Abstract: An ablation system comprises: an ablation catheter and a console. The ablation catheter comprises: a shaft including a proximal end, a distal portion and a distal end; an ablation element configured to deliver energy to tissue; and a force maintenance assembly comprising a force maintenance element and configured to control and/or assess contact force between the ablation element and cardiac tissue. The console is configured to operably attach to the ablation catheter and comprises: an energy delivery assembly configured to provide energy to the ablation element. Methods of ablating tissue are also provided.

Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.

Abstract: A developer material cartridge including a robust multiple function seal, for use in a developer unit of an electrostatographic reproduction machine including a machine interface member. The developer material cartridge includes a cylindrical housing defining a developer material containing chamber and an open end into the chamber. The robust multiple function seal comprises a single member including a solid first end for sealing the open end into the developer material containing chamber during shipping and transportation of the cartridge. The single member also includes a partially slit-through second end and lead in recess for enabling non-damaging coupling with, as well as puncturing of the solid first end by, the machine interface member, thereby avoiding the undesirable risks of seal damage and developer material spills.