Patents by Inventor Daniel P. Flaherty

Daniel P. Flaherty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLYL PYRIMIDINONE COMPOUNDS AND THE USES THEREOF
    Publication number: 20230293523
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Application
    Filed: May 22, 2023
    Publication date: September 21, 2023
    Applicant: Purdue Research Foundation
    Inventors: Daniel P. Flaherty, Richard M. van Rijn, Val J. Watts, Jason A. Scott
  • Pyrazolyl pyrimidinone compounds and the uses thereof
    Patent number: 11690844
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: July 4, 2023
    Assignee: Purdue Research Foundation
    Inventors: Daniel P. Flaherty, Richard M. van Rijn, Val J. Watts, Jason A. Scott
  • CARBONIC ANHYDRASE INHIBITORS FOR TREATMENT OF NEISSERIA GONORRHOEAE INFECTION
    Publication number: 20220213047
    Abstract: The invention described generally relates to novel therapeutic compounds, and in particular to carbonic anhydrase inhibitors as an antibiotic against Neisseria gonorrhea bacteria and methods for treating those sexually transmitted infection diseases in mammals using the described carbonic anhydrase inhibitors having a formula (I), or a pharmaceutical formulation thereof, alone or together with one or more other antibiotics.
    Type: Application
    Filed: December 16, 2021
    Publication date: July 7, 2022
    Applicant: Purdue Research Foundation
    Inventors: Daniel P. Flaherty, Mohamed Seleem
  • CARBONIC ANHYDRASE INHIBITORS AND ANTIBIOTICS AGAINST MULTIDRUG RESISTANT BACTERIA
    Publication number: 20220056001
    Abstract: The invention described herein generally relates to novel therapeutic compounds, and in particular to carbonic anhydrase inhibitors as a narrow spectrum antibiotics against drug resistant bacteria and methods for treating those infection diseases in mammals using the described carbonic anhydrase inhibitors or a pharmaceutical formulation thereof.
    Type: Application
    Filed: December 18, 2019
    Publication date: February 24, 2022
    Applicant: Purdue Research Foundation
    Inventors: Daniel P FLAHERTY, Mohamed Seleem, Jatinder Kaur, Xufeng Cao
  • Inhibitors of -linked glycosylation and methods using same
    Patent number: 11219625
    Abstract: The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need thereof. The methods comprise administering to the subject an effective amount of at least one compound of the invention.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: January 11, 2022
    Assignees: YALE UNIVERSITY, THE UNIVERSITY OF KANSAS
    Inventors: Joseph N. Contessa, Jennifer E. Golden, Daniel P. Flaherty
  • PYRAZOLYL PYRIMIDINONE COMPOUNDS AND THE USES THEREOF
    Publication number: 20210100797
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Application
    Filed: October 6, 2020
    Publication date: April 8, 2021
    Applicant: Purdue Research Foundation
    Inventors: Daniel P. Flaherty, Richard M. van Rijn, Val J. Watts, Jason A. Scott
  • Compounds and methods for activating the apoptotic arm of the unfolded protein response
    Patent number: 10787439
    Abstract: N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: September 29, 2020
    Assignees: UNIVERSITY OF KANSAS, THE REGENTS OF THE UNIVERSITY OF MICHIGAN, SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, WAYNE STATE UNIVERSITY
    Inventors: Jennifer E. Golden, Jeffrey Aube, Daniel P. Flaherty, Andrew M. Fribley, Randal J. Kaufman, Thomas D. Y. Chung, Anthony B. Pinkerton, Michael Pablo Hedrick
  • Scaffold of adenylyl cyclase inhibitors for chronic pain and opioid dependence
    Patent number: 10662176
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: May 26, 2020
    Assignee: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel P. Flaherty, Jatinder Kaur
  • NOVEL SCAFFOLD OF ADENYLYL CYCLASE INHIBITORS FOR CHRONIC PAIN AND OPIOID DEPENDENCE
    Publication number: 20190023688
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Application
    Filed: July 18, 2018
    Publication date: January 24, 2019
    Applicant: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel P. Flaherty, Jatinder Kaur
  • ADENYLYL CYCLASE INHIBITORS FOR CHRONIC PAIN AND OPIOID DEPENDENCE
    Publication number: 20190002418
    Abstract: This present application disclosed a series of selective adenylyl cyclase 1 (AC1) inhibitors as a pain therapeutic. Those compounds may provide an effective method of treatment for chronic/inflammatory pain. Those compounds may also prevent opioid dependence and/or reduce opioid dependence. Both method and composition matters are within the scope of this invention.
    Type: Application
    Filed: June 29, 2018
    Publication date: January 3, 2019
    Applicant: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel P. Flaherty, Jatinder Kaur
  • Inhibitors of N-Linked Glycosylation and Methods Using Same
    Publication number: 20190000858
    Abstract: The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need thereof. The methods comprise administering to the subject an effective amount of at least one compound of the invention.
    Type: Application
    Filed: July 22, 2016
    Publication date: January 3, 2019
    Inventors: Joseph N. CONTESSA, Jennifer E. GOLDEN, Daniel P. FLAHERTY
  • Methods and compositions for treating infection
    Patent number: 10004701
    Abstract: Provided herein are compositions and methods for treating or preventing infection.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: June 26, 2018
    Assignees: UNIVERSITY OF ROCHESTER, UNIVERSITY OF KANSAS
    Inventors: Paul M. Dunman, Damian J. Krysan, Daniel P. Flaherty
  • COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE
    Publication number: 20170334889
    Abstract: N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
    Type: Application
    Filed: August 9, 2017
    Publication date: November 23, 2017
    Inventors: Jennifer E. Golden, Jeffrey Aube, Daniel P. Flaherty, Andrew M. Fribley, Randal J. Kaufman, Thomas D.Y. Chung, Anthony B. Pinkerton, Michael Pablo Hedrick
  • Compounds and methods for activating the apoptotic arm of the unfolded protein response
    Patent number: 9732067
    Abstract: N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provided as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: August 15, 2017
    Assignees: University of Kansas, Sanford-Burnham Medical Research Institute, The Regents of the University of Michigan, Wayne State University
    Inventors: Jennifer E. Golden, Jeffrey Aube, Daniel P. Flaherty, Andrew M. Fribley, Randal J. Kaufman, Thomas D. Y. Chung, Anthony B. Pinkerton, Michael Pablo Hedrick
  • METHODS AND COMPOSITIONS FOR TREATING INFECTION
    Publication number: 20170065540
    Abstract: Provided herein are compositions and methods for treating or preventing infection.
    Type: Application
    Filed: November 21, 2016
    Publication date: March 9, 2017
    Applicants: UNIVERSITY OF ROCHESTER, UNIVERSITY OF KANSAS
    Inventors: Paul M. Dunman, Damian J. Krysan, Daniel P. Flaherty
  • Inhibitors of respiratory syncytial virus
    Patent number: 9499496
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for treating a respiratory syncytial virus infection in a subject, or for inhibiting replication of respiratory syncytial virus.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: November 22, 2016
    Assignees: University of Kansas, Southern Research Institute
    Inventors: Jennifer E. Golden, Jeffrey Aube, Denise S. Simpson, Daniel P. Flaherty, Daljit S. Matharu, William E. Severson, Lynn Rasmussen
  • METHODS AND COMPOSITIONS FOR TREATING INFECTION
    Publication number: 20150238473
    Abstract: Provided herein are compositions and methods for treating or preventing infection.
    Type: Application
    Filed: September 27, 2013
    Publication date: August 27, 2015
    Inventors: Paul M. Dunman, Damian J. Krysan, Daniel P. Flaherty
  • COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE
    Publication number: 20150203477
    Abstract: N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
    Type: Application
    Filed: June 18, 2013
    Publication date: July 23, 2015
    Inventors: Jennifer E. Golden, Jeffrey Aube, Daniel P. Flaherty, Andrew M. Fribley, Randal J. Kaufman, Thomas D.Y. Chung, Anthony B. Pinkerton, Michael Pablo Hedrick
  • INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS
    Publication number: 20150119411
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for treating a respiratory syncytial virus infection in a subject, or for inhibiting replication of respiratory syncytial virus.
    Type: Application
    Filed: June 5, 2013
    Publication date: April 30, 2015
    Inventors: Jennifer E. Golden, Jeffrey Aube, Denise S. Simpson, Daniel P. Flaherty, Daljit S. Matharu, William E. Severson, Lynn Rasmussen