Abstract: Combination therapies for use in the treatment of brain tumours, particularly glioma and embryonal brain tumours. Disclosed herein are pharmaceutical compositions comprising a complex of Panobinostat and a cyclodextrin, a second pharmaceutical agent, and a pharmaceutically acceptable excipient, diluent or carrier, in which the second pharmaceutical agent is Niclosamide, Dasatinib or Duvelisib. Associated methods of treatment and use are further disclosed.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: A presentation system capable of detecting one or more gestures and contacts on a touch sensitive display. The presentation system can displaying indicia of such contacts, such as when a user writes with a fingertip, and can remove or alter such indicia responsive to other gestures and contacts. The system can accurately distinguish between types of gestures detected, such as between a writing gesture and an erasing gesture, on both large and small touch sensitive displays, thereby obviating the need for a user to make additional selective inputs to transition from one type of gesture to another. The system can determine how long to keep user annotations displayed during a presentation, based on the nature of the gesture used to make the annotations and the context in which they are made.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: In addition to drilling operations a hard rock drill rig is used to induce seismic energy into subsurface rock formations. In quartz rich rock the seismic energy will partially convert to electrical energy thereby allowing for the prospecting of ore-bearing quartz veins. Seismic energy and electric energy are detected by a sensor array. The electric energy is used to infer the presence of piezoelectric materials in the rock formations, and such materials are mapped using the detected seismic energy and electric energy.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: The present invention provides a process for producing nanoparticles, comprising: providing a first liquid comprising a metal salt and at least one species of ligand having a functional group capable of binding to a metal surface, providing a second liquid comprising a reducing agent; providing at least one liquid droplet generator operable to generate liquid droplets, causing the at least one liquid droplet generator to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the second liquid so as to cause the metal salt and the at least one species of ligand to come into contact with the reducing agent, thereby causing self-assembly of nanoparticles, said nanoparticles having a core of said metal and a corona comprising a plurality of said ligands covalently bound to the core. Also provided are nanoparticles produced by the process of the invention and use of such nanoparticles in medicine.

Abstract: A vibration while drilling acquisition and signal processing system include a sensor assembly affixable to a drill string in a drilling unit and a sensor for detecting vibrations in the drill string. A first processor is in signal communication with the sensor and is programmed to digitally sample signals from the sensor. A transmitter in signal communication with the first processor communicates the digitized signals to a device disposed apart from the drill string. The first processor is programmed to operate the signal. An electric power source provides power to the sensor, the first processor and transmitter. Either or both the first processor and a second processor associated with the device is programmed to calculate properties of rock formations using only detected vibration signals from the drill string.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: Respective embodiments disclosed herein include methods and apparatuses (1) for surveying a mine bench or other material body using at least seismic data obtained via geophone and measurement module data synchronized via a wireless link; (2) for generating hyperspectral panoramic imaging data of a blast hole or other borehole; or (3) for allowing a neural network to facilitate a differential blast design that targets a first bench part more weakly than the differential blast design targets a second bench part (along the same mine bench) at least partly based on data indicative of a much higher concentration of a valuable material in the second bench part than in the first.

Abstract: A method for determining properties of rock formations using drill string vibration measurements includes entering into a processor signals corresponding to vibrations detected along a rotating part of a drill string while drilling a borehole. The vibration signals are transformed into transformed signals representing elastic response of the drill string, the rock formations and borehole fluid to a filtered impulse originating at a known location along the drill string. Properties of the rock formations are calculated using the transformed signals.

Abstract: Systems and methods for variable rate steam injection, including via solar power for enhanced oil recovery, are disclosed. Several embodiments include using the variable nature of solar-generated steam to improve the efficiency and cost-effectiveness of enhanced oil recovery processes. In particular embodiments, the variable rate injection can provide more uniform steam distribution in an oil-bearing formation, at a lower cost than if the same amount of steam were provided on a continuous basis.

Abstract: A vibration while drilling acquisition and signal processing system include a sensor assembly affixable to a drill string in a drilling unit and a sensor for detecting vibrations in the drill string. A first processor is in signal communication with the sensor and is programmed to digitally sample signals from the sensor. A transmitter in signal communication with the first processor communicates the digitized signals to a device disposed apart from the drill string. The first processor is programmed to operate the signal. An electric power source provides power to the sensor, the first processor and transmitter. Either or both the first processor and a second processor associated with the device is programmed to calculate properties of rock formations using only detected vibration signals from the drill string.

Abstract: A method for determining properties of rock formations using drill string vibration measurements includes entering into a processor signals corresponding to vibrations detected along a rotating part of a drill string while drilling a borehole. The vibration signals are transformed into transformed signals representing elastic response of the drill string, the rock formations and borehole fluid to a filtered impulse originating at a known location along the drill string. Properties of the rock formations are calculated using the transformed signals.

Abstract: A vibration while drilling acquisition and signal processing system include a sensor assembly affixable to a drill string in a drilling unit and a sensor for detecting vibrations in the drill string. A first processor is in signal communication with the sensor and is programmed to digitally sample signals from the sensor. A transmitter in signal communication with the first processor communicates the digitized signals to a device disposed apart from the drill string. The first processor is programmed to operate the signal. An electric power source to provides power to the sensor, the first processor and transmitter. Either or both the first processor and a second processor associated with the device is programmed to calculate properties of rock formations using only detected vibration signals from the drill string.

Abstract: A method for determining properties of rock formations using drill string vibration measurements includes entering into a processor signals corresponding to vibrations detected along a rotating part of a drill string while drilling a borehole. The vibration signals are transformed into transformed signals representing elastic response of the drill string, the rock formations and borehole fluid to a filtered impulse originating at a known location along the drill string. Properties of the rock formations are calculated using the transformed signals.