Abstract: A method of generating a digital twin and of using the digital twin to predict activity of an animate subject. The digital twin is generated from at least system model data and movement data. The digital twin can be activated to simulate a specified activity that the subject is performing or will perform. If desired, the subject can be instructed to perform the same activity while wearing at least one wearable sensor, which is applied to the digital twin. Using artificial intelligence techniques, the activity simulation predicts one or more physical outcomes from the activity.

Abstract: A bone fracture risk analysis, and more particularly, to bone fracture risk prediction using low-resolution clinical CT scans, for example, CT scans having a resolution in a range of 250 to 1000 microns.

Abstract: A method of generating a digital twin and of using the digital twin to predict activity of an animate subject. The digital twin is generated from at least system model data and movement data. The digital twin can be activated to simulate a specified activity that the subject is performing or will perform. If desired, the subject can be instructed to perform the same activity while wearing at least one wearable sensor, which is applied to the digital twin. Using artificial intelligence techniques, the activity simulation predicts one or more physical outcomes from the activity.

Abstract: A method of using a learning machine to provide a biomechanical data representation of a subject based on markerless video motion capture. The learning machine is trained with both markerless video and marker-based (or other worn body sensor) data, with the marker-based or body worn sensor data being used to generate a full biomechanical model, which is the “ground truth” data. This ground truth data is combined with the markerless video data to generate a training dataset.

Abstract: A bone cement formulation comprising: (a) magnetic calcium phosphate nanoparticles present in an amount of 5.0-95 wt. % and having a largest linear dimension of 150 nm to 50 microns; (b) polymerizable acrylate monomer present in an amount of 5.0-95 wt. %; and (c) polyacrylate polymer present in an amount of 0-80 wt. % and having a largest linear dimension from 5.0 to 500 microns. Upon exposure to an alternating magnetic field the formulation is heated which results in polymerization of the acrylate monomer component. The formulation may also be polymerized via the use of chain polymerization initiators.

Abstract: The present disclosure relates to methods of facilitating bone growth. The method may include positioning a device around at least a portion of a bone exhibiting a defect, the device capable of retaining bone segments and micro-structured particles. The method may also include applying micro-structure particles within the device to the defect, wherein each of the micro-structure particles include at least one pore therein. In addition, the method may include aligning at least a portion of the micro-structure particles and applying a polymer to the particles and solidifying the polymer.

Abstract: A bone cement formulation comprising: (a) magnetic calcium phosphate nanoparticles present in an amount of 5.0-95 wt. % and having a largest linear dimension of 150 nm to 50 microns; (b) polymerizable acrylate monomer present in an amount of 5.0-95 wt. %; and (c) polyacrylate polymer present in an amount of 0-80 wt. % and having a largest linear dimension from 5.0 to 500 microns. Upon exposure to an alternating magnetic field the formulation is heated which results in polymerization of the acrylate monomer component. The formulation may also be polymerized via the use of chain polymerization initiators.

Abstract: The present disclosure relates to a bone fracture risk assessment method and system. The method may include generating a volumetric model corresponding to a three-dimensional image of a bone structure for each bone structure in a set of bone structures. The method may further include defining a vector of variables for each bone structure. Each variable in the vector of variables may include a three-dimensional position of one of a number of volumetric vertices and at least one parameter associated with the one volumetric vertex. The method may include generating a set of individual vectors and performing variable reduction on the set of individual vectors. The method may further include determining a discriminator based at least in part on a result of the variable reduction.

Abstract: The present disclosure relates to a bone fracture risk assessment method and system. The method may include generating a volumetric model corresponding to a three-dimensional image of a bone structure for each bone structure in a set of bone structures. The method may further include defining a vector of variables for each bone structure. Each variable in the vector of variables may include a three-dimensional position of one of a number of volumetric vertices and at least one parameter associated with the one volumetric vertex. The method may include generating a set of individual vectors and performing variable reduction on the set of individual vectors. The method may further include determining a discriminator based at least in part on a result of the variable reduction.

Abstract: The present disclosure relates to methods of facilitating bone growth. The method may include positioning a device around at least a portion of a bone exhibiting a defect, the device capable of retaining bone segments and micro-structured particles. The method may also include applying micro-structure particles within the device to the defect, wherein each of the micro-structure particles include at least one pore therein. In addition, the method may include aligning at least a portion of the micro-structure particles and applying a polymer to the particles and solidifying the polymer.