Patents by Inventor Daniel P. Getman

Daniel P. Getman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Retroviral protease inhibitors
    Patent number: 5475027
    Abstract: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: December 12, 1995
    Assignee: G.D. Searle & Co.
    Inventors: John J. Talley, Daniel P. Getman, Ko-Chung Lin, Gary A. DeCrescenzo, Donald J. Rogier, Jr., John N. Freskos
  • Retroviral protease inhibitors
    Patent number: 5475013
    Abstract: Urea-containing hydroxyethylamine peptide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: December 12, 1995
    Assignee: Monsanto Company
    Inventors: John J. Talley, Daniel P. Getman, John N. Freskos, Ko-Chung Lin, Robert M. Heintz, Donald J. Rogier, Jr., Deborah E. Bertenshaw
  • Sulfone peroxycarboxylic acids
    Patent number: 5364959
    Abstract: There are disclosed novel, highly stable sulfone peroxycarboxylic acids useful in detergent compositions or alone as bleaching agents which are represented by the formula ##STR1## wherein A and B are organic moieties bonded to the sulfur atom by a carbon atom and one of A and B contains from 1 to 4 ##STR2## groups bonded to carbon atoms.
    Type: Grant
    Filed: September 14, 1992
    Date of Patent: November 15, 1994
    Assignee: Monsanto Company
    Inventors: David R. Dyroff, Daniel P. Getman, Joan K. Glascock
  • Intramolecular carbamate derivative of 2,3-Di-O-blocked-1,4-dideoxy-4-fluoro-nojirimycins
    Patent number: 5273981
    Abstract: Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, alkyl radicals having from 1 to about 10 carbon atoms, alkenyl radicals having from 1 to about 10 carbon atoms, aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.
    Type: Grant
    Filed: April 16, 1992
    Date of Patent: December 28, 1993
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo
  • Synthesis of 1,3-dideoxy-3-fluoronojirimycin
    Patent number: 5218121
    Abstract: Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: June 8, 1993
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo
  • Intermediates for 1,2-dideoxy-2-fluoronojirimycin
    Patent number: 5175168
    Abstract: Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.
    Type: Grant
    Filed: March 22, 1991
    Date of Patent: December 29, 1992
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo
  • Glycosidase inhibiting 1,3-dideoxy-3-fluoronojirimycin
    Patent number: 5130320
    Abstract: Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.
    Type: Grant
    Filed: March 21, 1991
    Date of Patent: July 14, 1992
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo
  • Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin
    Patent number: 5128347
    Abstract: Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, alkyl radicals having from 1 to about 10 carbon atoms, alkenyl radicals having from 1 to about 10 carbon atoms, aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.
    Type: Grant
    Filed: October 18, 1990
    Date of Patent: July 7, 1992
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo
  • 1,3-dideoxy-3-fluoronojirimycin which inhibits glycosidase activity
    Patent number: 5026713
    Abstract: Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: June 25, 1991
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo
  • 1,2-dideoxy-2-fluoronojirimycin as glycosidase inhibitors
    Patent number: 5025021
    Abstract: Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.
    Type: Grant
    Filed: July 27, 1989
    Date of Patent: June 18, 1991
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo
  • Sulfone peroxycarboxylic acids
    Patent number: 5004558
    Abstract: There are disclosed novel, highly stable sulfone peroxycarboxylic acids useful in detergent compositions or alone as bleaching agents which are represented by the formula ##STR1## wherein A and B are organic moieties bonded to the sulfur atom by a carbon atom and one of A and B contains from 1 to 4 ##STR2## groups bonded to carbon atoms.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: April 2, 1991
    Assignee: Monsanto Company
    Inventors: David R. Dyroff, Daniel P. Getman, Joan K. Glascock
  • Process for producing 2,6-disubstituted tyrosine
    Patent number: 4879398
    Abstract: A process for making 2,6-disubstituted tyrosine by the noble metal coupling of a disubstituted aromatic halide or diazonium salt with an amino-protected 2-aminoacrylic acid to form a (Z)-.beta.-(disubstituted phenyl)-.alpha.-acylaminoacrylate, and asymmetrically hydrogenating the acrylate to produce the 2,6-disubstituted tyrosine.
    Type: Grant
    Filed: December 31, 1987
    Date of Patent: November 7, 1989
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Roy A. Periana, Dennis P. Riley
  • Solid phase peptide synthesis
    Patent number: 4879371
    Abstract: A resin and method for using the resin for solid phase peptide synthesis. The resin has a sulfoxide linkage, which is stalbe to strong acid conditions. The sulfoxide linkage can be reduced to a sulfide linkage, which allows cleavage of the peptide from the resin under mild acid conditions.
    Type: Grant
    Filed: June 20, 1988
    Date of Patent: November 7, 1989
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Robert M. Heintz
  • Sulfone peroxycarboxylic acids
    Patent number: 4824591
    Abstract: There are disclosed novel, highly stable sulfone peroxycarboxylic acids useful in detergent compositions alone or as bleaching agents which are represented by the formula ##STR1## wherein A and B are organic moieties bonded to the sulfur atom by a carbon atom and at least one of A and B containing at least one ##STR2## group bonded to a carbon atom.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: April 25, 1989
    Assignee: Monsanto Company
    Inventors: David R. Dyroff, Daniel P. Getman, Joan K. Glascock
  • Resin method for making sulfoxide for solid phase peptide synthesis
    Patent number: 4801665
    Abstract: A resin for solid phase peptide synthesis and a method for synthesizing the resin wherein the resin has a sulfoxide linkage which is stable to strong acid deprotecting conditions. The linkage can be reduced to a sulfide linkage which allows cleavage of the peptide from the resin under mild acid conditions.
    Type: Grant
    Filed: December 30, 1986
    Date of Patent: January 31, 1989
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Robert M. Heintz
  • Resin support for solid phase peptide synthesis
    Patent number: 4764595
    Abstract: A resin and method for using the resin for solid phase peptide synthesis. The resin has a sulfoxide linkage, which is stable to strong acid conditions. The sulfoxide linkage can be reduced to a sulfide linkage, which allows cleavage of the peptide from the resin under mild acid conditions.
    Type: Grant
    Filed: December 24, 1986
    Date of Patent: August 16, 1988
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Robert M. Heintz
  • Resin support for solid phase peptide synthesis
    Patent number: 4764594
    Abstract: A resin and method for preparing the resin for solid phase peptide synthesis. The resin has a sulfoxide linkage, which is stable to strong acid conditions. The sulfoxide linkage can be reduced to a sulfide linkage, which allows cleavage of the peptide from the resin under mild acid conditions.
    Type: Grant
    Filed: March 30, 1987
    Date of Patent: August 16, 1988
    Assignee: Monsanto Company
    Inventor: Daniel P. Getman
  • Sulfone peroxycarboxylic acids
    Patent number: 4758369
    Abstract: There are disclosed novel, highly stable sulfone peroxycarboxylic acids useful in detergent compositions alone or as bleaching agents which are represented by the formula ##STR1## wherein A and B are organic moieties bonded to the sulfur atom by a carbon atom and at least one of A and B containing at least one ##STR2## group bonded to a carbon atom.
    Type: Grant
    Filed: September 17, 1987
    Date of Patent: July 19, 1988
    Assignee: Monsanto Company
    Inventors: David R. Dyroff, Daniel P. Getman, Joan K. Glascock
  • Synthesis of sulfilimines
    Patent number: 4578514
    Abstract: Processes are disclosed for preparation of N-aryl-S,S-dihydrocarbylsulfilimines by reaction of phenylisocyanate compounds with hydrocarbyl sulfoxides. The sulfilimines can be rearranged to ortho-thioalkylene anilines and the reactions can be employed in a route for converting nitrobenzene compounds to ortho-thioalkylene anilines, which are useful intermediates for preparation of herbicidal compounds.
    Type: Grant
    Filed: November 1, 1984
    Date of Patent: March 25, 1986
    Assignee: Monsanto Company
    Inventor: Daniel P. Getman