Patents by Inventor Daniel NATAF

Daniel NATAF has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETIC ENGNEERING OF B CELL RECEPTORS AND USES THEREOF IN ANTIGEN-INDUCED ANTIBODY SECRETION
    Publication number: 20210269771
    Abstract: The present invention relates to methods and compositions for engineering B cells to express transgenic B cell receptor (BCR) for antigen-induced antibody secretion, compositions, methods and uses thereof in immunotherapy.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 2, 2021
    Inventors: Adi BARZEL, Alessio D. NAHMAD, Tal AKRIV, Miriam FRIED, Iris DOTAN, Daniel NATAF
  • RECOMBINATION ACTIVATING GENE (RAG) INDUCED V(D)J GENE TARGETING
    Publication number: 20200131540
    Abstract: The present invention relates to methods for targeted insertion of at least one nucleic acid sequence/s of interest into a target genomic locus of a mammalian cell. More specifically, the methods of the invention are based on using nucleic acid cassettes comprising the nucleic acid sequence/s of interest and at least one recognition signal sequence (RSS), for insertion of the nucleic acid sequence of interest into the target genomic locus that is mediated by RAG-catalyzed recombination. The invention further provides cassettes, vectors and vehicles and cells comprising said cassettes, compositions and uses thereof in immunotherapy.
    Type: Application
    Filed: April 18, 2018
    Publication date: April 30, 2020
    Inventors: Adi BARZEL, Iris DOTAN, Carmel PUNDAK-MINTZ, Daniel NATAF, Miriam FRIED, Natalia GRITSENKO