Abstract: The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R1 is —OH, R2 is —NO2 and R3 is H, R4 and R5 are H, one of R6 and R7 is selected from H, —CONH2, and —CONR92, and the other one is selected from —CONR92 and —CONR11R9, wherein R9 and R11 are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off-target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.

Abstract: The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R1 is —OH, R2 is —NO2 and R3 is H, R4 and R5 are H, one of R6 and R7 is selected from H, —CONH2, and —CONR92, and the other one is selected from —CONR92 and —CONR11R9, wherein R9 and R11 are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off-target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.

Abstract: A multi-scale mechanism comprising a rotatable driving shaft; a first scale mounted along the axis of said rotatable driving shaft, said scale including first and second sets of coarse scale divisions for indicating a coarse range of magnitude in two different systems of units as a function of the position of said first scale with respect to said rotatable driving shaft; a second scale for indicating a fine scale range of magnitude in one of said systems of units; a third scale for indicating a fine scale range of magnitude in the other of said systems of units; said third scale operatively connected to said rotatable driving shaft; and a gear assembly connected between said second scale and said third scale having a predetermined gear ratio such that said second scale is caused to move at a different rate than said third scale.

Abstract: A multi-scale mechanism comprising a rotatable driving shaft; a first scale mounted along the axis of said rotatable driving shaft, said scale including first and second sets of coarse scale divisions for indicating a coarse range of magnitude in two different systems of units as a function of the position of said first scale with respect to said rotatable driving shaft; a second scale for indicating a fine scale range of magnitude in one of said systems of units; a third scale for indicating a fine scale range of magnitude in the other of said systems of units; said third scale operatively connected to said rotatable driving shaft; and a gear assembly connected between said second scale and said third scale having a predetermined gear ratio such that said second scale is caused to move at a different rate than said third scale.