Abstract: Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Abstract: Provided herein are methods and devices for grasping and/or tearing trabecular meshwork of an eye of a subject. The devices may include a shaft and a tissue grabber coupled to the shaft. The tissue grabber may include an elongate lower foot configured to be inserted into Schlemm's canal, and a groove configured to grasp a portion of the trabecular meshwork. The methods may include: advancing a tissue grabber to Schlemm's canal of the eye, wherein the tissue gripper comprises a lower foot and a tissue grabbing region; advancing a tip of the lower foot through the trabecular meshwork and into Schlemm's canal; and advancing the lower foot within and relative to Schlemm's canal, wherein as the lower foot is advanced, a portion of the trabecular enters the tissue gripping region, is torn from surrounding tissue, and is collected within the tissue gripping region.

Abstract: Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device, tool, or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Some systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal. Other tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Abstract: Systems and methods for accessing Schlemm's canal, for delivering a fluid composition therein, and for tearing the trabecular meshwork. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. The systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal.

Abstract: Apparatuses and methods of shielding for capacitance-to-digital code conversion are described. One apparatus includes a capacitance-to-digital converter (CDC) for measuring a self-capacitance of a sensor electrode. The capacitance-to-digital code converter can in a first phase, apply a supply voltage to the sensor electrode. The sensor electrode and a shield electrode, the form a mutual capacitance with the sensor electrode. The CDC, in a second phase, couples the shield electrode to a ground potential and the sensor electrode to a first modulation capacitor. The first modulation capacitor is pre-charged to a reference voltage. The CDC, in a third phase, couples the sensor electrode and the shield electrode to the ground potential. The CDC, in a fourth phase, couples the shield electrode to the ground potential and the sensor electrode to a second modulation capacitor. The second modulation capacitor is pre-charged to the reference voltage.

Abstract: Apparatuses and methods of shielding for capacitance-to-digital code conversion are described. One apparatus includes a capacitance-to-digital converter (CDC) for measuring a self-capacitance of a sensor electrode. The capacitance-to-digital code converter can in a first phase, apply a supply voltage to the sensor electrode. The sensor electrode and a shield electrode, the form a mutual capacitance with the sensor electrode. The CDC, in a second phase, couples the shield electrode to a ground potential and the sensor electrode to a first modulation capacitor. The first modulation capacitor is pre-charged to a reference voltage. The CDC, in a third phase, couples the sensor electrode and the shield electrode to the ground potential. The CDC, in a fourth phase, couples the shield electrode to the ground potential and the sensor electrode to a second modulation capacitor. The second modulation capacitor is pre-charged to the reference voltage.

Abstract: Provided herein are methods and devices for grasping and/or tearing trabecular meshwork of an eye of a subject. The devices may include a shaft and a tissue grabber coupled to the shaft. The tissue grabber may include an elongate lower foot configured to be inserted into Schlemm's canal, and a groove configured to grasp a portion of the trabecular meshwork. The methods may include: advancing a tissue grabber to Schlemm's canal of the eye, wherein the tissue gripper comprises a lower foot and a tissue grabbing region; advancing a tip of the lower foot through the trabecular meshwork and into Schlemm's canal; and advancing the lower foot within and relative to Schlemm's canal, wherein as the lower foot is advanced, a portion of the trabecular enters the tissue gripping region, is torn from surrounding tissue, and is collected within the tissue gripping region.

Abstract: Provided herein are methods and devices for grasping and/or tearing trabecular meshwork of an eye of a subject. The devices may include a shaft and a tissue grabber coupled to the shaft. The tissue grabber may include an elongate lower foot configured to be inserted into Schlemm's canal, and a groove configured to grasp a portion of the trabecular meshwork. The methods may include: advancing a tissue grabber to Schlemm's canal of the eye, wherein the tissue gripper comprises a lower foot and a tissue grabbing region; advancing a tip of the lower foot through the trabecular meshwork and into Schlemm's canal; and advancing the lower foot within and relative to Schlemm's canal, wherein as the lower foot is advanced, a portion of the trabecular enters the tissue gripping region, is torn from surrounding tissue, and is collected within the tissue gripping region.

Abstract: Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Abstract: Described here are systems and methods for accessing Schlemm’s canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm’s canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Abstract: Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Abstract: Described here are systems and methods for accessing Schlemm's canal, for delivering a fluid composition therein, and for tearing the trabecular meshwork. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. The systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal.

Abstract: One inductive sensor is configured to maintain a fixed frequency in a resonant circuit. One apparatus includes an inductance-to-digital converter (LDC). The LDC includes a digital filter to measure an inductance change of a sensor and convert the inductance change to a digital value. The LDC further includes a digital control loop to maintain a fixed frequency in the sensor. The sensor forms an oscillator in the digital control loop. An output of the digital control loop is representative of the inductance change of the sensor.

Abstract: Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Abstract: One inductive sensor is configured to maintain a fixed frequency in a resonant circuit. One apparatus includes an inductance-to-digital converter (LDC). The LDC includes a digital filter to measure an inductance change of a sensor and convert the inductance change to a digital value. The LDC further includes a digital control loop to maintain a fixed frequency in the sensor. The sensor forms an oscillator in the digital control loop. An output of the digital control loop is representative of the inductance change of the sensor.

Abstract: Apparatuses and methods of shielding for capacitance-to-digital code conversion are described. One apparatus includes a capacitance-to-digital converter (CDC) for measuring a self-capacitance of a sensor electrode. The capacitance-to-digital code converter can in a first phase, apply a supply voltage to the sensor electrode. The sensor electrode and a shield electrode, the form a mutual capacitance with the sensor electrode. The CDC, in a second phase, couples the shield electrode to a ground potential and the sensor electrode to a first modulation capacitor. The first modulation capacitor is pre-charged to a reference voltage. The CDC, in a third phase, couples the sensor electrode and the shield electrode to the ground potential. The CDC, in a fourth phase, couples the shield electrode to the ground potential and the sensor electrode to a second modulation capacitor. The second modulation capacitor is pre-charged to the reference voltage.

Abstract: Technology directed to low-emissions touch controller in in-cell touch display systems is described. One in-cell touch controller includes a signal generator circuit that is configured to generate a sense signal according to a sensing function, the sense signal including a windowed sinusoidal waveform. The controller generates a transition signal to transition the in-cell touch display between a display function and the sensing function. The controller drives the sense signal and the transition signal on common voltage (VCOM) layer of electrodes during a touch scanning interval. During a display function interval an integrated display driver is configured to drive a first signal on the VCOM layer of electrodes during a display function interval.

Abstract: The present disclosure relates to intraocular implants for treating a condition of the eye, wherein the implant is configured to deliver a drug to the eye. The present disclosure also relates to methods of treating a condition of the eye by delivering a drug from intraocular implants to the posterior chamber (e.g., sulcus), iridocorneal angle, sclera, cornea, limbus, and vitreous.

Abstract: Described here are systems and methods for accessing Schlemm's canal, for delivering a fluid composition therein, and for tearing the trabecular meshwork. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. The systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal.

Abstract: Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.