. The system is additionally configured to provide the identified records in response to the search request.

Abstract: Many conventional advertisements designed for display as part of a web page executed by a web browser are not suitable for display in an online video player that, though included in a web page, is executed by a multimedia platform. Such conventional advertisements are referred to herein as web page advertisements. A system display a web page advertisement in the frame of such an online video player by determining characteristics of the video player in the context of the multimedia platform and converting those characteristics into a context compatible with the web browser. The system can also include a virtual web browser that executes either on the multimedia platform on a server device that is communicatively coupled to the multimedia platform. The system can also include an ad tag translator that executes either on the multimedia platform on a server device that is communicatively coupled to the multimedia platform.