Abstract: Provided herein, at least in part, are methods of treating a hematologic malignancy in a human subject in need thereof, comprising orally administering to the subject duvelisib or a pharmaceutically acceptable form thereof.

Abstract: Disclosed is a refiner filling piece for a refiner having a rotor that rotates about an axis of rotation and cooperates with a stator to mechanically treat a pulp containing cellulosic fibers. The refiner filling piece is mountable to the rotor or the stator. The refiner filling piece comprises a base and a plurality of spaced-apart refiner bars, each refiner bar having a leading surface and a trailing surface. At least one of the refiner bars has a leading surface coated with a first coating and a trailing surface coating with a second coating. The first and second coatings have different chemical compositions and/or different physical properties. Alternatively, the first and second coatings may be applied to distinct portions of the same surface.

Abstract: Provided herein, at least in part, are methods of treating a hematologic malignancy in a human subject in need thereof, comprising orally administering to the subject duvelisib or a pharmaceutically acceptable form thereof.

Abstract: The present invention relates to methods for treating abnormal cell growth (e.g., cancer) in a subject identified as having a KRAS mutation (e.g., KRAS G12X mutation (e.g., KRAS G12V, KRAS G12D, KRAS G12A, KRAS G12R, KRAS G12S, or KRAS G12C)) comprising administering to the subject an effective amount of a MEK inhibitor (e.g., a dual RAF/MEK inhibitor) alone or in combination with an additional agent.

Abstract: Prediction methods including statistical and artificial intelligence methods to predict the prescribing behavior and characteristics and size of patient populations under the care of health care providers from limited data, based on processes developed on integrated medical and pharmaceutical claims data. Prescribers can be classified into groups and subgroups, and marketing recommendations can be made to organizations with interest in the drug prescriptions based on prescription data; sales force effectiveness and marketing message effectiveness products can also be developed.