Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.

Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.

Abstract: Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.

Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.

Abstract: Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.

Abstract: Disclosed are methods, devices and systems for biological and chemical sample processing using microfluidic chips. The disclosed microfluidic chips contain at least two detection zones for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens to determine their presence in the sample. Systems are also described comprising a cassette having at least one port and a sample inlet in fluid communication with a detection zone for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens, or mixtures thereof, if present, in a sample. Methods for concurrent testing of at least two of RNA, DNA, antibody, and antigen in a sample are also described, as are methods for testing for pre-selected pathogens and microfluidic methods.

Abstract: The invention is directed to compositions comprising polyvalent complexes containing a biocompatible polymer backbone to which is attached a plurality of monomeric anti-microbial peptides and to methods for using such complexes to stabilize anti-microbial peptides for treating or preventing a disease or condition resulting from infection with a microbe. Multivalent derivatives of existing antimicrobial peptides in which several peptides are covalently linked have been investigated. The resulting construct may contain up to 30 or more units, and exhibits a significant enhancement of anti-microbial effect relative to the free peptides: on the order of a ten fold improvement in effectiveness, suggesting that higher multimerization can indeed lead to more effective agents.

Abstract: There is provided methods for inhibiting the activity of enveloped viruses, treatment of viral infections and method inactivating sperm. There is provided articles for use in these methods.

Abstract: The invention includes compositions comprising substantially purified salivary glycoproteins and carbohydrate ligands thereof which are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies and kits useful in the treatment and prevention of HIV-1 infection.

Abstract: A remotely controlled drug delivery device administers a dose of a drug, agent or microbicide using a gas pressure delivery system. The device stores multiple doses of the drug or agent. A toroid shaped housing includes three chambers, a gas chamber containing a pressurized gas, a drug storage chamber containing the drug or agent, and an expandable chamber for delivering the drug from the drug storage. The device includes an electronic controller for opening a valve connecting the gas chamber to the expandable chamber for a predetermined period of time in order to deliver a predetermined dose of the drug. The controller communicates with a remote control device via radio frequency. The remote control device sends a signal to the controller, which causes a dose to be delivered. The controller returns a signal to the remote control device indicating that the dose has been delivered and a signal indicating when the device needs to be removed for maintenance.

Abstract: There is provided methods for inhibiting the activity of enveloped viruses, treatment of viral infections and method inactiviting sperm. There is provided articles for use in these methods.