Patents by Inventor Daniel M. Ratner
Daniel M. Ratner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11105820Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: GrantFiled: September 11, 2020Date of Patent: August 31, 2021Assignees: University of Washington through its Center for Commercialization, BloodworksInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Publication number: 20210088535Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: ApplicationFiled: September 28, 2020Publication date: March 25, 2021Applicants: University of Washington through its Center for Commercialization, BloodworksInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Publication number: 20200408785Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: ApplicationFiled: September 11, 2020Publication date: December 31, 2020Applicants: University of Washington through its Center for Commercialization, BloodworksInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Patent number: 10794921Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: GrantFiled: July 27, 2018Date of Patent: October 6, 2020Assignees: University of Washington, Puget Sound Blood CenterInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Patent number: 10709791Abstract: Polymeric carriers for the delivery of therapeutic agents and methods for making and using the same. The polymeric carriers include copolymers, diblock copolymers, polymeric architectures that include the copolymers and diblock copolymers, and particles assemblies comprising the copolymers, diblock copolymers, and polymeric architectures that include the copolymers.Type: GrantFiled: November 12, 2015Date of Patent: July 14, 2020Assignee: University of WashingtonInventors: Patrick S. Stayton, Anthony J. Convertine, Daniel M. Ratner, Debobrato Das, Selvi Srinivasan
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Publication number: 20190365906Abstract: Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.Type: ApplicationFiled: April 11, 2019Publication date: December 5, 2019Applicant: University of Washington through its Center for CommercializationInventors: Patrick S. Stayton, Anthony Convertine, Daniel M. Ratner, Selvi Srinivasan, Debobrato Das, Fang-Yi Su, Jasmin Chen, David Yee-Shawn Chiu, Daniel Douglas Lane
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Publication number: 20190041410Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: ApplicationFiled: July 27, 2018Publication date: February 7, 2019Applicants: University of Washington through its Center for Commercialization, BloodworksInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Patent number: 10073102Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: GrantFiled: February 17, 2017Date of Patent: September 11, 2018Assignees: University of Washington through its Center for Commercialization, BloodworksInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Publication number: 20180043029Abstract: Polymeric carriers for the delivery of therapeutic agents and methods for making and using the same. The polymeric carriers include copolymers, diblock copolymers, polymeric architectures that include the copolymers and diblock copolymers, and particles assemblies comprising the copolymers, diblock copolymers, and polymeric architectures that include the copolymers.Type: ApplicationFiled: November 12, 2015Publication date: February 15, 2018Applicant: University of WashingtonInventors: Patrick S. Stayton, Anthony J. Convertine, Daniel M. Ratner, Debobrato Das, Selvi Srinivasan
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Publication number: 20170227555Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: ApplicationFiled: February 17, 2017Publication date: August 10, 2017Applicants: University of Washington through its Center for Commercialization, Puget Sound Blood CenterInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Patent number: 9599613Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: GrantFiled: July 20, 2012Date of Patent: March 21, 2017Assignees: University of Washington through its Center for Commercialization, Puget Sound Blood CenterInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Patent number: 9518956Abstract: Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface.Type: GrantFiled: July 27, 2015Date of Patent: December 13, 2016Assignee: University of WashingtonInventors: Jae-Hyun Chung, Woonhong Yeo, Kyong-Hoon Lee, Jeffrey W. Chamberlain, Gareth Fotouhi, Shieng Liu, Kie Seok Oh, Daniel M. Ratner, Dayong Gao, Fong-Li Chou
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Publication number: 20160279251Abstract: Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.Type: ApplicationFiled: November 12, 2014Publication date: September 29, 2016Applicant: University of Washington through its Center for CommercializationInventors: Patrick S. Stayton, Anthony Convertine, Daniel M. Ratner, Selvi Srinivasan, Debobrato Das, Fang-Yi Su, Jasmin Chen, David Yee-Shawn Chiu, Daniel Douglas Lane
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Publication number: 20160025677Abstract: Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface.Type: ApplicationFiled: July 27, 2015Publication date: January 28, 2016Applicant: UNIVERSITY OF WASHINGTONInventors: Jae-Hyun Chung, Woonhong Yeo, Kyong-Hoon Lee, Jeffrey W. Chamberlain, Gareth Fotouhi, Shieng Liu, Kie Seok Oh, Daniel M. Ratner, Dayong Gao, Fong-Li Chou
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Patent number: 9097664Abstract: Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface.Type: GrantFiled: December 13, 2013Date of Patent: August 4, 2015Assignee: University of WashingtonInventors: Jae-Hyun Chung, Woonhong Yeo, Kyong-Hoon Lee, Jeffrey W. Chamberlain, Gareth Fotouhi, Shieng Liu, Kie Seok Oh, Daniel M. Ratner, Dayong Gao, Fong-Li Chou
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Publication number: 20140315760Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: ApplicationFiled: July 20, 2012Publication date: October 23, 2014Applicants: PUGET SOUND BLOOD CENTER, University of Washington through its Center for CommercializationInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Publication number: 20140251808Abstract: Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface.Type: ApplicationFiled: December 13, 2013Publication date: September 11, 2014Applicant: University of WashingtonInventors: Jae-Hyun Chung, Woonhong Yeo, Kyong-Hoon Lee, Jeffrey W. Chamberlain, Gareth Fotouhi, Shieng Liu, Kie Seok Oh, Daniel M. Ratner, Dayong Gao, Fong-Li Chou
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Publication number: 20140235790Abstract: Provided herein are compositions and methods for intracellular delivery. The compositions are polymer compositions in which the polymer serves as a carrier for therapeutic and/or diagnostic agents. The polymer compositions are effective in targeted delivery of therapeutic and/or diagnostic agents to a cell. The polymer compositions include a targeting moiety that includes carbohydrate groups that effectively target specific cell surface receptors. The polymer compositions also include an agent binding moiety that effectively associates the therapeutic and/or diagnostic agent to be delivered to the cell.Type: ApplicationFiled: June 11, 2012Publication date: August 21, 2014Applicant: University of Washington through its Center for CommercializationInventors: Patrick Stayton, Matthew Manganiello, Anthony Convertine, Daniel M. Ratner, Yu-Hua Chow, Eun-Ho Song, Bilal Ghosn, Lynn Schnapp, Salka Keller, Debashish Roy
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Patent number: 8632669Abstract: Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface.Type: GrantFiled: June 8, 2009Date of Patent: January 21, 2014Assignee: University of WashingtonInventors: Jae-Hyun Chung, Woonhong Yeo, Kyong-Hoon Lee, Jeffrey W. Chamberlain, Gareth Fotouhi, Shieng Liu, Kie Seok Oh, Daniel M. Ratner, Dayong Gao, Fong-Li Chou
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Publication number: 20090301883Abstract: Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface.Type: ApplicationFiled: June 8, 2009Publication date: December 10, 2009Applicant: UNIVERSITY OF WASHINGTONInventors: Jae-Hyun Chung, Woonhong Yeo, Kyong-Hoon Lee, Jeffrey W. Chamberlain, Gareth Fotouhi, Shieng Liu, Kie Seok Oh, Daniel M. Ratner, Dayong Gao, Fong-Li Chou