Abstract: A soluble, heterodimeric interleukin 18 (IL-18) receptor molecule is described which comprises two subunits, one of which comprises an extracelluar domain, or a fragment thereof, of IL-18R, and the other of which comprises an extracelluar domain, or a fragment thereof, of AcPL. Preferably, the soluble, heterodimeric receptor binds to IL-18 with higher affinity than does either IL-18R or AcPL alone.

Abstract: A bispecific monoclonal antibody is described which comprises two moieties, one of which comprises an antigen-binding region which is specific for either the IL-12R&bgr;1 or the IL-12R&bgr;2 subunit of an IL-12 receptor, and the other of which comprises an antigen-binding region which is specific for either the IL-18R or the AcPL subunit of an IL-18 receptor.

Abstract: Compounds of formula I ##STR1## are useful for treating TNF-mediated diseases.

Abstract: A pharmaceutically composition for treating MS comprising an effective amount of a combination of a PDE IV inhibitor and an anti-inflammatory and immunomodulatory drug in a pharmaceutically acceptable carrier.

Abstract: A device and method is provided for sensing an object or vehicle in proximity to a sensing zone, wherein the device is exposed to an environment temperature. The object sensing device comprises a sensor, such as an inductive loop having a characteristic, such as the inductance of the inductive loop, responsive to the proximity of the object is to the sensor; a signal generator, such as an oscillator, coupled to the sensor for producing a first periodical signal cycling at a first frequency dependent on the sensor characteristic and the environment temperature.