Abstract: Disclosed herein are methods for providing cell therapy for treating or ameliorating a disease in an individual in need thereof, said methods comprising administering to said individual a cellular composition that comprises an engineered T-cell comprising: a first synthetic polynucleotide comprising a sequence encoding a CRISPR nuclease and an epigenetic enzyme or a functional portion thereof that modifies an epigenetic state; and a second synthetic polynucleotide comprising a sequence encoding a guide RNA (gRNA). Further disclosed herein are methods for reducing or preventing T-cell exhaustion in an individual in need thereof, said method comprising administering to said individual a cellular composition that comprises the engineered T-cell.

Abstract: An apparatus for comminuting solid waste material is provided an includes a casing defining a comminution chamber and being open on opposite sides thereof for permitting the flow of liquid therethrough and a comminutor assembly including cooperating substantially parallel first and second shredding stacks. The comminutor assembly includes first and second parallel shafts rotabably mounted, each including a plurality of cutting elements mounted on said first shaft in interspaced relationship with a plurality of second cutting elements mounted on said second shaft, the cutting elements being positioned between and separated in an axial direction by spacers which are coplanar with the cutting elements of the adjacent stack such that a cutting element from one stack and a spacer from the other stack form a pair of interactive shredding members, wherein the at least one cutting tooth has a plurality of serrations, a tapered profile or a bi-level profile.

Abstract: An apparatus for comminuting solid waste material including a casing defining a comminution chamber and being open on opposite sides thereof for permitting the flow of liquid therethrough. The apparatus including cooperating substantially parallel first and second shafts, each including a plurality of cutting elements mounted on said first shaft in interspaced relationship with a plurality of second cutting elements mounted on said second shaft, each of said cutting elements having at least one cutting tooth thereon, said cutting elements being positioned between and separated in an axial direction by spacers which are coplanar with the cutting elements of the adjacent stack such that a cutting element from one stack and a spacer from the other stack form a pair of interactive shredding members, wherein the spacers have a textured or scalloped outer cylindrical surface.

Abstract: An apparatus for comminuting solid waste material is provided. The apparatus includes a casing and a comminutor assembly including a plurality of cutting elements mounted on said first shaft in interspaced relationship with a plurality of second cutting elements mounted on said second shaft. The casing includes laterally opposed side rails each having a wall extending parallel to the flow direction of the liquid through the comminution chamber, a plurality of planar fins projecting outwardly of said rear wall in the direction of said stack, aligned with the flow direction of the liquid and being spaced from each other in a vertical direction to form slots therebetween, and the planar fins having a leading edge extending from the wall upstream a rearward edge, the rearward edge extending from an outermost portion of the leading edge toward the wall, and the fins have a path ratio greater than 1.55 to 1.

Abstract: An apparatus for comminuting solid waste material including a casing defining a comminution chamber and being open on opposite sides thereof for permitting the flow of liquid therethrough. The apparatus including cooperating substantially parallel first and second shafts, each including a plurality of cutting elements mounted on said first shaft in interspaced relationship with a plurality of second cutting elements mounted on said second shaft, each of said cutting elements having at least one cutting tooth thereon, said cutting elements being positioned between and separated in an axial direction by spacers which are coplanar with the cutting elements of the adjacent stack such that a cutting element from one stack and a spacer from the other stack form a pair of interactive shredding members, wherein the spacers have a textured or scalloped outer cylindrical surface.

Abstract: An apparatus for comminuting solid waste material is provided an includes a casing defining a comminution chamber and being open on opposite sides thereof for permitting the flow of liquid therethrough and a comminutor assembly including cooperating substantially parallel first and second shredding stacks. The comminutor assembly includes first and second parallel shafts rotabably mounted, each including a plurality of cutting elements mounted on said first shaft in interspaced relationship with a plurality of second cutting elements mounted on said second shaft, the cutting elements being positioned between and separated in an axial direction by spacers which are coplanar with the cutting elements of the adjacent stack such that a cutting element from one stack and a spacer from the other stack form a pair of interactive shredding members, wherein the at least one cutting tooth has a plurality of serrations, a tapered profile or a bi-level profile.

Abstract: An apparatus for comminuting solid waste material is provided. The apparatus includes a casing and a comminutor assembly including a plurality of cutting elements mounted on said first shaft in interspaced relationship with a plurality of second cutting elements mounted on said second shaft. The casing includes laterally opposed side rails each having a wall extending parallel to the flow direction of the liquid through the comminution chamber, a plurality of planar fins projecting outwardly of said rear wall in the direction of said stack, aligned with the flow direction of the liquid and being spaced from each other in a vertical direction to form slots therebetween, and the planar fins having a leading edge extending from the wall upstream a rearward edge, the rearward edge extending from an outermost portion of the leading edge toward the wall, and the fins have a path ratio greater than 1.55 to 1.

Abstract: A method and system is provided for identifying and recognizing products such as mail pieces and, more particularly, a method and system of object recognition based mail piece fingerprinting is provided to be used with sorting and/or sequencing processes. The system for identifying product transported through a machine includes a first system configured to extract one or more unique features from each of a plurality of product and a data storage system configured to store the extracted one or more unique features for each of the plurality of product. The system further includes a second system configured to identify each of the plurality of product by matching the stored extracted one or more unique features with subsequently extracted unique features from each of the plurality of product as the plurality of product continue to be conveyed through a transportation system.

Abstract: A method and system is provided for identifying and recognizing products such as mail pieces and, more particularly, a method and system of object recognition based mail piece fingerprinting is provided to be used with sorting and/or sequencing processes. The system for identifying product transported through a machine includes a first system configured to extract one or more unique features from each of a plurality of product and a data storage system configured to store the extracted one or more unique features for each of the plurality of product. The system further includes a second system configured to identify each of the plurality of product by matching the stored extracted one or more unique features with subsequently extracted unique features from each of the plurality of product as the plurality of product continue to be conveyed through a transportation system.

Abstract: Aspects of the disclosure provide a patch identification beacon (PIB) device that can enable location tracking with reduced time and cost. The PIB device can include a first interface coupled to a network. The first interface can be configured to receive signals from the network, and transmit signals to the network. Further, the PIB device can include a second interface coupled to an electronic device, and a controller configured to govern the first interface to transmit a programmable identifier associated with the electronic device over the network.

Abstract: A method for tracking a plurality of bus riders includes assigning each bus rider with a unique identifier upon boarding a bus to indicate a transportation status and recording the unique identifier upon exiting the bus to update the transportation status of each bus rider.