Abstract: A transparent tubing is provided comprising a longitudinal axis having a center; an inner circumferential surface defining a fluid pathway therethrough for delivering a first medium having a first index of refraction n1; an outer circumferential surface; at least one visual marker; and, at least one integrated lens disposed opposite from the at least one visual marker, the at least one integrated lens configured to direct light from the at least one visual marker for detecting a presence or an absence in the fluid pathway of a second medium having a second index of refraction n2, where n2 is different from the first index of refraction n1. A method of making transparent tubing having at least one integrated lens is also provided.

Abstract: A transparent tubing is provided comprising a longitudinal axis having a center; an inner circumferential surface defining a fluid pathway therethrough for delivering a first medium having a first index of refraction m; an outer circumferential surface; at least one visual marker; and, at least one integrated lens disposed opposite from the at least one visual marker, the at least one integrated lens configured to direct light from the at least one visual marker for detecting a presence or an absence in the fluid pathway of a second medium having a second index of refraction n2, where n2 is different from the first index of refraction n1. A method of making transparent tubing having at least one integrated lens is also provided.

Abstract: Drug infusion systems are disclosed including an infusion head configured to deliver a primary drug and a secondary drug to a patient's subcutaneous tissue. The secondary drug may be provided in a controlled-release material and/or a drug-containing reservoir. Methods for assembling and using such drug infusion systems are also disclosed. The secondary drug may extend the wear time of the drug infusion systems.

Abstract: An applicator assembly for use with a dmg infusion system having multiple wear configurations, including a tethered configuration and a patch configuration. The applicator assembly may be a multi-functional device configured to (1) selectively apply an infusion head and/or a holder to a patients skin and (2) insert an injection device of the infusion head into the patients skin. The drug infusion system may be worn interchangeably in the tethered configuration by placing a dmg delivery device in fluid communication with the infusion head via an intermediate tubing set, or in the patch configuration by coupling the drug delivery device to the holder and placing the dmg delivery device in fluid communication with the infusion head without the intermediate tubing set.

Abstract: The present disclosure relates to drug-delivery apparatuses, and in particular, to a drug-delivery apparatus with a fluidic subsystem that can be used to deliver multiple injections to a patient from a drug container storing a drug fluid. The fluidic subsystem may include multiple injection-needle compartments and re-sealable septa to allow multiple accesses to the drug container, while also preserving the sterility of the drug fluid and of the fluid pathway through which the fluid is delivered to a patient. In some embodiments, the fluidic subsystem may be used to deliver drug fluids that do not contain any preservatives (e.g., non-preserved drugs).

Abstract: The present disclosure relates to a drug-delivery device that is attachable to an infusion set hub that has been pre-inserted into a patient's body. The pre-inserted infusion set hub may be configured to deliver a primary drug such as insulin or an insulin analog. The drug-delivery device may deliver a secondary drug such as a glucagon, an NS AID, or another type of insulin or insulin analog through a cannula of the infusion hub.

Abstract: An insulin infusion set (IIS) device with one or more features designed to achieve longevity in a patients continuous subcutaneous insulin infusion (CSII) site viability. One exemplary feature is an adsorbent material configured to adsorb phenolic excipients (e.g., m-cresol or other preservatives) from the insulin formulation. The adsorbent material may be positioned along a fluid pathway specifically designed to increase and/or extend exposure between the insulin formulation and the adsorbent material. Another exemplary feature is a medicament configured to reduce the patients inflammation or slow the progression of the patients inflammatory response. Yet another exemplary feature is a diffusive catheter configured to deliver the insulin formulation in a diffuse manner.

Abstract: The present disclosure relates to a connector hub adapted for use with an infusion set. The connector hub has a first connector and a second connector. The first connector communicates with a first fluid channel and has a first interface. The second connector communicates with a second fluid channel and has a second interface. Attaching the first and second connectors engages the first and second interfaces and provides fluid communication between the first and second fluid channels. Fluid flows between the medication reservoir and a cannula through the first and second fluid channels. At least one of the connectors may include a repositionable pivot member defining an interface.

Abstract: Tube management devices are disclosed for use with an infusion set having a flexible tube. An exemplary device includes a central spindle defining an axis, a base member, and an upper member. The base member and upper member may project radially outwardly from the central spindle and may be axially spaced apart. The device may include a plurality of retainer members disposed on at least one of the base member and the upper member. The central spindle, the base member, the upper member, and the plurality of retainer members define a toroidal space sized to receive a variable length of the flexible tube.

Abstract: A transparent tubing is provided comprising a longitudinal axis having a center; an inner circumferential surface defining a fluid pathway therethrough for delivering a first medium having a first index of refraction m; an outer circumferential surface; at least one visual marker; and, at least one integrated lens disposed opposite from the at least one visual marker, the at least one integrated lens configured to direct light from the at least one visual marker for detecting a presence or an absence in the fluid pathway of a second medium having a second index of refraction n2, where n2 is different from the first index of refraction n1. A method of making transparent tubing having at least one integrated lens is also provided.

Abstract: The present disclosure relates to a tube management device for an infusion set that includes a holding member attachable to the patient and which defines a holding chamber for the tube. The tube may be engaged and disengaged with the device while the lube is operably connected to convey medication. The device may also allow a) the length of flexible tube controlled by the device and b) the position of the final exit of the tube from the holding member relative to the initial entry of the tube into the holding member to both be selectively adjusted. In some embodiments, tire holding chamber is defined by a plurality of channels which may be either non-intersecting or intersecting channels.

Abstract: An insulin infusion set (IIS) device with one or more features designed to achieve longevity in a patients continuous subcutaneous insulin infusion (CSII) site viability. One exemplary feature is an adsorbent material configured to adsorb phenolic excipients (e.g., m-cresol or other preservatives) from the insulin formulation. The adsorbent material may be positioned along a fluid pathway specifically designed to increase and/or extend exposure between the insulin formulation and the adsorbent material. Another exemplary feature is a medicament configured to reduce the patients inflammation or slow the progression of the patients inflammatory response. Yet another exemplary feature is a diffusive catheter configured to deliver the insulin formulation in a diffuse manner.