Patents by Inventor Daniel Oppenheimer

Daniel Oppenheimer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variants and chemically-modified variants of phenylalanine ammonia-lyase
    Patent number: 7553653
    Abstract: The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: June 30, 2009
    Assignees: BioMarin Pharmaceutical Inc., The Scripps Research Institute
    Inventors: Emilio Kakkis, Daniel Oppenheimer, Paul Fitzpatrick, Robert Heft, Alejandra Gamez, Lin Wang, Woomi Kim, Mary Straub, Marianne Patch, Raymond C. Stevens
  • Methods and compositions for the treatment of metabolic disorders
    Publication number: 20080090832
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Application
    Filed: October 2, 2006
    Publication date: April 17, 2008
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel Oppenheimer, Emil D. Kakkis, Fredric D. Price, Alejandro Dorenbaum
  • Methods and compositions for the treatment of metabolic disorders
    Publication number: 20060040946
    Abstract: The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated.
    Type: Application
    Filed: June 1, 2005
    Publication date: February 23, 2006
    Applicant: BioMarin Pharmaceutical Inc.
    Inventors: Daniel Oppenheimer, Emil Kakkis, Fredric Price, Alejandro Dorenbaum