Patents by Inventor Daniel Mink
Daniel Mink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10590092Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.Type: GrantFiled: September 11, 2017Date of Patent: March 17, 2020Assignee: Basilea Pharmaceutica AGInventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
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Publication number: 20190077771Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.Type: ApplicationFiled: September 11, 2017Publication date: March 14, 2019Inventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
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Patent number: 9783508Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.Type: GrantFiled: July 31, 2013Date of Patent: October 10, 2017Assignee: Basilea Pharmaceutica AGInventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
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Patent number: 9750392Abstract: Dishwasher appliances and vents for dishwasher appliances are provided. The dishwasher appliance includes a chamber for the receipt of articles for cleaning, and a door for selectively opening and closing the dishwasher appliance, the door having an interior wall and a bottom. The dishwasher appliance further includes a conduit disposed within the door. The dishwasher appliance further includes a vent for controlling the egress of fluid from the chamber through the first end, the vent received into the door. The vent includes a generally planer body, and a plurality of aperture assemblies defined in the body. Each of the plurality of aperture assemblies extends generally radially within the plane. The vent further includes a plurality of ribs extending from the body.Type: GrantFiled: February 28, 2014Date of Patent: September 5, 2017Assignee: HAIER US APPLIANCE SOLUTIONS, INC.Inventors: Wilbur Carl Bewley, Jr., Paul Edward Newsom, II, Aaron Daniel Mink
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Patent number: 9150562Abstract: The present invention relates to a process for the preparation of a diol sulfone derivative comprising reaction of a halomethyl substrate with a thio-aryl compound to obtain a thio-ether compound, and oxidizing the thio-ether compound to the corresponding sulfone. In case of a chiral halomethyl substrate, the resulting chiral diol sulfone derivative is suitable as a building block for statin type compounds.Type: GrantFiled: January 13, 2012Date of Patent: October 6, 2015Assignee: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.Inventors: Ben De Lange, Peter Hans Riebel, Michael Wolberg, Dennis Heemskerk, Daniel Mink
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Publication number: 20150245760Abstract: Dishwasher appliances and vents for dishwasher appliances are provided. The dishwasher appliance includes a chamber for the receipt of articles for cleaning, and a door for selectively opening and closing the dishwasher appliance, the door having an interior wall and a bottom. The dishwasher appliance further includes a conduit disposed within the door. The dishwasher appliance further includes a vent for controlling the egress of fluid from the chamber through the first end, the vent received into the door. The vent includes a generally planer body, and a plurality of aperture assemblies defined in the body. Each of the plurality of aperture assemblies extends generally radially within the plane. The vent further includes a plurality of ribs extending from the body.Type: ApplicationFiled: February 28, 2014Publication date: September 3, 2015Applicant: General Electric CompanyInventors: Wilbur Carl Bewley, JR., Paul Edward Newsom, II, Aaron Daniel Mink
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Publication number: 20150239852Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.Type: ApplicationFiled: July 31, 2013Publication date: August 27, 2015Inventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
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Publication number: 20130303779Abstract: The present invention relates to a process for the preparation of a diol sulfone derivative comprising reaction of a halomethyl substrate with a thio-aryl compound to obtain a thio-ether compound, and oxidizing the thio-ether compound to the corresponding sulfone. In case of a chiral halomethyl substrate, the resulting chiral diol sulfone derivative is suitable as a building block for statin type compounds.Type: ApplicationFiled: January 13, 2012Publication date: November 14, 2013Applicant: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.Inventors: Ben De Lange, Peter Hans Riebel, Michael Wolberg, Dennis Heemskerk, Daniel Mink
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Publication number: 20110257358Abstract: The invention relates to a method for preparing ?-caprolactam comprising deacylating N-acyl-6-aminocaproic acid and forming ?-caprolactam. The deacylation may be carried out chemically or biocatalytically. The invention further relates to a host cell, comprising a recombinant vector comprising a nucleic acid sequence encoding an enzyme capable of catalysing the formation of 6-aminocaproic acid from N-acyl-6-aminocaproic acid.Type: ApplicationFiled: October 9, 2009Publication date: October 20, 2011Inventors: Daniel Mink, Rudolf Philippus Maria Guit, Monika Muller, Petronella Catharina Raemakers-Franken
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Publication number: 20110251406Abstract: The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula (1), where X stands for a leaving group, and R1, R2, and R3 each independently stand for an alkyl group with 1-3 carbon atoms from 4-hydroxy-6-X-substituted-methyl-tetrahydropyran-2-one compounds, where X is as defined above, with the aid of an acetalization agent, in the presence of an acid catalyst. The invention also relates to the novel compounds of formula (1) as well as salts and acids to be prepared from these, with the OR3 group in formula (1) being replaced by an OY group, where X, R1 and R2 have the meanings defined above and where Y stands for an alkaline (earth) metal or a substituted or unsubstituted ammonium group or stands for hydrogen, and to the novel compounds of formula (2). The products concerned are, after conversion into the t-butyl ester of 2-(6-hydroxymethyl-1,3-dioxane-4-yl)acetic acid, important as intermediary products in the preparation of statins.Type: ApplicationFiled: June 22, 2011Publication date: October 13, 2011Applicant: AstraZeneca UK Ltd.Inventors: Jacob Hermanus Mattheus Hero KOOISTRA, Hubertus Josephus Marie ZEEGERS, Daniel MINK, Joannes Maria Cornelis Antonius MULDERS
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Patent number: 7989643Abstract: The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula 1, where X stands for a leaving group, and R1, R2, and R3 each independently stand for an alkyl group with 1-3 carbon atoms from 4-hydroxy-6-X-substituted-methyl-tetrahydropyran-2-one compounds, where X is as defined above, with the aid of an acetalization agent, in the presence of an acid catalyst. The invention also relates to the novel compounds of formula 1 as well as salts and acids to be prepared from these, with the OR3 group in formula 1 being replaced by an OY group, where X, R1 and R2 have the meanings defined above and where Y stands for an alkaline (earth) metal or a substituted or unsubstituted ammonium group or stands for hydrogen, and to the novel compounds of formula 2. The products concerned are, after conversion into the t-butyl ester of 2-(6-hydroxymethyl-1,3-dioxane-4-yl)acetic acid, important as intermediary products in the preparation of statins.Type: GrantFiled: November 24, 2009Date of Patent: August 2, 2011Assignee: AstraZeneca UK Ltd.Inventors: Jacob Hermanus Mattheus Hero Kooistra, Hubertus Josephus Marie Zeegers, Daniel Mink, Joannes Maria Cornelis Antonius Mulders
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Patent number: 7732621Abstract: The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140° C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound.Type: GrantFiled: December 22, 2005Date of Patent: June 8, 2010Assignee: DSM IP Assets B.V.Inventors: Andreas Hendrikus Maria De Vries, Johannes Gerardus De Vries, Friso Bernard Jan Van Assema, Ben De Lange, Daniel Mink, David John Hyett, Peter Johannes Dominicus Maas
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Publication number: 20100136339Abstract: The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula 1, where X stands for a leaving group, and R1, R2, and R3 each independently stand for an alkyl group with 1-3 carbon atoms from 4-hydroxy-6-X-substituted-methyl-tetrahydropyran-2-one compounds, where X is as defined above, with the aid of an acetalization agent, in the presence of an acid catalyst. The invention also relates to the novel compounds of formula 1 as well as salts and acids to be prepared from these, with the OR3 group in formula 1 being replaced by an OY group, where X, R1 and R2 have the meanings defined above and where Y stands for an alkaline (earth) metal or a substituted or unsubstituted ammonium group or stands for hydrogen, and to the novel compounds of formula 2. The products concerned are, after conversion into the t-butyl ester of 2-(6-hydroxymethyl-1,3-dioxane-4-yl)acetic acid, important as intermediary products in the preparation of statins.Type: ApplicationFiled: November 24, 2009Publication date: June 3, 2010Applicant: AstraZeneca UK Ltd.Inventors: Jacob Hermanus Mattheus Hero Kooistra, Hubertus Josephus Marie ZEEGERS, Daniel MINK, Joannes Maria Cornelis Antonius MULDERS
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Publication number: 20100068771Abstract: The invention relates to a process for the preparation of an enantiomerically enriched ?-amino alcohol, wherein glycine or a glycine salt and an aldehyde are reacted in the presence of a threonine aldolase and a decarboxylase to form the corresponding enantiomerically enriched ?-aminoalcohol, and wherein at least either the threonine aldolase or the decarboxylase is ?-selective. In a preferred embodiment of the invention at least either the threonine aldolase or the decarboxylase is enantioselective.Type: ApplicationFiled: April 12, 2007Publication date: March 18, 2010Inventors: Martin Schürmann, Daniel Mink, Michael Wolberg
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Patent number: 7642363Abstract: The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula 1, where X stands for a leaving group, and R1, R2, and R3 each independently stand for an alkyl group with 1-3 carbon atoms from 4-hydroxy-6-X-substituted-methyl-tetrahydropyran-2-one compounds, where X is as defined above, with the aid of an acetalization agent, in the presence of an acid catalyst. The invention also relates to the novel compounds of formula 1 as well as salts and acids to be prepared from these, with the OR3 group in formula 1 being replaced by an OY group, where X, R1 and R2 have the meanings defined above and where Y stands for an alkaline (earth) metal or a substituted or unsubstituted ammonium group or stands for hydrogen, and to the novel compounds of formula 2. The products concerned are, after conversion into the t-butyl ester of 2-(6-hydroxymethyl-1,3-dioxane-4-yl)acetic acid, important as intermediary products in the preparation of statins.Type: GrantFiled: February 7, 2005Date of Patent: January 5, 2010Assignee: AstraZeneca UK Ltd.Inventors: Jacob Hermanus Mattheus Hero Kooistra, Hubertus Josephus Marie Zeegers, Daniel Mink, Joannes Maria Cornelis Antonius Mulders
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Publication number: 20090209001Abstract: The invention relates to isolated mutants of enzymes from the group of 2-deoxy-D-ribose 5-phosphate aldolase wild-type enzymes having a productivity factor (as determined by a specific test) which is at least 10% higher than the productivity factor for the corresponding wild-type enzyme from which it is a mutant. The mutants have at least one amino acid substitution at one or more of the positions corresponding to K13, T19, Y49, N80, D84, A93, E127, A128, K146, K160, I166, A174, M185, K196, F200, and S239 in Escherichia coli K12 (EC 4.1.2.4) wild-type enzyme sequence, and/or a deletion of at least one amino acid at the positions corresponding to S258 and Y259 therein, optionally combined with, specific, C-terminal extension and/or N terminal extension.Type: ApplicationFiled: June 2, 2005Publication date: August 20, 2009Applicant: DSM IP ASSET B.V.Inventors: Martin Schüermann, Marcel Gerhardus Wubbolts, Daniel Mink, Michael Wolberg, Johannes Helena Michael Mommers, Stefan Martin Jennewein
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Publication number: 20090043112Abstract: The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140° C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound.Type: ApplicationFiled: December 22, 2005Publication date: February 12, 2009Applicant: DSM IP ASSETS B.V.Inventors: Andreas Hendrikus Maria De Vries, Johannes Gerardus De Vries, Friso Bernard Jan Van Assema, Ben De Lange, Daniel Mink, David John Hyett, Peter Johannes Maas
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Patent number: 7439046Abstract: The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one ?-hydrogen atom and a substituted or unsubstituted aldehyde in the presence of an aldolase and water, the reaction between the substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one ?-hydrogen atom and the substituted or unsubstituted aldehyde being carried out at a carbonyl concentration of at most 6 moles/l of reaction mixture and the final concentration of the 2,4-dideoxyhexose or the 2,4,6-trideoxyhexose being at least 2 mass % of the reaction mixture. The invention also relates to the use of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose obtained by means of a process according to the invention in the preparation of a medicine, particularly in the preparation of a statine.Type: GrantFiled: August 17, 2005Date of Patent: October 21, 2008Assignee: DSM IP Assets B.V.Inventors: Joannes Gerardus Kierkels, Daniel Mink, Sven Panke, Franciscus Alphons Lommen, Dennis Heemskerk
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Patent number: 7423162Abstract: The invention relates to a process for the preparation of (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile from 6-X-substituted-methyl-4-hydroxy-tetrahydro-pyran-2-one, wherein X stands for a leaving group, by reacting 6-X-substituted-methyl-4-hydroxy-tetrahydro-pyran-2-one with a cyanide ion in water and by subsequent lowering of the pH to a pH between 0 and 5. (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile and other compounds obtainable from (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile may suitably be used in the preparation of a pharmaceutical preparation, more in particular in the preparation of statins, more in particular in the preparation of Atorvastatine or a salt thereof, for instance its calcium salt. The invention also relates to (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile and other compounds obtainable therefrom.Type: GrantFiled: April 28, 2004Date of Patent: September 9, 2008Assignee: DSM IP Assets B.V.Inventors: Daniel Mink, Wilhelmus Hubertus Joseph Boesten, Michael Wolberg, Natascha Sereinig
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Publication number: 20060258733Abstract: The invention relates to a process for the preparation of (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile from 6-X-substituted-methyl-4-hydroxy-tetrahydro-pyran-2-one, wherein X stands for a leaving group, by reacting 6-X-substituted-methyl-4-hydroxy-tetrahydro-pyran-2-one with a cyanide ion in water and by subsequent lowering of the pH to a pH between 0 and 5. (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile and other compounds obtainable from (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile may suitably be used in the preparation of a pharmaceutical preparation, more in particular in the preparation of statins, more in particular in the preparation of Atorvastatine or a salt thereof, for instance its calcium salt. The invention also relates to (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile and other compounds obtainable therefrom.Type: ApplicationFiled: April 28, 2004Publication date: November 16, 2006Inventors: Daniel Mink, Wilhelmus Hubertus Boesten, Michael Wolberg, Natasch Sereinig