Abstract: Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.

Abstract: A method for constructing and executing an XCodes execution plan stored in a self-contained, platform-independent format, the method comprising: providing a plurality of Extensible Markup Language (XML) documents each having content, structure, and a plurality of instruction; identifying a language in which the content of the plurality of XML documents is written; converting the language to a set of abstract, platform-independent instructions (XCodes) representing the structure of the plurality of the XML documents, via a compilation step; converting the set of abstract, platform-independent instructions (XCodes) to a highly optimized, platform-specific form via a loading process; mandating an instruction-space allocation; allowing one or more extension instruction into the XCodes execution plan; setting symbolic references to the one or more extension instructions; ignoring the one or more extension instructions having the symbolic references; and constructing implementation-specific tables.

Abstract: A computer-implemented method of processing an Extensible Markup Language (XML) document can include loading an execution plan into a virtual machine, wherein the execution plan represents an XML schema, and loading an XML document into the virtual machine. XML processing functions available within the virtual machine can be selectively invoked according to the execution plan, wherein the XML processing functions operate upon the XML document. An indication of whether the XML document is valid according to the XML processing functions can be output.

Abstract: The invention relates to regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of the intestine and uro-genital tracts. The invention also relates to recombinant constructs comprising said regulatory sequences, for the control of the targeted expression of determined nucleic acid sequences so-called (heterologous sequences or also transgenes), in cells or tissues originating from the intestinal mucosa. A further object of the invention is to provide cells, tissues or organisms including animals, expressing said determined nucleic acid sequences in a targeted manner.

Abstract: The invention relates to regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of the intestine and uro-genital tracts. The invention also relates to recombinant constructs comprising said regulatory sequences, for the control of the targeted expression of determined nucleic acid sequences so-called (heterologeous sequences or also transgenes), in cells or tissues originating from the intestinal mucosa. A further object of the invention is to provide cells, tissues or organisms including animals, expressing said determined nucleic acid sequences in a targeted manner.