Patents by Inventor Daniel Mettefeu

Daniel Mettefeu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-benzyl-1,3-dihydroindol-2-one derivatives, their preparation and the pharmaceutical compositions in which they are present
    Patent number: 5696145
    Abstract: The present invention relates to 1-benzyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## to their preparation and to the pharmaceutical compositions in which they are present. These derivatives have an affinity for the vasopressin and oxytocin receptors.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 9, 1997
    Assignee: Sanofi
    Inventors: Loic Foulon, Georges Garcia, Daniel Mettefeu, Claudine Serradeil-Legal, Gerard Valette
  • 1-benzyl-1,3-dihydro-2H-benzimidazol-2-one derivatives, their preparation and the pharmaceutical compositions containing them
    Patent number: 5661169
    Abstract: The present invention relates to 1-benzyl-1,3-dihydro-2H-benzimidazol-2-one derivatives, of formula: ##STR1## and to the possible salts thereof, to a process for their preparation and to the pharmaceutical compositions containing them.These compounds have an affinity for the vasopressin and/or oxytocin receptors.
    Type: Grant
    Filed: July 5, 1995
    Date of Patent: August 26, 1997
    Assignee: SANOFI
    Inventors: Alain Di Malta, Georges Garcia, Daniel Mettefeu, Richard Roux, Claudine Serradeil-Legal
  • 1-benzyl-1,3-dihydroindol-2-one derivatives, their preparation and the pharmaceutical compositions in which they are present
    Patent number: 5618833
    Abstract: The present invention relates to 1-benzyl-1,3-dihydroindol-2-one derivatives of the formula (I). The invention also relates to preparation of these derivatives as well as to the pharmaceutical compositions in which they are present. These derivatives have an affinity for the vasopressin and oxytocin receptors.
    Type: Grant
    Filed: July 29, 1994
    Date of Patent: April 8, 1997
    Assignee: Sanofi
    Inventors: Lo ic Foulon, Georges Garcia, Daniel Mettefeu, Claudine Serradeil-Legal, G erard Valette
  • 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives
    Patent number: 5585394
    Abstract: The present invention relates to 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives of the formula: ##STR1## to their preparation and to the pharmaceutical compositions in which they are present. These derivatives have an affinity for the vasopressin and oxytocin receptors.
    Type: Grant
    Filed: July 29, 1994
    Date of Patent: December 17, 1996
    Assignee: Sanofi
    Inventors: Alain Di Malta, Georges Garcia, Daniel Mettefeu, Dino Nisato, Richard Roux, Claudine Serradeil-Legal
  • Method of preparing chroman derivatives, and synthesis intermediates
    Patent number: 5116987
    Abstract: The invention describes a method of synthesizing a compound of the formula ##STR1## in which X=O or NR,Z=an electron-attracting group,R=H, CN or NO.sub.2,R.sub.1 +R.sub.2 +N--C.dbd.X=a 5-membered or 6-membered heterocycle, andR.sub.3 =H, R.sub.4 =OH or R.sub.3 +R.sub.4 =a bond,said method involving intermediates of the formula ##STR2## in which R.sub.5 =H, Br or N(R.sub.1)CXR.sub.2. This method of synthesis does not involve the epoxide derivative of the chroman.The novel compounds of formula (IX) form a further subject of the invention.
    Type: Grant
    Filed: September 20, 1991
    Date of Patent: May 26, 1992
    Assignee: Sanofi
    Inventors: Georges Garcia, Daniel Mettefeu, Richard Roux
  • Method of preparing chroman derivatives, and synthesis intermediates
    Patent number: 5071991
    Abstract: The invention describes a method of synthesizing a compound of the formula ##STR1## in which X=O or NR,Z=an electron-attracting group,R=H, CN or NO.sub.2,R.sub.1 +R.sub.2 +N--C.dbd.X=a 5-membered or 6-membered heterocycle, andR.sub.3 =H, R.sub.4 =OH or R.sub.3 +R.sub.4 =a bond,said method involving intermediates of the formula ##STR2## in which R.sub.5 =H, Br or N(R.sub.1)CXR.sub.2. This method of synthesis does not involve the epoxide derivative of the chroman.The novel compounds of formula (IX) form a further subject of the invention.
    Type: Grant
    Filed: December 26, 1989
    Date of Patent: December 10, 1991
    Assignee: Sanofi
    Inventors: Georges Garcia, Daniel Mettefeu, Richard Roux