Abstract: Various methods, apparatuses/systems, and media for implementing a standalone application module are disclosed. A configuration database stores information about one or more infrastructure resources. A receiver receives a request to connect to an infrastructure resource. A processor accesses the configuration database to fetch information about the infrastructure resource; accesses one or more external resource databases to fetch infrastructure resources that are required to run an application; dynamically creates the infrastructure resources accessed from the one or more external resource databases: and establishes and maintains a connection to the dynamically created infrastructure resources required by the application to function running in background in a user's system.

Abstract: A method of making a structural member from hemp stalks includes feeding a plurality of the hemp stalks into a baler that bundles and aligns the hemp stalks in a common axial direction. A hemp cord is used to bound the hemp stalks into a continuous hemp extrusion, which is then cut into a plurality of hemp logs that are then saturated with an adhesive mixture by an adhesive sprayer that coats each side of the hemp log, or a dip tank. Each hemp log is then introduced into a mold and compressed by 60%-80% to form an interlocking hemp board, a plurality of which are combined to form the structural member after drying by applying the adhesive mixture and then compressing the plurality of interlocking hemp boards in a press until cured. Such a structural member may then be further cut into a finished product, such as two-by-fours.

Abstract: There is a daily dosage for treating pulmonary arterial hypertension (PAH) of two discrete dosage forms each having up to 600 mg of rodatristat ethyl or up to 1200 mg of rodatristat ethyl once per day. There are methods for treating PAH in human patients in need thereof via administration of the dosage forms. There is also a method for treating PAH via daily administration of an amount of a first compound of rodatristat ethyl and an amount of a second compound selected from among ambrisentan, sildenafil, tadalafil, bosentan, treprostinil, selexipag, macitentan, and a combination of two or more thereof. The combination results in an additive or synergistic reduction in symptoms or side effects of PAH compared to the two alone with a low risk for drug-drug interaction, such with a Cmax, unbound in the bloodstream of less than 0.028 ?M. The combination can also result in neither rodatristat ethyl nor its active metabolite rodatristat substantially impacting metabolism of the second compound in the bloodstream.

Abstract: Disclosed in some examples are systems, methods, and machine-readable media for improved data categorization for group organization. To improve participation, a user may be associated with a group. Anonymized health data from the users may be aggregated to generate one or more target goals, which may be selected by the group as a target goal. A number of groups may compete against other groups, where the competition may be scored based on progress toward their respective selected goals. The generation of target goals and the group progress toward each selected goal may be based on improvement or maximization of user participation.

Abstract: There is a crystalline compound of (S)-ethyl 8-(2-amino-6-((R)-1-(5-chloro-[1,1?-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate that exhibits an XRPD pattern having a characteristic peak at 19.05±0.20 (° 2?). There is also a pharmaceutical composition containing the compound. There is also a dosage form containing the crystalline compound and one or more pharmaceutically acceptable excipients. There is also a method for crystallizing/recrystallizing the compound. There is also a method for treating or preventing a disease with the compound.

Abstract: There is a crystalline compound of (S)-ethyl 8-(2-amino-6-((R)-1-(5-chloro-[1,1?-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate that exhibits an XRPD pattern having a characteristic peak at 19.05±0.20 (° 2?). There is also a pharmaceutical composition containing the compound. There is also a dosage form containing the crystalline compound and one or more pharmaceutically acceptable excipients. There is also a method for crystallizing/recrystallizing the compound. There is also a method for treating or preventing a disease with the compound.

Abstract: Various methods, apparatuses/systems, and media for implementing a standalone application module are disclosed. A configuration database stores information about one or more infrastructure resources. A receiver receives a request to connect to an infrastructure resource. A processor accesses the configuration database to fetch information about the infrastructure resource; accesses one or more external resource databases to fetch infrastructure resources that are required to run an application; dynamically creates the infrastructure resources accessed from the one or more external resource databases; and establishes and maintains a connection to the dynamically created infrastructure resources required by the application to function running in background in a user's system.

Abstract: Disclosed in some examples are systems, methods, and machine-readable media for improved information systems. These improved information systems provide a technical solution that includes a predictive learning system and improved data analysis. The data analysis processes multiple data input streams simultaneously, and applies digital signal processing to identify correlation between or among multiple data input streams. The user interface is used to present outputs according to personalized data profile characteristics. In some examples, the user interface includes multiple information cards that are formatted and prioritized based on relevance or urgency.

Abstract: There is a crystalline compound of (S)-ethyl 8-(2-amino-6-((R)-1-(5-chloro-[1,1?-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate that exhibits an XRPD pattern having a characteristic peak at 19.05±0.20 (° 2?). There is also a pharmaceutical composition containing the compound. There is also a dosage form containing the crystalline compound and one or more pharmaceutically acceptable excipients. There is also a method for crystallizing/recrystallizing the compound. There is also a method for treating or preventing a disease with the compound.

Abstract: A microfluidic system includes a microfluidic device connected to a bubble trap device whereby fluid flowing to the microfluidic device passes through the bubble trap device to remove gas bubbles prior to entering the microfluidic device. The bubble trap can include a separation chamber and an exhaust chamber separated by a hydrophobic porous membrane and gas bubbles in the fluid entering the separation chamber pass through the hydrophobic porous membrane into the exhaust chamber while the fluid remains in the separation chamber. The bubble trap can be formed by bonding a first body portion to a first side of the hydrophobic porous membrane and bonding a second body portion to a second side of the hydrophobic porous membrane. The exhaust chamber can be connected to an elongated exhaust channel that limits the evaporation losses of the fluid through the hydrophobic porous membrane.

Abstract: A completion tool for gravel pack and frac pack operations for installing a sump packer and perforating a casing in one trip of a work string. The completion tool is disposed on the end of a work string and includes a perforating gun and a packer attached to the distal end of the completion tool by a coupling. The coupling is such that once the packer is set, the rest of the completion tool can be detached from the packer. After detachment, the completion tool can be repositioned to fire the perforating gun. Positioning of the packer and perforating gun may be accomplished by correlating off of other equipment or by use of logging-while-drilling or measurement-while-drilling equipment incorporated into the completion tool.

Abstract: A microfluidic system includes a microfluidic device connected to a bubble trap device whereby fluid flowing to the microfluidic device passes through the bubble trap device to remove gas bubbles prior to entering the microfluidic device. The bubble trap can include a separation chamber and an exhaust chamber separated by a hydrophobic porous membrane and gas bubbles in the fluid entering the separation chamber pass through the hydrophobic porous membrane into the exhaust chamber while the fluid remains in the separation chamber. The bubble trap can be formed by bonding a first body portion to a first side of the hydrophobic porous membrane and bonding a second body portion to a second side of the hydrophobic porous membrane. The exhaust chamber can be connected to an elongated exhaust channel that limits the evaporation losses of the fluid through the hydrophobic porous membrane.

Abstract: The present invention includes anhydrous crystalline forms of (2S,4S)-4-fluoro-1-[4-fluoro-?-(4-fluorophenyl)-L-phenylalanyl]-2-pyrrolidinecarbonitrile p-toluenesulfonic acid salt.

Abstract: A downhole tool assembly including a sealing device and a sensing device for sensing parameters associated with the operation of the sealing device.

Abstract: The present invention provides processes and compounds that are useful in the preparation of (3?,3a?,6ahexahydrofuro[2,3-b]furan-3-ol and diastereoisomers thereof, which are useful in the preparation of compounds that may be inhibitors of HIV aspartyl protease.

Abstract: A packer and actuator therefor configured for use in relatively high hydrostatic pressure environments. In a described embodiment, a packer for use in a subterranean well includes an actuator for setting the packer. The actuator includes multiple pistons circumferentially spaced apart from each other.

Abstract: A packer includes one dual, or double acting, slip and a single acting slip positioned on a mandrel on opposite sides of a packing element and a setting cylinder. The single acting slip is designed to resist forces acting on the mandrel in one direction. Setting forces generated by the setting cylinder are coupled to the mandrel through a releasing sleeve. When the releasing sleeve is decoupled from the mandrel, the slip setting forces on both slips and the packing element are released and the packer can be retrieved from a well. In a preferred form, the releasing sleeve may be decoupled from the mandrel by multiple means.

Abstract: Methods of releasing a well tool set in a wellbore are provided. In various embodiments, a well tool, such as a packer, is released from sealing and gripping engagement within a wellbore using alternate methods. A dual-string packer is described in which the packer may be released by severing a mandrel of the packer, displacing a piston of the packer, or by displacing a retaining device in a flow passage of the packer.