Patents by Inventor Daniel McAlister

Daniel McAlister has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12570539
    Abstract: Systems and methods for generating radionuclides, such as radium-224. Systems herein may include a first cartridge having a first opening, a second opening, and a chamber therebetween having a first resin having affinity for thorium-228 and bismuth-212; a second cartridge having a first opening, a second opening, and a chamber therebetween having a second resin having affinity for thorium-228 and bismuth-212, a third cartridge having a first opening, a second opening, and a chamber therebetween comprising a third resin having affinity for thorium-228 and bismuth-212, a fourth cartridge having a first opening, a second opening, and a chamber therebetween having a third resin having affinity for lead-212; wherein a continuous flow path is formed from a top of the first cartridge though the second cartridge, through the third cartridge, and to a bottom of the fourth cartridge during system use.
    Type: Grant
    Filed: September 12, 2025
    Date of Patent: March 10, 2026
    Assignee: PERSPECTIVE THERAPEUTICS, INC.
    Inventors: Edwin A. Sagastume, Michael K. Schultz, Daniel McAlister
  • Publication number: 20260008686
    Abstract: Systems and methods for generating radionuclides, such as radium-224. Systems herein may include a first cartridge having a first opening, a second opening, and a chamber therebetween having a first resin having affinity for thorium-228 and bismuth-212; a second cartridge having a first opening, a second opening, and a chamber therebetween having a second resin having affinity for thorium-228 and bismuth-212, a third cartridge having a first opening, a second opening, and a chamber therebetween comprising a third resin having affinity for thorium-228 and bismuth-212, a fourth cartridge having a first opening, a second opening, and a chamber therebetween having a third resin having affinity for lead-212; wherein a continuous flow path is formed from a top of the first cartridge though the second cartridge, through the third cartridge, and to a bottom of the fourth cartridge during system use.
    Type: Application
    Filed: September 12, 2025
    Publication date: January 8, 2026
    Inventors: Edwin A. SAGASTUME, Michael K. SCHULTZ, Daniel MCALISTER
  • Publication number: 20250372274
    Abstract: Systems and methods for generating radionuclides, such as radium-224, are disclosed herein. Systems herein may include a first cartridge having a first opening, a second opening, and a chamber therebetween having a first resin having affinity for thorium-228 and bismuth-212; a second cartridge having a first opening, a second opening, and a chamber therebetween having a second resin having affinity for thorium-228, a third cartridge having a first opening, a second opening, and a chamber therebetween comprising a third resin having affinity for thorium-228 and bismuth-212, and a fourth cartridge having a first opening, a second opening, and a chamber therebetween having a fourth resin having affinity for lead-212; wherein a continuous flow path is formed from a top of the first cartridge though the second cartridge, through the third cartridge, and to a bottom of the fourth cartridge during system use.
    Type: Application
    Filed: March 6, 2025
    Publication date: December 4, 2025
    Inventors: Edwin A. SAGASTUME, Michael K. SCHULTZ, Daniel MCALISTER, Andrew W. KNIGHT, Madeleine EDDY
  • Publication number: 20250368525
    Abstract: Systems and methods for generating radionuclides, such as radium-224. Systems herein may include a first cartridge having a first opening, a second opening, and a chamber therebetween having a first resin having affinity for thorium-228 and bismuth-212; a second cartridge having a first opening, a second opening, and a chamber therebetween having a second resin having affinity for thorium-228 and bismuth-212, a third cartridge having a first opening, a second opening, and a chamber therebetween comprising a third resin having affinity for thorium-228 and bismuth-212, a fourth cartridge having a first opening, a second opening, and a chamber therebetween having a third resin having affinity for lead-212; wherein a continuous flow path is formed from a top of the first cartridge though the second cartridge, through the third cartridge, and to a bottom of the fourth cartridge during system use.
    Type: Application
    Filed: February 27, 2025
    Publication date: December 4, 2025
    Inventors: Edwin A. SAGASTUME, Michael K. SCHULTZ, Daniel MCALISTER
  • Publication number: 20250277287
    Abstract: A method for separating a lead radioisotope from a mixture comprising the lead radioisotope and a radioisotope of radium or thorium is provided, along with a system comprising a plurality of chromatographic columns. The system can include a first cartridge having a lead-complexing media that preferentially binds the lead radioisotope over radioisotopes of radium or thorium, and a second cartridge having a weak cationic exchange media, where a pH of a loading solution used to load the second cartridge is pH2L, and a pH of an eluent used to elute the lead radioisotope from the second cartridge is pH2E, and pH2L is greater than pH2E. The system can also comprise further third and fourth cartridges with chromatographic media to extract and purify the lead radioisotope, to provide a purified solution of lead radioisotope that can be used for medical and other purposes, such as in the labeling of radiopharmaceutical compounds.
    Type: Application
    Filed: April 22, 2025
    Publication date: September 4, 2025
    Inventors: Edwin A. SAGASTUME, Michael K. SCHULTZ, Daniel MCALISTER, Andrew W. KNIGHT, Madeleine EDDY
  • Patent number: 12312653
    Abstract: A method for separating a lead radioisotope from a mixture comprising the lead radioisotope and a radioisotope of radium or thorium is provided, along with a system comprising a plurality of chromatographic columns. The system can include a first cartridge having a lead-complexing media that preferentially binds the lead radioisotope over radioisotopes of radium or thorium, and a second cartridge having a weak cationic exchange media, where a pH of a loading solution used to load the second cartridge is pH2L, and a pH of an eluent used to elute the lead radioisotope from the second cartridge is pH2E, and pH2L is greater than pH2E. The system can also comprise further third and fourth cartridges with chromatographic media to extract and purify the lead radioisotope, to provide a purified solution of lead radioisotope that can be used for medical and other purposes, such as in the labeling of radiopharmaceutical compounds.
    Type: Grant
    Filed: August 15, 2024
    Date of Patent: May 27, 2025
    Assignee: PERSPECTIVE THERAPEUTICS, INC.
    Inventors: Edwin A Sagastume, Michael K. Schultz, Daniel McAlister, Andrew W. Knight, Madeleine Eddy
  • Publication number: 20250059621
    Abstract: A method for separating a lead radioisotope from a mixture comprising the lead radioisotope and a radioisotope of radium or thorium is provided, along with a system comprising a plurality of chromatographic columns. The system can include a first cartridge having a lead-complexing media that preferentially binds the lead radioisotope over radioisotopes of radium or thorium, and a second cartridge having a weak cationic exchange media, where a pH of a loading solution used to load the second cartridge is pH2L, and a pH of an eluent used to elute the lead radioisotope from the second cartridge is pH2E, and pH2L is greater than pH2E. The system can also comprise further third and fourth cartridges with chromatographic media to extract and purify the lead radioisotope, to provide a purified solution of lead radioisotope that can be used for medical and other purposes, such as in the labeling of radiopharmaceutical compounds.
    Type: Application
    Filed: August 15, 2024
    Publication date: February 20, 2025
    Inventors: Edwin A. SAGASTUME, Michael K. SCHULTZ, Daniel MCALISTER, Andrew W. KNIGHT, Madeleine EDDY
  • Publication number: 20150294541
    Abstract: An instrumented flexible waterside security barrier system secures a waterside infrastructure to detect and localize a breach in the barrier caused by an intruder, thereby permitting a user to perform one or more security actions. The system includes a plurality of panels coupled together and disposed in the waterway, each panel having a plurality of optical fibers and a plurality of wire strength members embedded within a polyurethane layer, and a detection system connected to the plurality of panels to monitor the optical fibers in each panel to detect an attenuation of light in any one of the plurality of optical fibers caused by the breach. The detection system determines a location of the breach in the optical fibers, thereby permitting the user to perform the one or more security actions in response to the breach.
    Type: Application
    Filed: April 15, 2015
    Publication date: October 15, 2015
    Inventors: Jeffrey Vance Wilson, Daniel McAlister, Ian McKissick
  • Patent number: 7186591
    Abstract: A method for encapsulating an assembly with a methyl phenyl silicone rubber compound is provided. In various embodiments, the method can include exposing the assembly to a solvent, plasma etching the assembly, and producing a potting mixture, wherein the potting mixture comprises a methyl phenyl room temperature vulcanization silicone and a curing agent. The method can further include pouring the potting mixture over the assembly while under a vacuum until the assembly is encapsulated, pouring at least two control samples of the potting mixture while under the vacuum, curing the encapsulated assembly and the control samples in a first environment and monitoring the one of the control samples for hardness, and determining whether additional cure time in the first environment is needed based upon the results of the control sample hardness tests.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: March 6, 2007
    Assignee: Honeywell International, Inc.
    Inventors: Lance T. Nehr, Leon L. Vail, Patricia C. Tarr, Daniel McAlister
  • Publication number: 20060292881
    Abstract: A method for encapsulating an assembly with a methyl phenyl silicone rubber compound is provided. In various embodiments, the method can include exposing the assembly to a solvent, plasma etching the assembly, and producing a potting mixture, wherein the potting mixture comprises a methyl phenyl room temperature vulcanization silicone and a curing agent. The method can further include pouring the potting mixture over the assembly while under a vacuum until the assembly is encapsulated, pouring at least two control samples of the potting mixture while under the vacuum, curing the encapsulated assembly and the control samples in a first environment and monitoring the one of the control samples for hardness, and determining whether additional cure time in the first environment is needed based upon the results of the control sample hardness tests.
    Type: Application
    Filed: June 24, 2005
    Publication date: December 28, 2006
    Inventors: Lance Nehr, Leon Vail, Patricia Tarr, Daniel McAlister