Abstract: Aqueous somatotropin compositions are presented that contain less than about 10% of a biologically active somatotropin, water, and glycerol in an amount effective and at a pH effective to maintain the somatotropin substantially completely stable. The somatotropins in such compositions preferably retain their physical and chemical stability for at least 2 years. The somatotropin compositions also preferably have anti-microbial activity, such that, after they have been sterile-filtered, no additional anti-microbial agent is necessary to maintain the sterility of the composition.