Abstract: A permission based media system to perform operations that include: presenting a first media object at a client device associated with a user account, the first media object including a reference that identifies the user account; receiving an input that selects the first media object from the client device; determining a permission of the user account based on the reference that identifies the user account; presenting a set of options based on the permission associated with the user account; receiving a selection of an option from among the set of options; and generating a second media object based on the first media object and the selection of the option, according to certain embodiments.

Abstract: The present disclosure generally relates to oral care systems and devices. An oral care system includes a container defining an interior portion and a moveable funnel configured to slide in the interior portion of the container. The moveable funnel includes a funnel portion having a base connected to a tube, where a distal end of the tube includes a cutting edge angled relative to a central axis of the tube. The system further includes a toothbrush supported by the tube, the toothbrush having a handle extending out from the container.

Abstract: Aspects of the present disclosure involve a system comprising a computer-readable storage medium storing a program and method for providing reduced availability modes in messaging. The program and method provide for maintaining a count of consecutive time periods in which message content has been exchanged between a first user and a second user in a messaging application; receiving, from a device associated with the first user, a request to set an availability mode for the first user to a reduced availability mode with respect to the messaging application; setting, in response to receiving the request, the availability mode for the first user to the reduced availability mode; and refraining from updating the count while the availability mode is set to the reduced availability mode.

Abstract: Apparatus and methods of forming boxes from template blanks includes moving the blank forward on a drive line while one or more side panel fingers raise and lower various side panels of the blank in an alternating fashion. One or more holders maintain the side panels in position as the blank moves forward on the drive line. The raised and lowered side panels rigidify various panels from which they extend. The rigidified panels may be less susceptible to bending along false scores that extend transversely across the blank during folding and bending steps of the box forming process.

Abstract: Disclosed herein is a method of administering to a patient in need thereof a therapeutically effective amount of an extracellular thiol isomerase inhibitor compound to treat or prevent a disease or condition influenced by the activity of one or more extracellular thiol isomerases (e.g. protein disulfide isomerase, ERp5, ERp57, ERp72 and thioredoxin). The disease or condition includes arterial thrombosis, venous thrombosis, a thrombotic disease, a cancer, an infectious disease, a viral disease, an immune disorder, inflammation, a neurologic disease, and a neurodegenerative disorder.

Abstract: A photosensitizer formulation can be disposed on or in a mesh; net; netting; screen; curtain of strands, fibers, or monofilaments; substrate, personal protective gear, mask, or any other suitable object. The photosensitizer formulation, when in contact with molecular oxygen and activated by light or ultrasound, produces microbicidal singlet oxygen. A variety of different arrangements and applications are described. For example, an air flow device may also be included to generate a flow of air through or over the photosensitizer formulation. A fluorescent formulation may be included to monitor photobleaching. The photosensitizer formulation may be disposed in a concentration gradient to generate antigenic particles by damaging or destroying microbes.

Abstract: Systems, methods, and computer-readable storage media for locking-in currency exchanges. One method includes providing, by a graphical user interface (GUI) of a wallet application, a customer request, wherein the customer request is a request for a currency transfer between a customer account of the customer to a recipient account of a recipient, wherein the customer account is associated with a first type of currency and the recipient account is associated with a second type of currency, presenting, by the GUI of the wallet application, a locked-in exchange rate for a time limit and data corresponding to the exchange rate and the time limit, exchanging, by the wallet application, an amount of the first type of currency for an amount of the second type of currency based on the exchange rate, and receiving, by the GUI of the wallet application, an indication of a transferred amount for a currency transfer.

Abstract: The present invention relates to peptide conjugates of microtubule-targeting agents such as maytansinoid derivatives which are useful for the treatment of diseases such as cancer.

Abstract: In one embodiment, an information technology (IT) equipment enclosure comprises a first portion of a chassis configured with one or more compute devices fixedly mounted to the chassis and a second portion of the chassis configured to receive a removable storage tray module, the storage tray module configured with one or more storage devices and one or more cooling devices. The removable storage tray module comprising a handle that is pivotable between a locked position and an unlocked position. The handle comprises a recessed portion that is configured to route cables to the storage devices when the handle is in the locked position. The handle may engage a sidewall of the chassis when in the locked position. The cooling devices are selected based upon the one or more storage devices on the storage tray module. The cooling devices may be fans.

Abstract: A permission based media system to perform operations that include: presenting a first media object at a client device associated with a user account, the first media object including a reference that identifies the user account; receiving an input that selects the first media object from the client device; determining a permission of the user account based on the reference that identifies the user account; presenting a set of options based on the permission associated with the user account; receiving a selection of an option from among the set of options; and generating a second media object based on the first media object and the selection of the option, according to certain embodiments.

Abstract: A turbomachine for an aircraft extending axially along an axis X comprising a primary flow path in which an air stream flows intended for the combustion chamber and a secondary flow path in which an air stream flows intended for propulsion, the compressor comprising a plurality of first variable bypass valves, a plurality of second variable bypass valves, the turbomachine comprising a first control system configured to control the movement of the plurality of first variable bypass valves and a second control system configured to control the movement of the plurality of second variable bypass valves, the first control system and the second control system being separate.

Abstract: An optical detection device is included in a self-guided flying vehicle, the self-guided flying vehicle being composed of a cone located at the head of the self-guided flying vehicle, a propulsion device located at the rear of the self-guided flying vehicle and a body located between the cone and the propulsion device. The optical detection device includes at least two portholes disposed in a collar on the periphery of the body of the self-guided flying vehicle.

Abstract: An optical detection device is included in a self-guided flying vehicle, the self-guided flying vehicle being composed of a cone located at the head of the self-guided flying vehicle, a propulsion device located at the rear of the self-guided flying vehicle and a body located between the cone and the propulsion device. The optical detection device includes at least two portholes disposed in a collar on the periphery of the body of the self-guided flying vehicle.

Abstract: A device for cardiac valve repair, the device comprising: a stent adapted to anchor to at least one tissue site, the tissue site located upstream with respect to a heart valve of a patient; and a neo-leaflet arranged to extend from the upstream anchoring means, the neo-leaflet comprising a free end, wherein the neo-leaflet is operable to extend across the heart valve via a commissure in between two heart valve leaflets of the patient's heart and locate the free end downstream from the heart valve and the neo-leaflet operable to coapt with the heart valve leaflets of the patient's heart to prevent and/or minimize a backflow of blood. The present invention is suitable for the treatment of heart valves using minimally invasive approaches. Additionally, the present invention is directed to a method of implanting a device for cardiac valve repair in a patient's heart.

Abstract: The present invention relates to determining a treatment response index. In order to improve and facilitate hypertension treatment procedures, a device (10) for determining a treatment response index is provided that comprises a data input (12), a data processor (14) and a data output (16). The data input is configured to receive a value (18) of at least one first measurement of a physiological parameter of a subjects vasculature under a first condition; and to provide a value (20) of at least one second measurement of the physiological parameter of the vasculature under a second condition. In the second condition, a pre-determined stimulation is provided, and the first condition is non-stimulated or at least differently stimulated. The data processor is configured to generate a treatment response index. In an example, the data output is configured to provide a classification of the subject into one of at least two groups of subjects, based on the treatment response index.

Abstract: The present invention relates to a device for cardiac valve repair, the device comprising: at least one upstream anchoring means adapted to anchor to at least one tissue site, the tissue site located upstream with respect to a heart valve of a patient; and a coaptation structure arranged to extend from the upstream anchoring means, the coaptation structure comprising a free end, wherein the coaptation structure is operable to extend across the heart valve and locate the free end downstream from the heart valve and the coaptation structure operable to coapt with at least one heart valve leaflet of the patient's heart to prevent and/or minimize a backflow of blood. The present invention is suitable for the treatment of heart valves using minimally invasive approaches. Additionally, the present invention is directed to a method of implanting a device for cardiac valve repair in a patient's heart.

Abstract: A turbomachine for an aircraft extending axially along an axis X comprising a primary flow path in which an air stream flows intended for the combustion chamber and a secondary flow path in which an air stream flows intended for propulsion, the compressor comprising a plurality of first variable bypass valves, a plurality of second variable bypass valves, the turbomachine comprising a first control system configured to control the movement of the plurality of first variable bypass valves and a second control system configured to control the movement of the plurality of second variable bypass valves, the first control system and the second control system being separate.

Abstract: The present invention is directed to a process for producing a non-oriented film with improved oxygen barrier property, and to such a non-oriented film. The non-oriented film comprises a polyolefin composition comprising a propylene homo- or copolymer, a hydrocarbon resin and optionally a nucleating agent. The process involves cooling of the extruded film at a certain cooling temperature which is preferably higher than the cooling temperature of a film which has the same components in the same relative amounts apart from not comprising the hydrocarbon resin. The present invention allows the application of a polypropylene based non-oriented film like a cast film (CPP) for packaging of sensitive food.

Abstract: According to the present disclosure, a hydrophobic polymeric composite comprising a hydrophobic polymer matrix with hydrophobically modified particles dispersed therein is provided. The hydrophobically modified particles may be derived from hydrophilic particles modified with organic moieties. The hydrophobically modified particles may also take in the form of core-shell fibers with hydrophilic particles encapsulated inside the core of said fibers or in the form of monolithic fibers embedded with hydrophilic particles. The method for making hydrophobic polymeric composite comprising each of the various hydrophobically modified particles is also provided. The hydrophobic polymer matrix can be chosen from poly(alpha-hydroxyesters), of carbonates, polyurethanes or polyalkanoates. For example, hydrophilic particles, such as barium sulphate, zirconium oxide, tantalum oxide or bismuth oxide, are dispersed in the hydrophobic biodegradable polymers, such as poly-(L-lactide) (PLLA).

Abstract: A bypass turbine engine is described. The engine includes a system for bleeding gas from a primary stream to a secondary stream. The system may include two coaxial rings extending one around the other. A perforated internal first ring may be situated at the level of an outer casing and may extend substantially in a continuation of the outer casing. A perforated external second ring may be mounted such that it slides circumferentially on the first ring between a first position in which the perforations of the rings do not communicate with one another and a second bleed position in which the perforations of the rings communicate with one another.