Patents by Inventor Daniel Philibert
Daniel Philibert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4865767Abstract: Novel radioactive steroids labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms useful for revealing receptors of glucocorticoids and in determining the number of fixation sites of glucocorticoids and novel intermediates.Type: GrantFiled: December 19, 1985Date of Patent: September 12, 1989Assignee: Roussel UclafInventors: Alain Jouquey, Daniel Philibert, Martine Moguilewsky, Jean-Noel Veltz
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Patent number: 4778506Abstract: A method and apparatus for the transfer of pane objects such as glass comprises a conveyor along which the pane is accelerated past the downstream end of the conveyor. As the pane leaves the conveyor, it is received by a device which is aligned substantially parallel to the trajectory of the path of the pane. The device receives the pane, and transfers it to the next work station.Type: GrantFiled: April 24, 1987Date of Patent: October 18, 1988Assignee: Saint-Gobain VitrageInventors: Jean-Marc Petitcollin, Daniel Philibert
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Patent number: 4778508Abstract: A device and process for transferring glass panes for bending comprise the raising of glass panes with a gaseous flow until they meet with an upper conveyor, maintaining contact with that conveyor and simultaneously shifting them along that conveyor, then bringing them down anew on a bending form upon which they subside.Type: GrantFiled: April 24, 1987Date of Patent: October 18, 1988Assignee: Saint-Gobain VitrageInventors: Jean-Marc Petitcollin, Pierre Marchal, Bernard Letemps, Daniel Philibert
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Patent number: 4753932Abstract: A novel steroid of the formula ##STR1## wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or --S-- and R is optionally substituted carbocyclic aryl or heterocyclic aryl, R.sub.2 is methyl or ethyl, R.sub.3 is selected from the group consisting of optionally substituted alkyl of 1 to 8 carbon atoms and optionally substituted alkenyl and alkynyl of 2 to 8 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and acyl, ##STR2## is selected from the group consisting of ##STR3## R.sub.6 is selected from the group consisting of hydrogen and methyl, the wavy line indicates .alpha. or .beta.- and the dotted line in 1(2) indicates the optional presence of a second carbon-carbon bond and novel process and intermediates therefore having anti-glucocorticoid activity.Type: GrantFiled: January 14, 1986Date of Patent: June 28, 1988Assignee: Roussel UclafInventors: Jean-Georges Teutsch, Germain Costerousse, Vesperto Torelli, Daniel Philibert
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Patent number: 4664850Abstract: Novel radioactive steriods labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms useful for revealing receptors of glucocorticoids and in determining the number of fixation sites on glucocorticoids and novel intermediates.Type: GrantFiled: June 14, 1984Date of Patent: May 12, 1987Assignee: Roussel UclafInventors: Alain Jouquey, Daniel Philibert, Martine Moguilewsky, Jean-Noel Veltz
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Patent number: 4634696Abstract: Novel 19-nor-steroids of the formula ##STR1## wherein R.sub.1 is an organic group of 1 to 18 carbon atoms optionally containing at least one heteroatom with the atom immediately adjacent the 11-carbon atom being carbon, R.sub.2 is a hydrocarbon of 1 to 8 carbon atoms, X is the remainder of a pentagonal or hexagonal ring optionally substituted and optionally containing one unsaturated--bond, the A and B rings are selected from the group consisting of ##STR2## R' and R" are individually selected from the group consisting of hydrogen, --CN and alkyl of 1 to 4 carbon atoms with at least one being other than hydrogen, R.sub.x is selected from the group consisting of hydrogen and OR.sub.e, R.sub.e is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and acyl, R.sub.a may be in the E or Z positions as indicated by the wavy line and is selected from the group consisting of ##STR3## and acyloxy, R.sub.a ' and R.sub.Type: GrantFiled: July 30, 1985Date of Patent: January 6, 1987Assignee: Roussel UclafInventors: Jean-Georges Teutsch, Vesperto Torelli, Roger Deraedt, Daniel Philibert
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Patent number: 4634695Abstract: Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R.sub.1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the atom immediately adjacent to the 11-carbon atom being carbon, R.sub.2 is a hydrocarbon of 1 to 8 carbon atoms, X is selected from the group consisting of a pentagonal ring and a hexagonal ring optionally substituted and optionally containing a double bond, B and C together form a double bond or an epoxy group, the C.dbd.A group at position 3 is selected from the group consisting of C.dbd.O, ketal, which may be open or closed ##STR2## are selected from the group consisting of alkyl of 1 to 8 carbon atoms and aralkyl of 7 to 15 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having anti-glucocorticoid activity and a process for their preparation.Type: GrantFiled: January 22, 1985Date of Patent: January 6, 1987Assignee: Roussel UclafInventors: Vesperto Torelli, Jean G. Teutsch, Daniel Philibert
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Patent number: 4547493Abstract: Novel 19-nor-steroids of the formula ##STR1## wherein R.sub.1 is an organic group of 1 to 18 carbon atoms optionally containing at least one heteroatom with the atom immediately adjacent the 11-carbon atom being carbon, R.sub.2 is a hydrocarbon of 1 to 8 carbon atoms, X is the remainder of a pentagonal or hexagonal ring optionally substituted and optionally containing one unsaturated bond, the A and B rings are selected from the group consisting of ##STR2## R' and R" are individually selected from the group consisting of hydrogen, --CN and alkyl of 1 to 4 carbon atoms with at least one being other than hydrogen, R.sub.x is selected from the group consisting of hydrogen and OR.sub.e R.sub.e is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and acyl, R.sub.a may be in the E or Z positions as indicated by the wavy line and is selected from the group consisting of ##STR3## and acyloxy, R.sub.a ' and R.sub.Type: GrantFiled: June 6, 1983Date of Patent: October 15, 1985Assignee: Roussel UclafInventors: Jean-Georges Teutsch, Vesperto Torelli, Roger Deraedt, Daniel Philibert
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Patent number: 4540686Abstract: Novel 3-keto-19-nor-.DELTA..sup.4,9 -steroids of the formula ##STR1## possessing a remarkable antiglucocorticoidal activity.Type: GrantFiled: June 8, 1984Date of Patent: September 10, 1985Assignee: Roussel UclafInventors: Daniel Philibert, Jean G. Teutsch, Germain Costerousse, Roger Deraedt
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Patent number: 4519946Abstract: Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R.sub.1 is an organic radical of 1 to 18 carbons atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the atom immediately adjacent to the 11-carbon atom being carbon, R.sub.2 is a hydrocarbon of 1 to 8 carbon atoms, X is selected from the group consisting of a pentagonal ring and a hexagonal ring optionally substituted and optionally containing a double bond, B and C together form a double bond or an epoxy group, the C=A group at position 3 is selected from the group consisting of C-O, ketal, which may be open or closed ##STR2## --C.dbd.NOH,--C--NOAlK.sub.3 and C--CH.sub.2,AlK.sub.1, AlK.sub.2 and AlK.sub.3 are selected from the group consisting of alkyl of 1 to 8 carbon atoms and aralkyl of 7 to 15 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having anti-glucocoritcoid activity and a process for their preparation.Type: GrantFiled: May 25, 1984Date of Patent: May 28, 1985Assignee: Roussel UclafInventors: Jean G. Teutsch, Germain Costerousse, Daniel Philibert, Roger Deraedt
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Patent number: 4477445Abstract: Novel 3-keto-19-nor-.DELTA.Type: GrantFiled: February 23, 1983Date of Patent: October 16, 1984Assignee: Roussel UclafInventors: Daniel Philibert, Jean G. Teutsch, Germain Costerousse, Roger Deraedt
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Patent number: 4447424Abstract: Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R.sub.1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the atom immediately adjacent to the 11-carbon atom being carbon, R.sub.2 is a hydrocarbon of 1 to 8 carbon atoms, X is selected from the group consisting of a pentagonal ring and a hexagonal ring optionally substituted and optionally containing a double bond, B and C together form a double bond or an epoxy group, the C.dbd.A group at position 3 is selected from the group consisting of C--O, ketal, which may be open or closed ##STR2## --C.dbd.NOH, --C--NOAlK.sub.3 and C--CH.sub.2, AlK.sub.1, AlK.sub.2 and AlK.sub.3 are selected from the group consisting of alkyl of 1 to 8 carbon atoms and aralkyl of 7 to 15 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having anti-glucocorticoid activity and a process for their preparation.Type: GrantFiled: June 10, 1982Date of Patent: May 8, 1984Assignee: Roussel UclafInventors: Jean G. Teutsch, Germain Costerousse, Daniel Philibert, Roger Deraedt
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Patent number: 4396614Abstract: Novel steroids of the formula ##STR1## wherein R is selected from the group consisting of R.sub.1 and R.sub.2, R.sub.1 is selected from the group consisting of alkyl of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms R.sub.2 is --(CH.sub.2).sub.n --R.sub.3, n is an integer from 1 to 8 and R.sub.3 is selected from the group consisting of free or protected --OH, free or protected --NH.sub.2, monoalkyl and dialkylamino with 1 to 6 carbon atoms, a free, esterified or salified --COOH and halogen X and Y together form ##STR2## or X is OH and Y is --CH.sub.2 --CH.sub.2 --COOM, M is selected from the group consisting of hydrogen, an alkali metal and --NH.sub.4, Ra is selected from the group consisting of hydrogen and methyl, the dotted line in the I(2)-position indicates the optional presence of a double bond and the wavy line indicates that R may be in the .alpha.- or .beta.-position, with the proviso that R is not R.sub.1 or R.sub.2 when n is 1 and R.sub.Type: GrantFiled: December 21, 1981Date of Patent: August 2, 1983Assignee: Roussel UclafInventors: Lucien Nedelec, Vesperto Torelli, Daniel Philibert
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Patent number: 4386085Abstract: Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R.sub.1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the atom immediately adjacent to the 11-carbon atom being carbon, R.sub.2 is a hydrocarbon of 1 to 8 carbon atoms, X is selected from the group consisting of a pentagonal ring and a hexagonal ring optionally substituted and optionally containing a double bond, B and C together form a double bond or an epoxy group, the C.dbd.A group at position 3 is selected from the group consisting of C.dbd.O, ketal, ##STR2## --C.dbd.NOH, --C.dbd.NOAlK.sub.3 and .dbd.CH.sub.2, AlK.sub.1, AlK.sub.2 and AlK.sub.3 are selected from the group consisting of alkyl of 1 to 8 carbon atoms and aralkyl of 7 to 15 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having anti-glucocorticoid activity and a process for their preparation.Type: GrantFiled: January 8, 1982Date of Patent: May 31, 1983Assignee: Roussell UclafInventors: Jean G. Teutsch, Germain Costerousse, Daniel Philibert, Roger Deraedt
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Patent number: 4272530Abstract: Novel 11.beta. -substituted-.DELTA. .sup.1,3,5(10) -estratrienes of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of optionally substituted unsaturated alkyl of 2 to 8 carbon atoms, optionally substituted aryl of 6 to 12 carbon atoms, optionally substituted aralkyl of 7 to 13 carbon atoms and heterocycle with at least one sulfur or oxygen heteroatom, R.sub.2 is alkyl of 1 to 4 carbon atoms, Z is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and aralkyl of 7 to 9 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, hydroxy, acyl of an organic carboxylic acid of 1 to 18 carbon atoms and acyloxy of an organic carboxylic acid of 1 to 18 carbon atoms and R.sub.4 is selected from the group consisting of hydrogen, hydroxy, alkyl and alkoxy of 1 to 8 carbon atoms, acyloxy of an organic carboxylic acid of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms, with the proviso that R.sub.1 is not allyl when Z is hydrogen, R.Type: GrantFiled: January 6, 1978Date of Patent: June 9, 1981Assignee: Roussel UclafInventors: Jean G. Teutsch, Daniel Philibert
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Patent number: 4242335Abstract: Novel 17.alpha.-aryl-steroids of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R.sub.3 is aryl of 6 to 12 carbon atoms optionally substituted with at least one substituent selected from the group consisting of --OH, halogen, alkoxy and alkyl of 1 to 4 carbon atoms and --CF.sub.3, the dotted line in the B ring indicating an optional double bond in the 9(10)-position, and A and B are hydrogen and when there is a double bond in the 9(10)-position, A and B form a double bond in the 11(12) position or B is hydrogen and A is an 11.beta.-hydroxy having progestomimetic activity activity without androgenic activity and a process for their preparation and novel intermediates produced therein.Type: GrantFiled: October 27, 1978Date of Patent: December 30, 1980Assignee: Roussel UclafInventors: Genevieve Azadian, Daniel Philibert, Andre Pierdet
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Patent number: 4233296Abstract: Novel steroids of the formula ##STR1## wherein R.sub.1 is linear or branched alkyl of 1 to 12 carbon atoms, unsaturated alkyl of 2 to 8 carbon atoms optionally substituted, optionally substituted aryl of 6 to 12 carbon atoms, optionally substituted aralkyl of 7 to 13 carbon atoms and a heterocycle with at least one sulfur or oxygen atom, R.sub.2 is alkyl of 1 to 4 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, hydroxy, acyloxy of an organic carboxylic acid of 1 to 18 carbon atoms, alkoxy of 1 to 8 carbon atoms and acyl of an organic carboxylic acid of 1 to 18 carbon atoms and R.sub.4 is selected from the group consisting of hydrogen, hydroxy, alkyl and alkoxy of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms and acyloxy of an organic carboxylic acid of 1 to 18 carbon atoms, with the proviso that R.sub.4 is not hydrogen when R.sub.1 is allyl, R.sub.2 is methyl and R.sub.3 is hydroxy having progestomimetic properties and their preparation.Type: GrantFiled: January 6, 1978Date of Patent: November 11, 1980Assignee: Roussel UclafInventors: Jean G. Teutsch, Daniel Philibert
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Patent number: 4174030Abstract: A device for clearing residues of pulverulent or particulate product from a belt conveyor includes a vibrating roller freely rotatably mounted between an upper carrier run and a lower return run of said conveyor belt and biased into engagement with the inner side of the return run, the vibrating roller being sealed against ingress of dust and other foreign matter and enclosing a vibration generator motor. In such a device the vibration generator motor is protected from the effects of dust and climatic variations and is of compact form. The vibrating roller is resiliently supported by coil springs which thrust the roller against the inside face of the return run of the conveyor belt to ensure that contact is maintained between the vibrating roller and the return run of the conveyor belt even when the conveyor belt is circulating at a high linear speed.Type: GrantFiled: March 29, 1978Date of Patent: November 13, 1979Inventor: Daniel Philibert
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Patent number: 4165326Abstract: Steroids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, tetrahydropyranyl, trityl and trimethylsilyl, R.sub.1 is selected from the group consisting of hydrogen, acryl of an alkanoic acid of 1 to 5 carbon atoms and tetrahyropyranyl and the wavy line indicates that the OR.sub.1 group may be in either position about the carbon atom and a process and intermediates for their preparation which compounds are useful as intermediates to form novel tritium compounds of the formula ##STR2## wherein R and R.sub.1 have the above definition which are useful as intermediates for the production of (6,7-H.sup.3) 17.alpha.,21-dimethyl-19-nor-.DELTA..sup.4,9 -pregnadiene-3,20-dione.Type: GrantFiled: March 30, 1978Date of Patent: August 21, 1979Assignee: Roussel UclafInventors: Roland Bardoneschi, Alain Jouquey, Daniel Philibert
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Patent number: 4154730Abstract: Novel 17-spirosultines of steroids and the corresponding .gamma.-hydroxy acids of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 4 carbon atoms, A is hydrogen and B is hydrogen or hydroxyl of .beta.configuration or A and B together form a double bond, X and Y together form the group ##STR2## or X is --OH and Y is ##STR3## and M is selected from the group consisting of hydrogen, --NH.sub.4 and an alkali metal having a remarkable progestomimetic and antialdosteronic activity and a novel process for their preparation and novel intermediates.Type: GrantFiled: October 20, 1977Date of Patent: May 15, 1979Assignee: Roussel UclafInventors: Vesperto Torelli, Daniel Philibert