Abstract: Passivation regions and device configurations are described herein. The passivation regions can be configured to seal against diffusion of an objective material from an underlying region into and/or through the passivation region. The passivation regions can also be configured to seal against diffusion of an externally sourced or ambient substance into and/or through the passivation region towards the underlying region.

Abstract: Passivation regions and device configurations are described herein. The passivation regions can be configured to seal against diffusion of an objective material from an underlying region into and/or through the passivation region. The passivation regions can also be configured to seal against diffusion of an externally sourced or ambient substance into and/or through the passivation region towards the underlying region.

Abstract: A method of treating or preventing at least one symptom associated with a disease or condition in a subject in need thereof. The method comprising: stimulating a sacral nerve in the subject with an electrode according to a set of stimulation parameters; wherein the set of stimulation parameters is based on a three-dimensional model. The three-dimensional model includes a pelvic organs model, a sacral nerve model, and an electrode model. Electrode designs for stimulating a sacral nerve in a subject in need thereof.

Abstract: Passivation regions and device configurations are described herein. The passivation regions can be configured to seal against diffusion of an objective material from an underlying region into and/or through the passivation region. The passivation regions can also be configured to seal against diffusion of an externally sourced or ambient substance into and/or through the passivation region towards the underlying region.

Abstract: A distance measuring device capable of being used in microscopes or other optical systems. Embodiments of the invention employ one or more scanning mirrors to scan a reference beam over a target to be inspected. The reference beam is returned and detected by a photodetector. The reference beam may be created by using a knife-edge element which allows the outgoing reference beam and incoming reference beam to follow the same path so that the apparent motion of the spot on the target surface is not detected by the photodetector. The photodetector generates an electronic signal corresponding to the displacement of the target away from the ideal focal point. The electronic signal may be used to drive a servomechanism to displace either the target or the microscope objective lens to bring the target in focus.

Abstract: A distance measuring device capable of being used in microscopes or other optical systems. Embodiments of the invention employ one or more scanning mirrors to scan a reference beam over a target to be inspected. The reference beam is returned and detected by a photodetector. The reference beam may be created by using a knife-edge element which allows the outgoing reference beam and incoming reference beam to follow the same path so that the apparent motion of the spot on the target surface is not detected by the photodetector. The photodetector generates an electronic signal corresponding to the displacement of the target away from the ideal focal point. The electrical signal may be used to drive a servomechanism to displace either the target or the microscope objective lens to bring the target in focus.

Abstract: Disclosed are various systems and methods for generating a data signal. In one embodiment, a system is provided that comprises a laser with a gain medium, the laser being configured to emit optical power. The laser is further configured to receive an external optical feedback optically coupled into the gain medium from an optical medium. The external optical feedback is modulated by data embodied in the optical medium. A circuit generates the data signal corresponding to the data based upon a variation in the optical output power of the laser due to the external optical feedback directed into the gain medium of the laser.

Abstract: Disclosed are methods of treating cancer by administration of compounds according to formula (I): wherein the variables R1, R2, R3 and Z are described herein.

Abstract: A combustor includes a combustor head with an integrated counter-flow heat exchanger. The combustor head defines a combustion chamber and has a surface accessible for external delivery of thermal energy. The counter-flow heat exchanger has a fuel channel extending between a fuel inlet and a fuel outlet coupled to the combustion chamber, an exhaust channel extending between an exhaust inlet coupled to the combustion chamber and an exhaust outlet, and a shared wall between the fuel channel and the exhaust channel for transfer of thermal energy therebetween.

Abstract: A method of disbursing fine particles in a spray including the steps of providing a liquid carrier having a critical point and fine particles of at least one material. The fine particles are dispersed in the liquid carrier. A supercritical carrier containing dispersed particles is created by driving the liquid carrier containing dispersed fine particles above the critical point. The pressure of the supercritical carrier containing dispersed particles is reduced thereby forming a vapor carrier containing dispersed particles therein. The vapor carrier containing disbursed fine particles is then discharged.

Abstract: Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the I?B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract: The present invention provides a swallowable data recorder medical device. The swallowable data recorder medical device includes a capsule including a sensing module for sensing a biologic condition within a body. A recording module is provided including an atomic resolution storage device. The recording module is electrically coupled to the sensing module for recording data representative of the sensed biologic condition in the atomic resolution storage device. A power supply is coupled to the recording module.

Abstract: Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the I?B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract: An X-ray generating apparatus comprises a semiconductor structure, an emitter formed on the semiconductor structure, with the emitter to emit electrons. The apparatus further comprises an element to generate X-rays in response to impact by the electrons on the element.