Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.

Abstract: In a general aspect, an integrated quantum circuit includes a first substrate and a second substrate. The first substrate includes a first surface and a recess formed in the first substrate along the first surface. The recess has a recess surface and is configured to enclose a quantum circuit element. The first substrate includes a first electrically-conductive layer disposed on the first surface and covering at least a portion of the recess surface. The first electrically-conductive layer includes a first superconducting material. The second substrate includes a second surface and a quantum circuit element. The second substrate includes a second electrically-conductive layer on the second surface that includes a second superconducting material. The first substrate is adjacent the second substrate to enclose the quantum circuit device within the recess. The first electrically-conductive layer of the first substrate is electrically-coupled to the second electrically-coupled layer of the second substrate.

Abstract: Passivation regions and device configurations are described herein. The passivation regions can be configured to seal against diffusion of an objective material from an underlying region into and/or through the passivation region. The passivation regions can also be configured to seal against diffusion of an externally sourced or ambient substance into and/or through the passivation region towards the underlying region.

Abstract: In a general aspect, a superconducting via for routing electrical signals through a substrate includes the substrate and a layer formed of superconducting material. The substrate has a first orifice disposed on a first surface and a second orifice disposed on a second surface. A cavity extends through the substrate from the first orifice to the second orifice. The layer of superconducting material includes a first portion occluding the first orifice and having an exterior surface facing outward from the substrate. The layer also includes a second portion in contact with a side wall of the cavity and extending to the second orifice. A quantum circuit element may optionally be disposed on the first surface and electrically coupled to the exterior surface of the first portion of the layer.

Abstract: In a general aspect, an integrated quantum circuit includes a first substrate and a second substrate. The first substrate includes a first surface and a recess formed in the first substrate along the first surface. The recess has a recess surface and is configured to enclose a quantum circuit element. The first substrate includes a first electrically-conductive layer disposed on the first surface and covering at least a portion of the recess surface. The first electrically-conductive layer includes a first superconducting material. The second substrate includes a second surface and a quantum circuit element. The second substrate includes a second electrically-conductive layer on the second surface that includes a second superconducting material. The first substrate is adjacent the second substrate to enclose the quantum circuit device within the recess. The first electrically-conductive layer of the first substrate is electrically-coupled to the second electrically-coupled layer of the second substrate.

Abstract: A fluid dispenser includes a dispensation conduit and a refill conduit. A refill system includes a refill reservoir and a refill distribution conduit. The refill distribution conduit is configured for selective fluid coupling with the refill conduit to facilitate refilling of the fluid dispenser.

Abstract: A hop composition can be prepared by admixing wet hops and deaerated water, wherein the water of the hop composition contains less than 500 ppb dissolved oxygen. The resulting hop composition preferably contains 1-30 wt % wet hops and 70-99 wt % added water, wherein the water of the hop composition contains less than 500 ppb dissolved oxygen. A finished beer can be prepared from a hop composition of the invention. Optionally, the hop composition can be frozen before use in preparing a finished beer.

Abstract: Aspects extend to methods, systems, and computer program products for automated task processing with escalation. An overall task to be achieved (e.g., scheduling a meeting) can be broken down into a grouping of (e.g., loosely-coupled) asynchronous sub-tasks. Completing the grouping of sub-tasks completes the overall task. Performance of some sub-tasks can be automated. Other sub-tasks can be escalated for performance by micro workers. When a micro worker is unable to perform a sub-task, the overall task can be escalated to a macro worker. Accordingly, a three tiered approach of automation, micro workers, and macro workers is scalable, cost efficient, and also provides flexibility to accurately handle more complex tasks and sub-tasks.

Abstract: A dynamic digital montage system assists a user in creating and publishing a montage about one or more specified topics. The system receives an identification of one or more topics of interest from the user, and based on the subject information, collects data from dynamic and static data sources for display in dedicated sections of a montage. The data is presented in one of a number of predefined but editable layouts for presentation to a user. In one implementation, at least one of the montage components is associated with a dynamic data source and is updated when new data is provided by the dynamic data source. In another implementation, the data sources attached to the montage components are analyzed on a periodic basis, and based on the analysis, data source assignments and/or the montage layout is revised.

Abstract: A fluid dispenser includes a dispensation conduit and a refill conduit. A refill system includes a refill reservoir and a refill distribution conduit. The refill distribution conduit is configured for selective fluid coupling with the refill conduit to facilitate refilling of the fluid dispenser.

Abstract: A storage system (10) for storing a plurality of single-serve-beverage cartridges (30). The system 10 includes a drawer (40) with compartment lanes (50) adapted to allow a plurality of the cartridges to be single-file situated therein. A slide (80) can be used to move the drawer (40) between a closed position and an opened position.

Abstract: Techniques for facilitating personal audio productions, such as verbalized recordings of stories. One representative technique includes a computer-implemented method, including presenting recording prompts each suggestive of a response topic. Spoken audio segments are stored in response to respective ones of the recording prompts. The spoken audio segments may thereafter be assembled into a unitary audio file for transmission.

Abstract: A storage system (10) is provided for storing a plurality of single-serve-beverage cartridges (30). The system 10 comprises a drawer (40) with compartment lanes (50) adapted to allow a plurality of the cartridges to be single-file situated therein. A slide (80) can be used to move the drawer (40) between a closed position and an opened position.

Abstract: A dynamic digital montage system assists a user in creating and publishing a montage about one or more specified topics. The system receives an identification of one or more topics of interest from the user, and based on the subject information, collects data from dynamic and static data sources for display in dedicated sections of a montage. The data is presented in one of a number of predefined but editable layouts for presentation to a user. In one implementation, at least one of the montage components is associated with a dynamic data source and is updated when new data is provided by the dynamic data source. In another implementation, the data sources attached to the montage components are analyzed on a periodic basis, and based on the analysis, data source assignments and/or the montage layout is revised.