Patents by Inventor Daniel Offen

Daniel Offen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
    Publication number: 20050265983
    Abstract: A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter synthesis thereby treating the neurodegenerative disorder.
    Type: Application
    Filed: May 17, 2005
    Publication date: December 1, 2005
    Inventors: Eldad Melamed, Daniel Offen, Yosef Levy, Pnina Green
  • Methods of treating and/or preventing autoimmune diseases
    Publication number: 20040235747
    Abstract: The present invention provides methods for preventing and/or treating autoimmune diseases, including multiple sclerosis, in a subject using ADNF polypeptides, by treating the subject with an Activity Dependent Neurotrophic Factor (ADNF) polypeptide.
    Type: Application
    Filed: December 29, 2003
    Publication date: November 25, 2004
    Applicants: Ramot At Tel-Aviv University Ltd., The Govt. of the USA as represented by the Secretary of the Dept. of Health & Human Services
    Inventors: Illana Gozes, Daniel Offen, Eliezer Giladi, Eldad Melamed, Douglas E. Brenneman
  • Treatment of ischemic brain injuries with brain targeted antioxidant compounds
    Publication number: 20030083266
    Abstract: A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to the organism, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.
    Type: Application
    Filed: September 24, 2002
    Publication date: May 1, 2003
    Inventors: Daphne Atlas, Eldad Melamed, Daniel Offen
  • Brain targeted low molecular weight hydrophobic anti oxidant compounds
    Publication number: 20020107176
    Abstract: Novel brain targeted low molecular weight, hydrophobic antioxidants and use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and Creutzfeldt-Jakob's diseases and in treatment of conditions of peripheral tissues, such as acute respiratory distress syndrome, amyotrophic lateral sclerosis, atheroscierotic cardiovascular disease and multiple organ dysfunction, in which oxidants are overproduced.
    Type: Application
    Filed: April 3, 2002
    Publication date: August 8, 2002
    Inventors: Daphne Atlas, Eldad Melamed, Daniel Offen
  • Brain targeted low molecular weight hydrophobic antioxidant compounds
    Patent number: 6420429
    Abstract: Novel brain targeted low molecular weight, hydrophobic antioxidants and use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and Creutzfeldt-Jakob's diseases and in treatment of conditions of peripheral tissues, such as acute respiratory distress syndrome, amyotrophic lateral sclerosis, atheroscierotic cardiovascular disease and multiple organ dysfunction, in which oxidants are overproduced.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: July 16, 2002
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Ramot University Authority for Applied Research & Industrial Development Ltd., MOR-Research Applications Ltd.
    Inventors: Daphne Atlas, Eldad Melamed, Daniel Offen
  • Treatment of ischemic brain injuries with brain targeted anti oxidant compounds
    Patent number: 6369106
    Abstract: A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to the organism, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: April 9, 2002
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Mor-Research Applications Ltd., Ramot University Authority for Applied Research & Industrial Development Ltd.
    Inventors: Daphne Atlas, Eldad Melamed, Daniel Offen