Abstract: Fc-antigen binding constructs having a CCR4 binding domain and two or more Fc domains are described as are methods for using such constructs. Also described are polypeptides making up such constructs. Fc domain monomers that are included in the constructs can include amino acid substitutions that promote homodimerization or heterodimerization.

Abstract: The present invention relates to methods of using biologically active Fc domain-containing therapeutic constructs (Fc constructs) to induce immune cell activation of the immune response in a subject, and for example, to treat diseases such as cancers and infections in a subject. Such Fc constructs may include 5 or more Fc domains.

Abstract: A system is provided comprising a video stream composer with a data interface, configured to compose a linear video stream from primary content provided by a primary content server and from secondary content provided by one or more secondary content servers; to transmit data representing a linear video stream to one or more client audio-video devices that at least temporarily are data connected to the video stream composer, at least one primary content server and at least one secondary content server; to transmit a linear video stream to a user's audio-video device; to receive and process data signals representing user interactions from a respective client audio-video device; to compose a linear video stream that represents primary content in accordance with a demand received from a client audio-video device when the video stream composer receives a demand; and trigger selection and placement of secondary video content in the linear video stream.

Abstract: The present disclosure relates to engineered IgG Fc constructs and uses thereof.

Abstract: The present invention relates to compositions and methods of engineered IgG Fc constructs, wherein said Fc constructs include one or more Fc domains.

Abstract: The present invention relates to compositions and methods of engineered IgG Fc constructs, wherein said Fc constructs include one or more Fc domains.

Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.

Abstract: The present disclosure relates to engineered IgG Fc constructs and uses thereof.

Abstract: A cleaning assembly for a DOD print head including a main body, a suction hole provided near an outer surface of the main body, the outer surface facing a nozzle plate and the suction hole facing the plurality of nozzles, and a moving mechanism, the outer surface including a contact cleaning element surrounding an outer perimeter the suction hole, an area of a region surface delimited by the contact cleaning element being smaller than an area of the outer surface, the moving mechanism bringing the contact cleaning element in contact with the nozzle plate and moving the main body relative to the print head body along the second direction.

Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.

Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.

Abstract: The present disclosure relates to compositions and methods of engineered IgG Fc constructs, wherein the Fc constructs include one or more Fc domains.

Abstract: Methods for measuring disialylated Fc glycan in a biological sample are described.

Abstract: The present disclosure relates to engineered IgG Fc constructs and uses thereof.

Abstract: The present disclosure relates to compositions and methods of engineered IgG Fc constructs, wherein the Fc constructs include one or more Fc domains.

Abstract: The present disclosure relates to engineered IgG Fc constructs and uses thereof.

Abstract: The present disclosure relates to compositions and methods of engineered Fc-antigen binding domain constructs, where the Fc-antigen binding domain constructs include at least two Fc domains and at least one antigen binding domain.

Abstract: The present invention relates to methods of using biologically active Fc domain-containing therapeutic constructs (Fc constructs) to induce immune cell activation of the immune response in a subject, and for example, to treat diseases such as cancers and infections in a subject. Such Fc constructs may include 5 or more Fc domains.

Abstract: A method is provided for detecting an element. The method includes coupling an element-sugar complex to a substrate. The element-sugar complex includes an element coupled to a sugar. The method includes coupling a lectin to the sugar; detecting the lectin; and detecting the element using at least the detection of the lectin. A system is provided that includes a substrate, and an element-sugar complex coupled to the substrate. The element-sugar complex includes an element coupled to a sugar. The system includes a lectin coupled to the sugar; and detection circuitry to detect the element using at least detection of the lectin.

Abstract: Fc-antigen binding constructs having a CTLA-4 binding domain and two or more Fc domains are described as are methods for using such constructs. Also described are polypeptides making up such constructs.