Patents by Inventor Daniel Mark Spielman

Daniel Mark Spielman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Magnetic resonance spectroscopic imaging method to monitor progression and treatment of neurodegenerative conditions
    Patent number: 6819952
    Abstract: A non-invasive longitudinal method that is sensitive and objective for quantifying progressive loss of neurons in normal aging brains and brains that suffer from a neurodegenerative disease is provided. The method also provides clinicians, patients and drug companies with a method for evaluating the efficacy of various treatments and interventions by assessing a change in brain integrity. The method determines and localizes a change in brain integrity in a compartment of a brain from at least structural images and metabolite brain images, which are acquired for at least two time instances. The time period between two time instances is dependent on the disease pathology and disease progression and could, for instance, be at least 3 months between time instances as well as at least 6 or 12 months between time instances.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: November 16, 2004
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Adolf Pfefferbaum, Elfar Adalsteinsson, Daniel Mark Spielman, Edith V. Sullivan
  • Magnetic resonance spectroscopic imaging method to monitor progression and treatment of neurodegenerative conditions
    Publication number: 20020173713
    Abstract: A non-invasive longitudinal method that is sensitive and objective for quantifying progressive loss of neurons in normal aging brains and brains that suffer from a neurodegenerative disease is provided. The method also provides clinicians, patients and drug companies with a method for evaluating the efficacy of various treatments and interventions by assessing a change in brain integrity. The method determines and localizes a change in brain integrity in a compartment of a brain from at least structural images and metabolite brain images, which are acquired for at least two time instances. The time period between two time instances is dependent on the disease pathology and disease progression and could, for instance, be at least 3 months between time instances as well as at least 6 or 12 months between time instances.
    Type: Application
    Filed: March 22, 2002
    Publication date: November 21, 2002
    Inventors: Adolf Pfefferbaum, Elfar Adalsteinsson, Daniel Mark Spielman, Edith V. Sullivan