Abstract: Methods for increasing immune therapy response and predicting likelihood of cancer metastasis by analyzing the expression of genes associated with replication stress response. In some aspects, cancers are treated with immune checkpoint inhibitors and/or MEK inhibitors. Methods for selecting patients by analyzing the expression of genes associated with a defect in replication stress response are also provided.

Abstract: A solenoid valve having current dependent bi-directional force includes a stator with a channel. An armature is in the stator channel. The armature is movable in a first and second direction. A projection extends from the stator into the channel. When a low current is applied, a flux is generated such that it jumps from the projection to the armature and back to the stator. Thus, the armature is pulled in the first direction. As the current is increased, the projection becomes magnetically saturated and the additional flux as a result of increased current jumps from the stator, at a thinned portion, to the armature then back to the stator. This moves the armature in the second direction, opposite to the first direction.

Abstract: Methods for identifying and treating cancers that are DNA repair, such as homologous recombination (HR) repair, defective or sensitive to PARP inhibitors or platinum-based therapy. In some aspects, DNA repair, such as HR repair, defective cancers are treated with a PARP inhibitor therapy or cisplatin. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided.

Abstract: A solenoid includes a core, a yoke, and a first coil. The first coil is wound around the yoke.

Abstract: Methods for increasing immune therapy response and predicting likelihood of cancer metastasis by analyzing the expression of genes associated with replication stress response. In some aspects, cancers are treated with immune checkpoint inhibitors and/or MEK inhibitors. Methods for selecting patients by analyzing the expression of genes associated with a defect in replication stress response are also provided.

Abstract: A purge valve for an EVAP system has a chamber including an inlet conduit for receiving fuel vapors from an EVAP canister, a first outlet conduit to the engine for the fuel vapors, and a second outlet conduit to the engine for the fuel vapors. Energizing the purge valve at a first current actuates a first armature from a closed position to an open position to open a first opening and allow fuel vapors to flow through the first outlet conduit to the engine, without actuating the second armature from a closed position. Energizing the purge valve at a second current that is greater than the first current actuates a second armature from a closed position to an open position to open the second opening and allow fuel vapors to flow through the second outlet conduit to the engine while maintaining the first armature in the fully open position.

Abstract: A solenoid valve having current dependent bi-directional force includes a stator with a channel. An armature is in the stator channel. The armature is movable in a first and second direction. A projection extends from the stator into the channel. When a low current is applied, a flux is generated such that it jumps from the projection to the armature and back to the stator. Thus, the armature is pulled in the first direction. As the current is increased, the projection becomes magnetically saturated and the additional flux as a result of increased current jumps from the stator, at a thinned portion, to the armature then back to the stator. This moves the armature in the second direction, opposite to the first direction.

Abstract: A purge valve for an EVAP system has a chamber including an inlet conduit for receiving fuel vapors from an EVAP canister, a first outlet conduit to the engine for the fuel vapors, and a second outlet conduit to the engine for the fuel vapors. Energizing the purge valve at a first current actuates a first armature from a closed position to an open position to open a first opening and allow fuel vapors to flow through the first outlet conduit to the engine, without actuating the second armature from a closed position. Energizing the purge valve at a second current that is greater than the first current actuates a second armature from a closed position to an open position to open the second opening and allow fuel vapors to flow through the second outlet conduit to the engine while maintaining the first armature in the fully open position.

Abstract: A solenoid including a first magnetic core and a second magnetic core defining an air gap between. A displaceable ferromagnetic member is within the air gap. The ferromagnetic member magnetically connects the first magnetic core and the second magnetic core to create a magnetic flux path between them. This flux results in an increased pull between the first magnetic core and the second magnetic core. A solenoid coil surrounds at least one of the first magnetic core and the second magnetic core.

Abstract: A golf swing aid apparatus comprises a stretchable strap that pulls a golfer's trailing elbow downward towards his or her torso during a golf downswing. The stretchable strap continues pulling the golfer's trailing elbow towards his or her torso until he or she strikes the golf ball, and then releases so that the golfer is free to follow through without impairment from the stretchable strap.

Abstract: Methods for identifying and treating cancers that are DNA repair, such as homologous recombination (HR) repair, defective or sensitive to PARP inhibitors or platinum-based therapy. In some aspects, DNA repair, such as HR repair, defective cancers are treated with a PARP inhibitor therapy or cisplatin. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided.

Abstract: A golf swing aid apparatus comprises a stretchable strap that pulls a golfer's trailing elbow downward towards his or her torso during a golf downswing. The stretchable strap continues pulling the golfer's trailing elbow towards his or her torso until he or she strikes the golf ball, and then releases so that the golfer is free to follow through without impairment from the stretchable strap.

Abstract: A container configured to protect items during shipping and storage is disclosed. The container includes a cover, a liner, and an inflatable bladder between the liner and the cover. The container further includes a protective plate, which optionally houses one or more pumps to inflate the bladder. The container may also include a retractable handle, which may form part of the pump.

Abstract: An assembly, carrier, and method configured to protect items during shipping and storage is disclosed. The assembly includes inflatable cells to protect the items. The assembly may also include additional protective layers to prevent puncture of the cells.