Patents by Inventor Daniel M. Pinkas
Daniel M. Pinkas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8470782Abstract: Transglutaminase inhibitors and methods of use thereof are provided.Type: GrantFiled: August 28, 2006Date of Patent: June 25, 2013Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
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Publication number: 20130116412Abstract: Bacterial cells capable of producing recombinant proteins, such as post-translationally hydroxylated recombinant proteins, methods and kits for producing recombinant proteins, such as post-translationally hydroxylated recombinant proteins, and particular post-translationally hydroxylated recombinant collagen molecules produced by the methods and cells disclosed herein are provided by this invention.Type: ApplicationFiled: April 1, 2011Publication date: May 9, 2013Inventors: Daniel M. Pinkas, Sheng Ding, Annelise E. Barron
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Patent number: 7758814Abstract: A microfluidic fluid distribution manifold includes a common port and a plurality of fluidic channels spirally wound around the common port. Each fluidic channel connects the common port to an independent port and provides essentially the same flow resistance to a fluid flowing therethrough. A fixture for the flow restrictor allows fluid flows to be communicated between the flow restrictor and a larger system such as a parallel reactor system.Type: GrantFiled: June 3, 2005Date of Patent: July 20, 2010Assignee: Freeslate, Inc.Inventors: Daniel M. Pinkas, H. Sam Bergh, Shenheng Guan, Nallakkan Arvindan
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Publication number: 20090312272Abstract: Transglutaminase inhibitors and methods of use thereof are provided.Type: ApplicationFiled: August 4, 2009Publication date: December 17, 2009Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
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Patent number: 7579313Abstract: Transglutaminase inhibitors and methods of use thereof are provided.Type: GrantFiled: August 26, 2005Date of Patent: August 25, 2009Assignees: The Board of Trustees of the Leland Stanford Junior University, The Washington UniversityInventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
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Publication number: 20090042806Abstract: Transglutaminase inhibitors and methods of use thereof are provided.Type: ApplicationFiled: August 28, 2006Publication date: February 12, 2009Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
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Patent number: 7281408Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.Type: GrantFiled: November 20, 2003Date of Patent: October 16, 2007Assignee: Symyx Technologies, Inc.Inventors: Ravi Srinivasan, Daniel M. Pinkas, Shenheng Guan, Michael Myslovaty, Mikhail Spitkovsy, James R. Engstrom, H. Sam Bergh
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Patent number: 7254990Abstract: A sensor for sensing one or more properties of a vehicle fluid has a tuning fork resonator adapted to contact the fluid. The tuning fork resonator comprises two tines and is operable to oscillate so that the two tines move in opposite phase at a frequency of less than 1 MHz while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. In another aspect, a sensor includes a substrate and a flexural resonator on the substrate and adapted to contact the fluid. Circuitry for operation of the resonator is on the substrate. The resonator is adapted to receive an input signal and to oscillate while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. One suitable application for the invention is monitoring the condition of a vehicle engine oil.Type: GrantFiled: May 12, 2006Date of Patent: August 14, 2007Assignee: Visyx Technologies, Inc.Inventors: Leonid Matsiev, James Bennett, Daniel M. Pinkas, Mikhail Spitkovsky, Oleg Kolosov, Shenheng Guan, Mark Uhrich, G. Cameron Dales, John F. Varni, Blake Walker, Vladimir Gammer, Dave Padowitz, Eric Low
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Patent number: 7134459Abstract: Method for preparing a mixed powder sample by mixing two or more different powders comprising transferring a quantity of a first powder to a mixing vessel and transferring a quantity of a second powder to the mixing vessel to form a powder bed in the mixing vessel comprising the first and second powders. The quantities of the powders are selected so the mixed sample has a predetermined ratio of first powder to second powder. The powder bed is fluidized to mix the powders and produce a mixed sample. The mixed sample weighs about 5 grams or less. The invention also includes apparatus for preparing mixed powder samples by mixing two or more different powders.Type: GrantFiled: June 3, 2004Date of Patent: November 14, 2006Assignee: Symyx Technologies, Inc.Inventors: Eric Carlson, Li Song, Daniel M. Pinkas, Claus G. Lugmair
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Patent number: 7043969Abstract: A method for analyzing a fluid contained within a machine, comprising the steps of providing a machine including a passage for containing a fluid; placing a sensor including a mechanical resonator in the passage; operating the resonator to have a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. A preferred sensor includes a tuning fork resonator.Type: GrantFiled: June 2, 2003Date of Patent: May 16, 2006Assignee: Symyx Technologies, Inc.Inventors: Leonid Matsiev, James Bennett, Daniel M. Pinkas, Mikhail Spitkovsky, Oleg Kolosov, Shenheng Guan, Mark Uhrich, G. Cameron Dales, John F. Varni, Blake Walker, Vladimir Gammer, Dave Padowitz, Eric Low
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Publication number: 20040261897Abstract: Method for preparing a mixed powder sample by mixing two or more different powders comprising transferring a quantity of a first powder to a mixing vessel and transferring a quantity of a second powder to the mixing vessel to form a powder bed in the mixing vessel comprising the first and second powders. The quantities of the powders are selected so the mixed sample has a predetermined ratio of first powder to second powder. The powder bed is fluidized to mix the powders and produce a mixed sample. The mixed sample weighs about 5 grams or less. The invention also includes apparatus for preparing mixed powder samples by mixing two or more different powders.Type: ApplicationFiled: June 3, 2004Publication date: December 30, 2004Applicant: Symyx Technologies, Inc.Inventors: Eric Carlson, Li Song, Daniel M. Pinkas, Claus G. Lugmair
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Patent number: 6805175Abstract: Apparatus for aspirating and dispensing powder, comprising a hopper having a powder transfer port and a suction port for connection to a source of suction to establish an upward flow of air (or other gas) through the transfer port. A gas flow control system varies the upward flow through the transfer port to have different velocities greater than 0.0 m/s. These velocities include an aspirating velocity for aspirating powder into the hopper through the transfer port to form a fluidized bed of powder in the hopper, and a dispensing velocity less than the aspirating velocity but sufficient to maintain fluidization of the bed while allowing powder from the bed to gravitate through the transfer port for dispensing into one or more destination receptacles. A method of aspirating and dispensing powder is also disclosed.Type: GrantFiled: June 12, 2003Date of Patent: October 19, 2004Assignee: Symyx Technologies, Inc.Inventors: Daniel M. Pinkas, Claus G. Lugmair
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Patent number: 6742544Abstract: A novel gas injection valve for injecting discrete charges of gas into a mobile phase or carrier stream is provided. Injection valves of the invention comprise a plurality of microvalves capable of receiving gas at different pressures and emitting discrete charges of gas at approximately the same pressure. The invention further provides for parallel injection valve arrays capable of injecting multiple samples substantially simultaneously and a method of injecting discrete gas samples at a controlled pressure to a high-resolution gas chromatograph.Type: GrantFiled: March 6, 2002Date of Patent: June 1, 2004Assignee: Symyx Technologies, Inc.Inventors: H. Sam Bergh, Daniel M. Pinkas, Frank Doffing, Michael Klaus, Friedhelm Schoenfeld
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Publication number: 20040099050Abstract: A method for analyzing a fluid contained within a machine, comprising the steps of providing a machine including a passage for containing a fluid; placing a sensor including a mechanical resonator in the passage; operating the resonator to have a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. A preferred sensor includes a tuning fork resonator.Type: ApplicationFiled: June 2, 2003Publication date: May 27, 2004Applicant: Symyx Technologies, Inc.Inventors: Leonid Matsiev, James Bennett, Daniel M. Pinkas, Mikhail Spitkovsky, Oleg Kolosov
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Publication number: 20030032198Abstract: This invention provides an apparatus and method for dispensing fluidic materials involving the employment of a hydrophilic capillary dimensioned for drawing a liquid therein in a volume less than about 10 microliters; a hydrophobic medium sealingly adjoining said capillary and defining an interface therewith for resisting flow of the liquid into the capillary beyond the interface; and a source of a pressure pulse for ejecting fluids drawn into the capillary.Type: ApplicationFiled: August 13, 2001Publication date: February 13, 2003Applicant: Symyx Technologies, Inc.Inventors: Claus G. Lugmair, Daniel M. Pinkas
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Publication number: 20020124897Abstract: A novel gas injection valve for injecting discrete charges of gas into a mobile phase or carrier stream is provided. Injection valves of the invention comprise a plurality of microvalves capable of receiving gas at different pressures and emitting discrete charges of gas at approximately the same pressure. The invention further provides for parallel injection valve arrays capable of injecting multiple samples substantially simultaneously and a method of injecting discrete gas samples at a controlled pressure to a high-resolution gas chromatograph.Type: ApplicationFiled: March 6, 2002Publication date: September 12, 2002Applicant: Symyx Technologies, Inc.Inventors: H. Sam Bergh, Daniel M. Pinkas
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Publication number: 20020127146Abstract: A novel gas injection valve for injecting discrete charges of gas into a mobile phase or carrier stream is provided. Injection valves of the invention comprise a plurality of microvalves capable of receiving gas at different pressures and emitting discrete charges of gas at approximately the same pressure. The invention further provides for parallel injection valve arrays capable of injecting multiple samples substantially simultaneously and a method of injecting discrete gas samples at a controlled pressure to a high-resolution gas chromatograph.Type: ApplicationFiled: March 6, 2002Publication date: September 12, 2002Applicant: Symyx Technologies, Inc.Inventors: H. Sam Bergh, Daniel M. Pinkas
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Publication number: 20020042140Abstract: Protocols for designing and implementing sets of simultaneous experiments, in a parallel, multi-variable process optimization reactor, are disclosed. The multi-variable process optimization reactor is preferably a parallel flow reactor having the operational capability to simultaneously vary reaction conditions between reaction vessels—either modularly or independently. The simultaneously varied reaction conditions preferably include at least two of the following, in various combinations and permutations: space velocity, contact time, temperature, pressure and feed composition. Compositional variations in the catalysts residing in each of the reaction vessels can also be investigated in the set of simultaneous experiments implemented in the parallel reactor. Sufficient data is obtained from a single set of simultaneous experiments to generate a master curve.Type: ApplicationFiled: July 9, 2001Publication date: April 11, 2002Inventors: Alfred Hagemeyer, Anthony F. Volpe, Claus Lugmair, David M. Lowe, Yumin Liu, H. Sam Bergh, Shenheng Guan, Daniel M. Pinkas, Kyle W. Self, James R. Engstrom, Laurent Lefort