Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

Abstract: A device may receive information associated with an application to be tested. The device may identify test data associated with the application to be tested based on the received information. The device may associate the test data with a plurality of test cases. The device may associate the plurality of test cases with a test set. The device may associate the test set with a release. The device may provide the plurality of test cases and the test data, associated with the release, to the application to be tested. The device may receive a plurality of first results, and may compare the plurality of first results and a plurality of second results. The device may provide information for display based on comparing the plurality of first results and the plurality of second results.

Abstract: A device may receive information associated with an application to be tested. The device may identify test data associated with the application to be tested based on the received information. The device may associate the test data with a plurality of test cases. The device may associate the plurality of test cases with a test set. The device may associate the test set with a release. The device may provide the plurality of test cases and the test data, associated with the release, to the application to be tested. The device may receive a plurality of first results, and may compare the plurality of first results and a plurality of second results. The device may provide information for display based on comparing the plurality of first results and the plurality of second results.

Abstract: A device may receive information associated with an application to be tested. The device may identify test data associated with the application to be tested based on the received information. The device may associate the test data with a plurality of test cases. The device may associate the plurality of test cases with a test set. The device may associate the test set with a release. The device may provide the plurality of test cases and the test data, associated with the release, to the application to be tested. The device may receive a plurality of first results, and may compare the plurality of first results and a plurality of second results. The device may provide information for display based on comparing the plurality of first results and the plurality of second results.

Abstract: A device may receive information associated with an application to be tested. The device may identify test data associated with the application to be tested based on the received information. The device may associate the test data with a plurality of test cases. The device may associate the plurality of test cases with a test set. The device may associate the test set with a release. The device may provide the plurality of test cases and the test data, associated with the release, to the application to be tested. The device may receive a plurality of first results, and may compare the plurality of first results and a plurality of second results. The device may provide information for display based on comparing the plurality of first results and the plurality of second results.

Abstract: A sample encapsulation system includes a base, a chamber having an inlet and a chamber housing in which the chamber is housed. The chamber is fixedly mounted at least in part within the housing and the housing is movably mounted to the base. The system includes a cap, a first ram operably mounted to the cap for engaging the chamber inlet and a second ram positioned in the chamber opposite the inlet. The second ram is movable toward and away from the first ram. The chamber and housing are movable toward the cap for engaging the first ram with the chamber inlet during an encapsulation cycle and away from the cap, disengaging the first ram from the chamber inlet following an encapsulation cycle. The system includes heating and cooling assemblies and a temperature sensor located remotely from the chamber interior to automatically isolate cooling water to the system.

Abstract: A sample encapsulation system includes a base, a chamber having an inlet and a chamber housing in which the chamber is housed. The chamber is fixedly mounted at least in part within the housing and the housing is movably mounted to the base. The system includes a cap, a first ram operably mounted to the cap for engaging the chamber inlet and a second ram positioned in the chamber opposite the inlet. The second ram is movable toward and away from the first ram. The chamber and housing are movable toward the cap for engaging the first ram with the chamber inlet during an encapsulation cycle and away from the cap, disengaging the first ram from the chamber inlet following an encapsulation cycle. The system includes heating and cooling assemblies and a temperature sensor located remotely from the chamber interior to automatically isolate cooling water to the system.

Abstract: A method of forming a conductive ink bridge wire EED on either a flat or curved substrate, wherein a finely detailed bridge wire EED is printed on the substrate using a nano-particle conductive material applied with a commercially available piezoelectric drop-on-demand ink jet printer—which bridge wire is subsequently coated with a first primary explosive layer, an optional second transition explosive layer, and a third secondary explosive layer—such that upon creating a current through the bridge wire EED, the bridge wire is heated and the explosive layers detonate in turn, and in turn initiate the detonation of the device to which the detonator is attached.

Abstract: Some embodiments of the invention comprise a biosensor cartridge which optically, fluidically, and/or mechanically couples to an evanescent sensing measurement apparatus having annularizing illumination elements, said biosensor cartridge and measurement apparatus being used for detecting the presence of chemically or biologically active substances binding to said biosensor present within an aqueous media, such as and without limitation, the presence of specific proteins in blood or urine. Some embodiments comprise an integrated biosensor cartridge having a flow channel and a plurality of storage cavities, fluid flow in the cartridge controlled by valving mechanisms for directing a plurality of fluids through the cartridge, the order and amounts of such fluids passing through the cartridge being externally controlled and required for the detection and measurement of specific chemically or biologically active substances.

Abstract: The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.

Abstract: The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.

Abstract: Based upon given demands, nodes, spans, speed hierarchy, equipment, weights, preferences and constraints, the apparatus and method disclosed creates an optimized network configuration by separating high degree of separation demands and employing functional analysis for equipment selection and functional analysis for demand routing.

Abstract: Based upon given demands, nodes, spans, speed hierarchy, equipment, weights, preferences, and constraints, the apparatus and method disclosed creates an optimized network configuration by (1) separating demands into groups based on their shortest path and the maximum cycle size, (2) routing each demand group, and (3) re-routing the demands on rings that exceed the Cost Threshold when cost effective. Common elements in routing demands in the groups are functional analysis for equipment selection and functional analysis for demand routing.

Abstract: The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.