Abstract: A lightguide formed from a single substrate includes a substrate and a plurality of reflective structures disposed on the substrate. These reflective structures form one or more incouplers, exit pupil expanders, and outcouplers of the lightguide and are each configured to reflect light representative of an image. The lightguide also includes an effectively transparent overmold material disposed over the reflective structures that, together with at least a portion of the substrate, forms a first surface of the substrate. Further, the lightguide includes a second surface formed by removing at least a portion of the substrate via a material removal operation.

Abstract: The application provides devices, kits and methods for a streamlined lateral flow assay for sample preparation, optional amplification, and detection of a target nucleic acid using programmable nuclease reagents.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: Various techniques pertaining to methods, systems, and computer program products a spatial persistence process that places a virtual object relative to a physical object for an extended-reality display device based at least in part upon a persistent coordinate frame (PCF). A determination is made to decide whether a drift is detected for the virtual object relative to the physical object. upon or after detection of the drift or deviation, the drift or deviation is corrected at least by updating a tracking map into an updated tracking map and further at least by updating the persistent coordinate frame (PCF) based at least in part upon the updated tracking map, wherein the persistent coordinate frame (PCF) comprises six degrees of freedom relative to the map coordinate system.

Abstract: A lignocellulosic mixture comprising: (a) a binder composition comprising: (i) an isocyanate compound; (ii) a sulfonic acid compound; and optionally, (iii) a catalyst compound, (iv) an acidifying compound different from Component (ii), and (v) other additive compounds; and (b) one or more lignocellulosic particles wherein at least a portion of the lignocellulosic particles is partially coated with the binder composition wherein the ADHESIVE MEMORY LOSS of the binder composition is less than or equal to 50 and the METAL LOSS on a surface of a metallic article that comes into contact with the binder composition is greater than or equal to ?0.00009.

Abstract: The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: A waveguide includes an outcoupler with a dual reflective facet configuration. The dual reflective facet configuration includes a first set of reflective facets to receive light from a first direction and reflect the light incident thereon to an outcoupling direction. The dual reflective facet configuration also includes a second set of reflective facets to receive light from a second direction and reflect the light incident thereon to the outcoupling direction.

Abstract: A device, includes a first user input and a digital switch coupled to the first user input, wherein the digital switch in operation generates a first signal in response to a first user interaction with the first user input. The device also includes a second user input and an analog position encoder switch coupled to the second user input, wherein the digital switch in operation generates a second signal in response to a second user interaction with the second user input. The device also includes a touch input disposed on a rear face of the device, wherein the touch input is selectively programmable to correspond to one of the first user input or the second user input.

Abstract: The present disclosure generally relates to video gaming systems, which utilize a video game controller in electronic communication with a computing device. One embodiment includes a video gaming system, including a pair of video game controller input modules non-removably secured to a rigid, fixed length bridge section, a smart device holder attached to the rigid, fixed length bridge section, and a smart device secured by the smart device holder such that an entire back surface of the smart device lies fixed in a plane, wherein said plane is parallel to a front surface of the rigid, non-expandable bridge section.

Abstract: The present disclosure generally relates to video gaming systems, which utilize a video game controller in electronic communication with a computing device. One embodiment includes a video gaming system, including a pair of video game controller input modules non-removably secured to a rigid, fixed length bridge section, a smart device holder attached to the rigid, fixed length bridge section, and a smart device secured by the smart device holder such that an entire back surface of the smart device lies fixed in a plane, wherein said plane is parallel to a front surface of the rigid, non-expandable bridge section.

Abstract: The present disclosure generally relates to video gaming systems, which utilize a video game controller in electronic communication with a computing device. One embodiment includes a video gaming system, including a pair of video game controller input modules non-removably secured to a rigid, fixed length bridge section, a smart device holder attached to the rigid, fixed length bridge section, and a smart device secured by the smart device holder such that an entire back surface of the smart device lies fixed in a plane, wherein said plane is parallel to a front surface of the rigid, non-expandable bridge section.

Abstract: Control systems for liquid lenses can use feedback control using one or more measured parameters indicative of a position of the fluid interface in the liquid lens. Capacitance between a fluid and an electrode in the liquid lens can vary depending on the position of the fluid interface. Current mirrors can be used for making measurements indicative of the capacitance and/or the fluid interface position. The liquid lens can be calibrated using the measurements indicative of capacitance and/or fluid interface position as the voltage is driven across an operational range. A control system can use pulse width modulation (PWM) for driving a liquid lens, and a carrier frequency for the PWM signals can be varied to control power consumption in the liquid lens. The slew rate can be adjustable to control power consumption in the liquid lens.

Abstract: An assembly includes a busbar of a traction battery pack, and at least one terminal of a battery cell of the traction battery pack. The at least one terminal is electrically coupled to the busbar. The assembly further includes a thermal exchange plate, and a thermal interface material that communicates thermal energy to the thermal exchange plate from the at least one terminal, from the busbar, or both.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: Methods for managing non-player characters and power centers in a computer game are based on character hierarchies and individualized correspondences between each character's traits or rank and events that involve other non-player characters or objects. Players may share power centers, character hierarchies, non-player characters, and related quests involving the shared objects with other players playing separate and unrelated game instances over a computer network, with the outcome of the quests reflected in different the games. Various configurations of game machines are used to implement the methods.

Abstract: A flow path assembly for a gas turbine engine is provided. The flow path assembly may include an outer casing comprising a metal material having a first coefficient of thermal expansion, a ceramic structure comprising a ceramic material having a second coefficient of thermal expansion, and a mounting component attached on a first end to the outer casing and attached on a second end to the ceramic structure. The mounting component may be constructed from at least two materials transitioning from the first end to the second end such that the coefficient of thermal expansion is different at the first end than the second end.

Abstract: The invention herein provides devices, e.g., non-electronic, non-heating, or both non-electronic and non-heating, devices for delivering volatile compound(s) to the mouth. In aspects devices comprise first and second components releasably held together by a selectively releasable attachment mechanism, such that the first and second components can be completely disengaged from one another. In aspects, devices further comprise an adjustable airflow control mechanism controlled by the rotation of the first and second components relative to one another. In aspects, rotation of the first and second components provides an audible, tactile, or audible and tactile indication of movement indicating a change in airflow control setting(s). Devices can further comprise one or more visual indicators indicating spatial orientation of one or more device components, the status of the airflow control setting(s), or both.

Abstract: A wearable cooling device that is designed to rapidly restore and/or maintain a user's thermal comfort is provided. The disclosed wearable cooling device is versatile and may be affixed to or in contact with (or close proximity to) a variety of locations on a user's body, e.g., wrist, neck and ankle, among others. The wearable cooling device utilizes a forced air device, e.g., a fan, that blows air onto a wetted piece of media, e.g., fabric, which is in direct contact with a high thermally conductive element, e.g., copper or aluminum. The high thermally conductive element may be in contact with a user's skin or with a user's outer clothing. The wetted media is situated between the forced air device and the high thermally conductive element. When the forced air device is activated, the exhaust air passes onto and around the wetted media, which in turn cools the high thermally conductive element. As a result, the high thermally conductive element cools down the user.

Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.

Abstract: A historical horse racing (HHR) gaming system and method are provided that facilitate gameplay on one or a plurality of gameplay stations connected to a gaming server. The gaming server is configured to identify, upon receiving a gameplay request, a first plurality of events to execute. The gaming server is configured to receive a wager from a player and to compare the wager against a scorecard for the plurality of events, with a payout determined from the correct and incorrect predictions. The first plurality of events is determined in a time-dependent manner so as to approximate the gameplay experience of live and/or in-person gaming experiences.