Patents by Inventor Daniel N. Fox

Daniel N. Fox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220252502
    Abstract: Disclosed is an integrated biocontainment cell sorter that isolates portions of the cell sorter that can create contamination. Two containment systems are utilized. A main cabinet containment system contains input samples. An aerosol management containment area includes a nozzle chamber with a nozzle and a sort chamber with sort plates and collection media that collect a droplet stream from the nozzle. The main cabinet is maintained at a first low pressure and clean air is recirculated under a positive pressure. The aerosol management containment area is kept at a second low pressure, which is lower than the first pressure, so that contamination does not leak from the aerosol management containment area into the main cabinet containment area. A sliding sash window is located over an access opening in the main cabinet and can be moved to access different portions of the main cabinet without changing the substantially constant first low pressure in the main cabinet.
    Type: Application
    Filed: March 11, 2022
    Publication date: August 11, 2022
    Inventors: Lincoln T. Gulley, Daniel N. Fox, Angela L. Goldfain
  • Patent number: 11307132
    Abstract: Disclosed is an integrated biocontainment cell sorter that isolates portions of the cell sorter that can create contamination. Two containment systems are utilized. A main cabinet containment system contains input samples. An aerosol management containment area includes a nozzle chamber with a nozzle and a sort chamber with sort plates and collection media that collect a droplet stream from the nozzle. The main cabinet is maintained at a first low pressure and clean air is recirculated under a positive pressure. The aerosol management containment area is kept at a second low pressure, which is lower than the first pressure, so that contamination does not leak from the aerosol management containment area into the main cabinet containment area. A sliding sash window is located over an access opening in the main cabinet and can be moved to access different portions of the main cabinet without changing the substantially constant first low pressure in the main cabinet.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: April 19, 2022
    Assignee: Life Technologies Corporation
    Inventors: Lincoln T. Gulley, Daniel N. Fox, Angela L. Goldfain
  • Publication number: 20210364408
    Abstract: Disclosed is a system for use in a flow cytometer for unclogging obstructions in a nozzle from salt crystal formations and clumps of cells or debris. A nozzle system is moved to a docking station so that a nozzle tip is seated in the docking station. Deionized water is pushed through the nozzle in a reverse direction to a waste port so that the nozzle is flushed. The nozzle system can remain in the docked position during nonuse so that salt crystals do not form in or on the nozzle.
    Type: Application
    Filed: May 19, 2021
    Publication date: November 25, 2021
    Inventors: Daniel N. Fox, Nathan M. Fox, Rodney C. Harris
  • Publication number: 20210363979
    Abstract: Disclosed is a dual-stage fluidics system that has reduced pulsation. This system uses inexpensive peristaltic pumps and two reservoirs that dampen pulsations in pressure. Peristaltic pumps are used as air pressure pumps and sheath fluid pumps that are placed between the two pressurized reservoirs and isolate the two reservoirs. Since the two reservoirs are maintained at a substantially even pressure, pulsations are reduced so that the peristaltic pumps essentially provide air flow and sheath fluid flow as needed.
    Type: Application
    Filed: May 19, 2021
    Publication date: November 25, 2021
    Inventors: Daniel N. Fox, Nathan M. Fox
  • Publication number: 20200408667
    Abstract: Disclosed is an integrated biocontainment cell sorter that isolates portions of the cell sorter that can create contamination. Two containment systems are utilized. A main cabinet containment system contains input samples. An aerosol management containment area includes a nozzle chamber with a nozzle and a sort chamber with sort plates and collection media that collect a droplet stream from the nozzle. The main cabinet is maintained at a first low pressure and clean air is recirculated under a positive pressure. The aerosol management containment area is kept at a second low pressure, which is lower than the first pressure, so that contamination does not leak from the aerosol management containment area into the main cabinet containment area. A sliding sash window is located over an access opening in the main cabinet and can be moved to access different portions of the main cabinet without changing the substantially constant first low pressure in the main cabinet.
    Type: Application
    Filed: June 24, 2020
    Publication date: December 31, 2020
    Applicant: Propel Labs, Inc.
    Inventors: Lincoln T. Gulley, Daniel N. Fox, Angela L. Goldfain
  • Patent number: 9927342
    Abstract: Disclosed is a two station system for a flow cytometer that includes a sample station and a wash station. During washing, the user has access to the sample station to insert a new sample. This increases the efficiency of the workflow process. Rotary clamps are used to automatically clamp the sample station and wash station to the system. A low volume pressurized cavity is used to bring the pressure of the sample to a desired pressure, which further increases productivity of the system. A transparent body is provided in the sample station so a user can view the sample during the sampling process. A backwash process is used to clean the sample injection tube and the sample uptake tube. In addition, the wash station is designed to rinse the outer surface of the sample uptake tube.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: March 27, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Nathan Michael Gaskill-Fox, Daniel N. Fox, Rodney C. Harris
  • Patent number: 9696257
    Abstract: Disclosed is an automated method and apparatus for automatically setting a drop delay period by detecting calibration particles in a waste stream. The drop delay is incremented over a series of drop delays and the number of calibration particles in the waste stream is detected for each drop delay. The drop delay is selected which has the least number of calibration particles in the waste stream.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: July 4, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Daniel N. Fox, Susan Hunter, Nathan Michael Gaskill-Fox, Kevin P. Raley, Richard A. Miles
  • Patent number: 9592483
    Abstract: Disclosed is a system that can mix deionized water and concentrated sheath fluid to provide sheath fluid in a flow cytometer system having a desired concentration. Flow rates are low, which substantially match the flow rate of sheath fluid through the nozzle, so that turbulence and air bubbles are not formed in the sheath fluid. The available deionized water is then used for back flushing and removal of sample cells and deposited salts from the sheath fluid.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: March 14, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Daniel N. Fox, Nathan Michael Gaskill-Fox
  • Patent number: 9551637
    Abstract: Disclosed is a sheath delivery system that uses a continuous flow of sheath fluid into a pressurized internal reservoir that substantially matches the outflow of sheath fluid through the nozzle of a flow cytometer. A substantially constant level of the sheath fluid is maintained. If the sheath fluid level falls below a desired level, or goes above a desired level, a dampened control system is used to reach the desired level. In addition, air pressure in the pressurized internal container is controlled so that an external sheath container can be removed and refilled with additional sheath fluid without stopping the sheath delivery system 100. Differences in pressure are detected by a droplet camera, which measures the droplet breakoff point to determine the pressure of the sheath fluid in the nozzle.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: January 24, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Daniel N. Fox, Nathan Michael Gaskill-Fox
  • Patent number: 9243995
    Abstract: Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: January 26, 2016
    Assignee: Beckman Coulter, Inc.
    Inventors: Daniel N. Fox, Thomas L. Thrasher
  • Patent number: 9162229
    Abstract: Disclosed is a collection sled for collecting a waste droplet stream 122 in a waste stream catcher that is located below sample collectors. Contamination of collected samples is reduced by collecting the waste droplet stream at a position that is below the sample collectors. A waste trough is provided that gets progressively larger in a downward direction, which prevents backsplash of waste fluid from the collection cavity. Standard sample collector tubes, as well as 8-well strips and microscope slides can be used with the collection sled to collect sample particles.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: October 20, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Nathan Michael Gaskill-Fox, Daniel N. Fox, Rodney C. Harris
  • Patent number: 8980200
    Abstract: Disclosed is a nozzle assembly that is compact in size and that uses plastic tubing as an injection needle. Standard plastic fittings are utilized, which are inexpensive and widely available. The nozzle assembly has a simple construction and can be easily assembled and disassembled in a few minutes by a user. Cleaning and/or replacement of parts is inexpensive. Plastic tubing can be used as an injection needle that has superior qualities over commonly used stainless steel injection needles. Flexure of the injection needle tubing is prevented because of the compact size of the nozzle cavity.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 17, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Daniel N. Fox, Matthias J. G. Ottenberg, Kevin P. Raley, Nathan Michael Gaskill-Fox
  • Patent number: 8754390
    Abstract: A method is provided for generating measurement parameters for a particle sample in a particle analyzer. The method includes, interrogating the particle sample with a triggering interrogator and one or more secondary interrogators respectively positioned along a length of an interrogation area, generating respective pulses based upon the interrogation of a first particle from the particle sample, determining a primary pulse detection window based upon a triggering pulse, determining a search interval to find a secondary pulse based upon factors including the primary pulse detection window and a laser delay, adjusting the search interval for laser delay variation dynamically based on the interrogation of the first particle, identifying the secondary pulse in the adjusted search interval, and processing the secondary pulse to determine a peak value of the secondary pulse. Corresponding apparatus are also provided.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: June 17, 2014
    Assignee: Beckman Coulter, Inc.
    Inventors: Christopher D. Lofstrom, Daniel N. Fox, Thomas L. Thrasher, David C. Neckels
  • Patent number: 8619370
    Abstract: Disclosed is an optical combiner for combining multiple laser beams in a flow cytometer. A dichroic beam combiner is used to combine a second laser beam with a first laser beam so that the two beams are collinear. A beam size adjuster is utilized to adjust the size and convergence/divergence of the second laser beam so that both laser beams focus in a vertical direction at the same location on a stream in the flow cytometer. A cylindrical lens with a vertically oriented axis in the focusable beam shaping optics can also be adjusted to adjust the location of the focus point of the two beams in the horizontal direction. Alignment is maintained with the opto-mechanical adjustments made on one laser beam relative to the other laser beam path. Additional beams can also be added to the optical path.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: December 31, 2013
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Susan Hunter, Daniel N. Fox, Tidhar Sadeh, Matthias J. G. Ottenberg, Kevin P. Raley
  • Publication number: 20130340539
    Abstract: Disclosed is a collection sled for collecting a waste droplet stream 122 in a waste stream catcher that is located below sample collectors. Contamination of collected samples is reduced by collecting the waste droplet stream at a position that is below the sample collectors. A waste trough is provided that gets progressively larger in a downward direction, which prevents backsplash of waste fluid from the collection cavity. Standard sample collector tubes, as well as 8-well strips and microscope slides can be used with the collection sled to collect sample particles.
    Type: Application
    Filed: June 21, 2013
    Publication date: December 26, 2013
    Inventors: Nathan Michael Gaskill-Fox, Daniel N. Fox, Rodney C. Harris
  • Publication number: 20130343965
    Abstract: Disclosed is a nozzle assembly that is compact in size and that uses plastic tubing as an injection needle. Standard plastic fittings are utilized, which are inexpensive and widely available. The nozzle assembly has a simple construction and can be easily assembled and disassembled in a few minutes by a user. Cleaning and/or replacement of parts is inexpensive. Plastic tubing can be used as an injection needle that has superior qualities over commonly used stainless steel injection needles. Flexure of the injection needle tubing is prevented because of the compact size of the nozzle cavity.
    Type: Application
    Filed: June 21, 2013
    Publication date: December 26, 2013
    Inventors: Daniel N. Fox, Matthias J.G. Ottenberg, Kevin P. Raley, Nathan Michael Gaskill-Fox
  • Publication number: 20130343149
    Abstract: Disclosed is a system that can mix deionized water and concentrated sheath fluid to provide sheath fluid in a flow cytometer system having a desired concentration. Flow rates are low, which substantially match the flow rate of sheath fluid through the nozzle, so that turbulence and air bubbles are not formed in the sheath fluid. The available deionized water is then used for back flushing and removal of sample cells and deposited salts from the sheath fluid.
    Type: Application
    Filed: June 20, 2013
    Publication date: December 26, 2013
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Daniel N. Fox, Nathan Michael Gaskill-Fox
  • Publication number: 20130340795
    Abstract: Disclosed is a two station system for a flow cytometer that includes a sample station and a wash station. During washing, the user has access to the sample station to insert a new sample. This increases the efficiency of the workflow process. Rotary clamps are used to automatically clamp the sample station and wash station to the system. A low volume pressurized cavity is used to bring the pressure of the sample to a desired pressure, which further increases productivity of the system. A transparent body is provided in the sample station so a user can view the sample during the sampling process. A backwash process is used to clean the sample injection tube and the sample uptake tube. In addition, the wash station is designed to rinse the outer surface of the sample uptake tube.
    Type: Application
    Filed: June 20, 2013
    Publication date: December 26, 2013
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Nathan Michael Gaskill-Fox, Daniel N. Fox, Rodney C. Harris
  • Publication number: 20130337575
    Abstract: Disclosed is an automated method and apparatus for automatically setting a drop delay period by detecting calibration particles in a waste stream. The drop delay is incremented over a series of drop delays and the number of calibration particles in the waste stream is detected for each drop delay. The drop delay is selected which has the least number of calibration particles in the waste stream.
    Type: Application
    Filed: June 7, 2013
    Publication date: December 19, 2013
    Inventors: Daniel N. Fox, Susan Hunter, Nathan Michael Gaskill-Fox, Kevin P. Raley, Richard A. Miles
  • Publication number: 20130333765
    Abstract: Disclosed is a sheath delivery system that uses a continuous flow of sheath fluid into a pressurized internal reservoir that substantially matches the outflow of sheath fluid through the nozzle of a flow cytometer. A substantially constant level of the sheath fluid is maintained. If the sheath fluid level falls below a desired level, or goes above a desired level, a dampened control system is used to reach the desired level. In addition, air pressure in the pressurized internal container is controlled so that an external sheath container can be removed and refilled with additional sheath fluid without stopping the sheath delivery system 100. Differences in pressure are detected by a droplet camera, which measures the droplet breakoff point to determine the pressure of the sheath fluid in the nozzle.
    Type: Application
    Filed: June 14, 2013
    Publication date: December 19, 2013
    Inventors: Daniel N. Fox, Nathan Michael Gaskill-Fox