Abstract: The present invention relates to peripheral perfusion measurement. In order to provide more detailed peripheral perfusion characteristics for better knowledge about a current situation, a device (10) for peripheral perfusion measurement is provided that comprises an image data input (12), a data processor (14) and an output interface (16). The image data input receives at least one perfusion angiographic 2D X-ray image of a region of interest of a subject's foot and a 3D foot-model comprising spatial perfusion-related parameters. The data processor registers the 3D foot-model with the foot in the at least one perfusion angiographic X-ray image. The registering comprises a pose-estimation of the foot in the 2D X-ray image. The information is mapped between the 2D image and the 3D foot-model based on the pose-estimation. Image processing modification instructions are identified based on the mapped information.

Abstract: The invention relates to polymerizable compositions that are suitable for preparing polyisocyanurate-based plastics and have an extended worklife as compared to the compositions conventionally used for this purpose.

Abstract: The present application provides a HDAC6 inhibitor for use in treating a degenerative disease associated with the formation of intracellular granules, wherein said granules are formed by the aggregation of a protein selected from the group comprising APP, Tau, Ataxin-2, hnRNPA1, C9orf72, Lamin A/C, Myotilin, Matrin 3, alpha-synuclein, SOD1, FUS, hnRNPA2B1, VCP, TIA1, Desmin and Huntingtin, and wherein said inhibitor inhibits both the CD1 and CD2 of HDAC6.

Abstract: The invention relates to fire-extinguishing foams or concentrates, which include a carbohydrate containing silane surfactant.

Abstract: The present application provides a method for treating an influenza virus infection in a subject characterised in that a therapeutically effective amount of a modulator of the ubiquitin-binding property of HDAC6 is administered to said subject. The present application also provides an antibody binding to HDAC6 and decreasing or blocking its ubiquitin-binding properties for use in treating an influenza virus infection.

Abstract: The method for providing a warning of radiation-dose-relevant space-weather events at cruising altitudes comprises the steps of detecting radiation data of the atmospheric radiation, particularly ionizing radiation in the atmosphere, and providing a radiation model for 3D-spatially resolved estimation of a radiation field at cruising altitudes of the earth's atmosphere by use of a radiation dose rate scale based on a continuous range of values. Moreover, the 3D-spatially resolved rates of the effective radiation dose on the basis of the detected radiation data and the radiation model will be estimated. The radiation dose rate scale is divided, based on a continuous range of values, into a discrete, i.e.

Abstract: A method for the calculation of flight paths taking into consideration events of relevance for the radiation dose comprises the following steps: a) collection of radiation data for atmospheric radiation (10); b) examination of the radiation data and conclusion about an event of relevance for radiation dose generating a temporary increase in exposure; c) creation of a model using the radiation data, wherein the model contains at least one estimate of the geographical location of a region with a radiation intensity increased by the event of relevance for radiation dose; d) determination of flight-relevant parameters; e) calculation of a possible flight path in the light of the flight-relevant parameters taking into consideration the model created in step c), wherein the flight path is adjusted in respect of a reduction of exposure to radiation.

Abstract: The invention relates to fire-extinguishing foams or concentrates, which include a carbohydrate containing silane surfactant.

Abstract: A method for the calculation of flight paths taking into consideration events of relevance for the radiation dose comprises the following steps: a) collection of radiation data for atmospheric radiation (10); b) examination of the radiation data and conclusion about an event of relevance for radiation dose generating a temporary increase in exposure; c) creation of a model using the radiation data, wherein the model contains at least one estimate of the geographical location of a region with a radiation intensity increased by the event of relevance for radiation dose; d) determination of flight-relevant parameters; e) calculation of a possible flight path in the light of the flight-relevant parameters taking into consideration the model created in step c), wherein the flight path is adjusted in respect of a reduction of exposure to radiation.

Abstract: The present application provides a method for treating a neurodegenerative disease in a subject characterised in that a therapeutically effective amount of a modulator of HDAC6 administered to said subject.

Abstract: The method for providing a warning of radiation-dose-relevant space-weather events at cruising altitudes comprises the steps of detecting radiation data of the atmospheric radiation, particularly of the ionized radiation in the atmosphere, and providing a radiation model for 3D-spatially resolved estimation of a radiation field at cruising altitudes of the earth's atmosphere by use of a radiation dose rate scale based on a continuous range of values. Moreover, the 3D-spatially resolved rates of the effective radiation dose on the basis of the detected radiation data and the radiation model will be estimated. The radiation dose rate scale is divided, based on a continuous range of values, into a discrete, i.e.

Abstract: Homozygouse knock-out mice lacking the Aiolos gene are shown to exhibit multiple phenotypes in common with humans suffering from the autoimmune disease Systemic Lupus Erythematosus (SLE). When Aiolos −/− mice are crossed with homozygous knock out mice lacking the OBF-1 transcription factor gene, resultant double knock out mice lack all signs of SLE. Methods of screening for agents active against autoimmune diseases, for example SLE are provided. In vitro methods include screening for antagonists of OBF-1, screening for agents which inhibit binding of OBF-1 to oct-1 or oct-2, screening for agonists or antagonists of Aiolos protein and screening for agents which upregulate expression of Aiolos or downregulate expression of OBF-1. Also disclosed are methods of screening using knock-out mice and B cells from knock-out mice.