Patents by Inventor Daniel Medynski

Daniel Medynski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PRODUCTION OF RECOMBINANT PLASMINOGEN AND PLASMIN POLYPEPTIDES
    Publication number: 20100144622
    Abstract: Methods of producing properly refolded recombinant plasminogen and plasmin polypeptide are provided. Denatured recombinant plasminogen polypeptide is refolded by first solubilizing the polypeptide with a chaotroph and reducing and oxidizing agents at high pH, followed by refolding in the presence of reduced concentration of chaotroph and reducing and oxidizing agents and in the presence of arginine.
    Type: Application
    Filed: September 28, 2007
    Publication date: June 10, 2010
    Inventors: Xinli Lin, Daniel Medynski
  • Methods for production of recombinant alpha1-antitrypsin
    Publication number: 20070218535
    Abstract: Methods of producing properly folded recombinant ?1-antitrypsin (AAT) polypeptide are provided. Denatured recombinant AAT polypeptide is refolded by first solubilizing the polypeptide with a chaotroph at high pH, followed by refolding in the presence of reduced concentrations of chaotroph and in the presence of PEG, glycerol or sucrose, or a detergent while the pH is slowly reduced and is generally maintained.
    Type: Application
    Filed: November 28, 2006
    Publication date: September 20, 2007
    Inventors: Xinli Lin, Daniel Medynski