Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods that utilize a phenomap and germline data to generate a measure of target discovery power and gene targets for trait of interest. Indeed, the disclosed systems can sample a test subset of genomic patient data samples from a combined set of data corresponding to a trait of interest. For instance, the disclosed systems identify a test gene target from the sampled test subset that satisfies a threshold correlation with the trait of interest. In some instances, the disclosed systems generate a test phenomap gene target by comparing a test gene target in the digital phenomap with additional genes in the digital phenomap. Moreover, the disclosed systems can generate a measure of target discovery power of the digital phenomap by comparing the test phenomap gene target with a gene target set identified from the combined set.