Abstract: A charged depth filter for removing cells and/or cellular debris from a biopharma feedstock having a first functionalized nonwoven layer having a first calculated pore size and a first dynamic charge capacity; a second functionalized nonwoven layer having a second calculated pore size and a second dynamic charge capacity positioned after the first functionalized nonwoven layer in the direction of the biopharma feedstock flow, and wherein the first calculated pore size is greater than the second calculated pore size, and the first dynamic charge capacity is less than the second dynamic charge capacity.

Abstract: A wheel brake for shopping carts and other wheeled equipment is disclosed. Typically, shopping carts and other wheeled equipment have a yoke depending from a lower end of a leg support, the yoke including a pair of generally parallel downwardly extending arms. A wheel is rotatably mounted on an axle extending between these downwardly extending arms. In order to provide selective braking engagement of the wheel to immobilize the shopping cart or other wheeled equipment, a brake tongue is pivotally mounted at one end to the yoke above the wheel and extends across at least a part of the wheel. A foot pedal is pivotally mounted to the yoke in spaced relationship to the brake tongue for movement between engaged and released positions relative to the wheel. The foot pedal includes a depending brake element for engaging and depressing the brake tongue into selective braking engagement with the wheel when the foot pedal is moved into engaged position by a user.