Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.

Abstract: A fault sensing circuit is provided in a remote device configured to be connected to an end of line resistor (EOLR) that is used to detect wiring faults. The fault sensing circuit includes a current monitoring subcircuit configured to detect when an input current of the remote device has crossed a fault threshold corresponding to a fault in the remote device. The fault sensing circuit further includes a switching subcircuit connected to the current monitoring subcircuit and the EOLR. The switching subcircuit is configured to electrically connect a fault resistor in parallel with the EOLR to change a value of an end of line resistance for a fault indication when the input current of the remote devices has crossed the fault threshold.

Abstract: A fault sensing circuit is provided in a remote device configured to be connected to an end of line resistor (EOLR) that is used to detect wiring faults. The fault sensing circuit includes a current monitoring subcircuit configured to detect when an input current of the remote device has crossed a fault threshold corresponding to a fault in the remote device. The fault sensing circuit further includes a switching subcircuit connected to the current monitoring subcircuit and the EOLR. The switching subcircuit is configured to electrically connect a fault resistor in parallel with the EOLR to change a value of an end of line resistance for a fault indication when the input current of the remote devices has crossed the fault threshold.

Abstract: A method of using a processing computer comprising a memory comprising a hash index table and an array index table is disclosed. The method includes receiving an initial request message comprising a plurality of data fields with data elements for a transaction, and creating service request messages, where each service request message comprises a transaction key and data elements. The method includes transmitting the service request messages to server computers, which process them and generate service response messages, each service response message having the transaction key and response data. The method includes receiving the service response messages. The method includes for each of the service response messages: accessing the hash index table and determining a row address identifier for a row in the array index table based on the transaction key, and accessing data in the row of the array index table associated with the row address identifier.

Abstract: An at least partially floorless semirigid poultry enclosure configured to flex and/or adjust to accommodate undulating terrain during movement across a field. The semirigid poultry enclosure may comprise a semirigid foundation. The semirigid foundation may include one or more flexible portions disposed between two or more rigid structural elements. The semirigid poultry enclosure may include an automated movement system configured to facilitate movement of the semirigid poultry enclosure on a field. The automated movement system may be configured to move a semirigid poultry enclosure that is at least 90 feet in length via multiple drive units coupled to a semirigid foundation.

Abstract: A pivot motor for a hair clipper is provided, including a stator with a plurality of laminations, a bobbin located in operational relation to the stator and having a coil of wire wound around the bobbin, an armature being configured for driving a hair clipper moving blade at one end, and having at least one magnet at an opposite end, the armature having a pivot point, and the motor being configured for operation between 2.5 and 4.2 Volts.

Abstract: A method of fabricating a lens element for an adjustable power lens of the kind comprising two lens elements that are slidable relative to one other in a direction transverse the optical axis of the lens and have respective lens surfaces that are shaped to act together to form a corrective lens, the power of which varies according to the relative disposition of the two lens elements, the method comprising the steps of forming a lens puck having two opposite faces, which are shaped to form opposite lens surfaces of one of the lens elements of the adjustable power lens, the puck having at least one alignment feature, and thereafter edging the puck to a desired eye shape with reference to the alignment feature.

Abstract: An electrical connection system for a traction battery pack includes a first battery array, a second battery array, and a plug-and-socket coupler that electrically connects the first battery array to the second battery array when in an engaged position. A method of electrically connecting battery arrays of a traction battery includes electrically connecting a first battery array to a second battery array by moving the first battery array relative to the second battery array.

Abstract: Vascular filters and deflectors and methods for filtering bodily fluids. A blood filtering assembly can capture embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature. A blood deflecting assembly can deflect embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature.

Abstract: A set of material candidates expected to yield materials with target properties can be generated. A subject matter expert's decision indicating accepted and rejected material candidates from the set of material candidates can be received. Based on the subject matter expert's input, a machine learning model can be trained to replicate the subject matter expert's decision.

Abstract: Provided are devices for delivering volatile compound(s) to individuals. The delivery devices can be unpowered devices. The volatile compound(s) can be flavored. Delivery device can comprise engageable components releasably held together by a selectively releasable attachment mechanism. In aspects, the delivery devices further comprise an adjustable airflow control mechanism. In aspects, movement of delivery device components is associated with visual, audible, tactile, or audible and tactile indication of movement or position of device elements. In aspects, element(s) of a delivery device or a device in a system serve as a fidget movement element, being detectably moveable within a short period upon application of a small initiation force easily being returned to a position suitable for repeating the movement. Further provided are methods of using such delivery devices or systems for promoting user sensory experiences or for other beneficial effects, such as reducing habit-related behaviors or sensations.

Abstract: Systems and techniques for wireless implantable devices, for example implantable biomedical devices employed for biomodulation. Some embodiments include a biomodulation system including a non-implantable assembly including a source for wireless power transfer and a data communications system, an implantable assembly including a power management module configured to continuously generate one or more operating voltage for the implantable assembly using wireless power transfer from the non-implantable assembly, a control module operably connected to at least one communication channel and at least one stimulation output, the control module including a processor unit to process information sensed via the at least one communication channel and, upon determining a condition exists, to generate an output to trigger the generation of a stimulus.

Abstract: A method of operating a cleaning and transferring system in a venue with a first location and a second location includes receiving one or more accessories onto a conveyor at the second location. The method also includes transferring the one or more accessories from the second location to the first location via the conveyor. The method further includes cleaning the one or more accessories during the transferring of the one or more accessories from the second location to the first location via the conveyor. The method further includes receiving one or more guest items onto the conveyor at the first location. The method further includes transferring the one or more guest items from the first location to the second via the conveyor.

Abstract: The present disclosure provides various systems, diagnostic devices, and methods for nucleic acid analysis. The systems, devices, and methods allow for the analysis of nucleic acids, in a sample, via programmable nuclease-based assays. Provided are systems comprising an instrument and a cartridge allowing for point of care use. The systems, devices, and methods described herein can be configured for multiplexed detection of nucleic acids in a single sample.

Abstract: Embodiments of the disclosure provide application management capabilities to enterprises. A computing device of a user, associated with the enterprise, receives an enrollment token signed with a certificate. The enrollment token includes an enterprise identifier associated with the enterprise. The computing device receives a package containing one or more applications. The package also includes an enterprise identifier. Installation and execution of one or more applications from the received package is accepted or rejected based on a comparison of the enterprise identifier from the enrollment token with the enterprise identifier from the received package or application. A web service provides validation services by monitoring the installation and execution of applications on the computing devices associated with the enterprise.

Abstract: A cleaning-disinfecting system may be utilized for one or both of cleaning and/or disinfecting medical devices. The cleaning-disinfecting system may be a portable battery-powered medical device washer-disinfector. The systems, devices, or methods may be specifically designed for use at home or other contexts and can wash and disinfect single or multiple medical devices simultaneously. The cleaning-disinfecting system may automatically reprocess medical devices placed within the cleaning-disinfecting system. The cleaning-disinfecting system may store medical devices after reprocessing without exposing the medical devices to potential contamination from the environment.